PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31234428-8	2019	Furthermore, SAM enhances the IFN-alpha antiviral activity and protects against hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic hepatitis B virus (HBV) infection.	S-Adenosylmethionine	13-16	interferon alpha 1	Homo sapiens	30-39	
25271158-3	2014	We hypothesized that the GCs enhance IFN signaling by inducing S-adenosylmethionine (AdoMet) when hepatitis B virus (HBV) replication was effectively suppressed by IFN-alpha.	S-Adenosylmethionine	85-91	interferon alpha 1	Homo sapiens	164-173	
25271158-3	2014	We hypothesized that the GCs enhance IFN signaling by inducing S-adenosylmethionine (AdoMet) when hepatitis B virus (HBV) replication was effectively suppressed by IFN-alpha.	S-Adenosylmethionine	63-83	interferon alpha 1	Homo sapiens	164-173	
19857525-5	2010	The potential improvement of S-adenosylmethionine (SAM) in the antiviral effect of IFN-alpha was also investigated.	S-Adenosylmethionine	29-49	interferon alpha 1	Homo sapiens	83-92	
22577887-5	2013	Two therapeutic modalities, betaine and S-adenosylmethionine, can correct methylation defects to attenuate many EtOH-induced liver changes, as well as improve IFN signaling pathways, thereby overcoming viral treatment resistance.	S-Adenosylmethionine	40-60	interferon alpha 1	Homo sapiens	159-162	
21079746-3	2010	S-adenosyl-L-methionine (SAMe) and betaine potentiate IFNalpha signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of IFNalpha on HCV replicons.	S-Adenosylmethionine	0-23	interferon alpha 1	Homo sapiens	54-62	
21079746-3	2010	S-adenosyl-L-methionine (SAMe) and betaine potentiate IFNalpha signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of IFNalpha on HCV replicons.	S-Adenosylmethionine	0-23	interferon alpha 1	Homo sapiens	175-183	
19857525-5	2010	The potential improvement of S-adenosylmethionine (SAM) in the antiviral effect of IFN-alpha was also investigated.	S-Adenosylmethionine	51-54	interferon alpha 1	Homo sapiens	83-92	
16557551-6	2006	We show that treating cells with S-adenosyl-L-methionine (AdoMet) and betaine could restore STAT1 methylation and improve IFNalpha signaling.	S-Adenosylmethionine	33-56	interferon alpha 1	Homo sapiens	122-130	
16557551-6	2006	We show that treating cells with S-adenosyl-L-methionine (AdoMet) and betaine could restore STAT1 methylation and improve IFNalpha signaling.	S-Adenosylmethionine	58-64	interferon alpha 1	Homo sapiens	122-130	
16557551-7	2006	Furthermore, the antiviral effect of IFNalpha in cell culture could be significantly enhanced by the addition of AdoMet and betaine.	S-Adenosylmethionine	113-119	interferon alpha 1	Homo sapiens	37-45