PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10898761-1	2000	Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM).	S-Adenosylmethionine	164-184	methionine adenosyltransferase 1A	Rattus norvegicus	102-107	
10809741-1	2000	We previously reported that S-adenosylmethionine (AdoMet), a key molecule in methylation reactions and polyamine biosynthesis, enhances axenic culture of the AIDS-associated opportunistic fungal pathogen Pneumocystis carinii.	S-Adenosylmethionine	28-48	methionine adenosyltransferase 1A	Rattus norvegicus	50-56	
8920979-2	1996	As a result, S-adenosylmethionine synthetase activity increased 2.3-fold, an effect that was accompanied by increased S-adenosylmethionine, a depletion of ATP and NAD levels, elevation of the S-adenosylmethionine/S-adenosylhomocysteine ratio (the methylation ratio), increased DNA methylation and polyamine levels (spermidine and spermine), and normal GSH levels.	S-Adenosylmethionine	118-138	methionine adenosyltransferase 1A	Rattus norvegicus	13-44	
10580153-1	1999	Protein L-isoaspartyl methyltransferase (Pimt) is a highly conserved enzyme utilising S-adenosylmethionine (AdoMet) to methylate aspartate residues of proteins damaged by age-related isomerisation and deamidation.	S-Adenosylmethionine	86-106	methionine adenosyltransferase 1A	Rattus norvegicus	108-114	
10432295-1	1999	Intracellular deficiency of S-adenosylmethionine (AdoMet) and elevated serum concentrations of tumour necrosis factor alpha (TNF) are hallmarks of toxin-induced liver injury.	S-Adenosylmethionine	28-48	methionine adenosyltransferase 1A	Rattus norvegicus	50-56	
2498524-2	1989	It is reasoned that perturbation of a second regulatory element in polyamine biosynthesis, i.e., the generation of propylamine groups from S-adenosylmethionine (AdoMet), would potentiate the effectiveness of DFMO.	S-Adenosylmethionine	139-159	methionine adenosyltransferase 1A	Rattus norvegicus	161-167	
8810903-1	1996	Glycine N-methyltransferase (GNMT) from rat liver is a tetrameric enzyme with 292 amino acid residues in each identical subunit and catalyzes the S-adenosylmethionine (AdoMet) dependent methylation of glycine to form sarcosine.	S-Adenosylmethionine	146-166	methionine adenosyltransferase 1A	Rattus norvegicus	168-174	
8748929-9	1995	S-adenosylmethionine (AdoMet), the limiting factor in the methylation process, was injected into the lateral ventricle of rats.	S-Adenosylmethionine	0-20	methionine adenosyltransferase 1A	Rattus norvegicus	22-28	
8135750-4	1994	55, 131-138], we proposed that homocysteinaemia arises from an interruption in S-adenosylmethionine"s (AdoMet) coordinate regulation of homocysteine metabolism.	S-Adenosylmethionine	103-109	methionine adenosyltransferase 1A	Rattus norvegicus	79-101	
8280752-2	1994	S-Adenosylmethionine (AdoMet) is an important biologic methylating agent for nucleic acids, phospholipids, biologic amines, and proteins.	S-Adenosylmethionine	0-20	methionine adenosyltransferase 1A	Rattus norvegicus	22-28	
1398482-0	1992	S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury.	S-Adenosylmethionine	0-20	methionine adenosyltransferase 1A	Rattus norvegicus	69-100	
1698095-1	1990	Although the physical and kinetic properties of S-adenosylmethionine (AdoMet) synthetases from different sources are quite different, it appears that these enzymes have structurally or antigenically conserved regions as demonstrated by studies with AdoMet synthetase specific antibodies.	S-Adenosylmethionine	48-68	methionine adenosyltransferase 1A	Rattus norvegicus	70-76	
1698095-1	1990	Although the physical and kinetic properties of S-adenosylmethionine (AdoMet) synthetases from different sources are quite different, it appears that these enzymes have structurally or antigenically conserved regions as demonstrated by studies with AdoMet synthetase specific antibodies.	S-Adenosylmethionine	48-68	methionine adenosyltransferase 1A	Rattus norvegicus	249-255	
3338105-2	1988	Intraperitoneal injection of ethionine to male rats for up to 12 days caused a pronounced fall in S-adenosylmethionine (AdoMet) in liver, but did not or only slightly affect AdoMet in kidney and spleen.	S-Adenosylmethionine	98-118	methionine adenosyltransferase 1A	Rattus norvegicus	120-126	
19111934-1	2009	Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a monomeric enzyme that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the phenolic oxygen of substituted catechols.	S-Adenosylmethionine	146-152	methionine adenosyltransferase 1A	Rattus norvegicus	121-144	
6696933-2	1984	Kinetically, three apparent Km values for S-adenosyl-L-methionine (AdoMet) were obtained when the total [3H]methyl groups incorporation into the phospholipids was examined in the presence of 0.01-250 microM AdoMet.	S-Adenosylmethionine	67-73	methionine adenosyltransferase 1A	Rattus norvegicus	42-65	
3720835-1	1986	The effect of l-isoproterenol on S-adenosyl-L-methionine (Adomet)-mediated phospholipid methylation in rat brain cortex was examined.	S-Adenosylmethionine	58-64	methionine adenosyltransferase 1A	Rattus norvegicus	33-56	
17158459-2	2007	It is abundant in the liver, where it uses excess S-adenosylmethionine (AdoMet) to methylate glycine to N-methylglycine (sarcosine) and produces S-adenosylhomocysteine (AdoHcy), thereby controlling the methylating potential of the cell.	S-Adenosylmethionine	50-70	methionine adenosyltransferase 1A	Rattus norvegicus	72-78	
12163148-1	2002	Hepatic deficiency of S-adenosylmethionine (AdoMet) is a critical acquired metabolic abnormality in alcoholic liver disease (ALD) and in many experimental models of hepatotoxicity.	S-Adenosylmethionine	22-42	methionine adenosyltransferase 1A	Rattus norvegicus	44-50	
15498786-6	2005	These lesions also showed low expression of Mat1A and low activity of methionine adenosyltransferase I/III, whose reaction product, S-adenosyl-l-methionine, enhances IkappaB-alpha expression.	S-Adenosylmethionine	132-155	methionine adenosyltransferase 1A	Rattus norvegicus	70-106	
14967023-1	2004	S-Adenosylmethionine synthetase (MAT) catalyzes formation of S-adenosylmethionine (SAM) from ATP and l-methionine (Met) and hydrolysis of tripolyphosphate to PP(i) and P(i).	S-Adenosylmethionine	61-81	methionine adenosyltransferase 1A	Rattus norvegicus	0-31