PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7086841-1 1982 Structural analogues of decarboxylated S-adenosyl-L-methionine (dc-SAM), product of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase (SAM-DC), with modifications in the side-chain portion of the molecule have been synthesized, and their ability to inhibit SAM-DC has been investigated. S-Adenosylmethionine 39-62 adenosylmethionine decarboxylase 1 Homo sapiens 110-147 3455877-1 1986 Methylglyoxal bis(butylamidinohydrazone) (MGBB) inhibited S-adenosylmethionine decarboxylase (SAMDC) activity competitively with S-adenosylmethionine (SAM) showing the Ki value of 1.8 X 10(-5) M. MGBB showed less SAMDC-stabilizing effect in rat liver in vivo than did methylglyoxal bis-(guanylhydrazone) (MGBG). S-Adenosylmethionine 58-78 adenosylmethionine decarboxylase 1 Homo sapiens 94-99 7086841-1 1982 Structural analogues of decarboxylated S-adenosyl-L-methionine (dc-SAM), product of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase (SAM-DC), with modifications in the side-chain portion of the molecule have been synthesized, and their ability to inhibit SAM-DC has been investigated. S-Adenosylmethionine 39-62 adenosylmethionine decarboxylase 1 Homo sapiens 149-155 7086841-1 1982 Structural analogues of decarboxylated S-adenosyl-L-methionine (dc-SAM), product of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase (SAM-DC), with modifications in the side-chain portion of the molecule have been synthesized, and their ability to inhibit SAM-DC has been investigated. S-Adenosylmethionine 39-62 adenosylmethionine decarboxylase 1 Homo sapiens 271-277 25511700-2 2015 S-adenosylmethionine decarboxylase (AdoMetDc) and spermidine synthase (SpdSyn) are enzymes of this pathway that catalyze successive steps, with the product of the former, decarboxylated S-adenosylmethionine (dcSAM), acting as an aminopropyl donor for the latter enzyme. S-Adenosylmethionine 0-20 adenosylmethionine decarboxylase 1 Homo sapiens 36-44 33040301-9 2021 Inactivation of SAMdc enhances the transformation of S-adenosylmethionine to homocysteine and then to methionine. S-Adenosylmethionine 53-73 adenosylmethionine decarboxylase 1 Homo sapiens 16-21 32218733-4 2020 During the synthesis of spermidine and spermine, an amino-propyl group is provided by decarboxylated S-adenosylmethionine, and the latter is generated from S-adenosylmethionine by AdoMetDC (AdoMet decarboxylase). S-Adenosylmethionine 101-121 adenosylmethionine decarboxylase 1 Homo sapiens 190-210 32218733-4 2020 During the synthesis of spermidine and spermine, an amino-propyl group is provided by decarboxylated S-adenosylmethionine, and the latter is generated from S-adenosylmethionine by AdoMetDC (AdoMet decarboxylase). S-Adenosylmethionine 156-176 adenosylmethionine decarboxylase 1 Homo sapiens 190-210 31971508-7 2020 Finally, we find that G418-induced miscoding alters gene expression with substantial effects on translation of histone genes, selenoprotein genes, and S-adenosylmethionine decarboxylase (AMD1). S-Adenosylmethionine 151-171 adenosylmethionine decarboxylase 1 Homo sapiens 187-191 9225849-1 1997 S-adenosylmethionine decarboxylase (SAMDC; EC 4.1.4.50) is one of the key enzymes in polyamine biosynthesis, and the product of its catalytic reaction, decarboxylated S-adenosylmethionine (dcSAM), serves as an aminopropyl donor in the biosynthesis of spermidine and spermine. S-Adenosylmethionine 0-20 adenosylmethionine decarboxylase 1 Homo sapiens 36-41 19787085-1 2008 S-adenosylmethionine decarboxylase (SAMDC) is an enzyme which converts S-adenosylmethione (SAM), a methyl donor, to decarboxylated SAM (dcSAM), an aminopropyl donor for polyamine biosynthesis. S-Adenosylmethionine 71-89 adenosylmethionine decarboxylase 1 Homo sapiens 0-34 19787085-1 2008 S-adenosylmethionine decarboxylase (SAMDC) is an enzyme which converts S-adenosylmethione (SAM), a methyl donor, to decarboxylated SAM (dcSAM), an aminopropyl donor for polyamine biosynthesis. S-Adenosylmethionine 71-89 adenosylmethionine decarboxylase 1 Homo sapiens 36-41 19787085-1 2008 S-adenosylmethionine decarboxylase (SAMDC) is an enzyme which converts S-adenosylmethione (SAM), a methyl donor, to decarboxylated SAM (dcSAM), an aminopropyl donor for polyamine biosynthesis. S-Adenosylmethionine 36-39 adenosylmethionine decarboxylase 1 Homo sapiens 0-34 16515461-3 2006 AdoMetDC catalyzes decarboxylation of S-adenosylmethionine (AdoMet) which provides aminopropyl groups for spermidine and spermine synthesis. S-Adenosylmethionine 38-58 adenosylmethionine decarboxylase 1 Homo sapiens 0-8 20512387-3 2011 The S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes the irreversible decarboxylation of S-adenosylmethionine (AdoMet), generating the decarboxylated S-adenosylmethionine (dAdoMet), which is a substrate, together with putrescine, for spermidine synthase (SpdS). S-Adenosylmethionine 4-24 adenosylmethionine decarboxylase 1 Homo sapiens 40-48 20512387-3 2011 The S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes the irreversible decarboxylation of S-adenosylmethionine (AdoMet), generating the decarboxylated S-adenosylmethionine (dAdoMet), which is a substrate, together with putrescine, for spermidine synthase (SpdS). S-Adenosylmethionine 40-46 adenosylmethionine decarboxylase 1 Homo sapiens 4-38 20512387-3 2011 The S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes the irreversible decarboxylation of S-adenosylmethionine (AdoMet), generating the decarboxylated S-adenosylmethionine (dAdoMet), which is a substrate, together with putrescine, for spermidine synthase (SpdS). S-Adenosylmethionine 96-116 adenosylmethionine decarboxylase 1 Homo sapiens 4-38 20512387-3 2011 The S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes the irreversible decarboxylation of S-adenosylmethionine (AdoMet), generating the decarboxylated S-adenosylmethionine (dAdoMet), which is a substrate, together with putrescine, for spermidine synthase (SpdS). S-Adenosylmethionine 96-116 adenosylmethionine decarboxylase 1 Homo sapiens 40-48 12674502-1 2003 S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme of the polyamine synthetic pathway providing decarboxylated S-adenosylmethionine for the formation of spermidine and spermine, respectively. S-Adenosylmethionine 122-142 adenosylmethionine decarboxylase 1 Homo sapiens 36-44 7890685-10 1995 Importantly, the protein encoded by the intronless gene was functional, i.e. it catalyzed the decarboxylation of S-adenosylmethionine, and its specific activity was comparable with that of recombinant human AdoMetDC purified according to the same procedure. S-Adenosylmethionine 113-133 adenosylmethionine decarboxylase 1 Homo sapiens 207-215 7752200-9 1995 Thus, the S-adenosylmethionine analogue trans-1S,4S-AdoMao acts as an effective inhibitor of AdoMet-DC and appears to serve as a parasite-specific trypanocidal agent in vitro. S-Adenosylmethionine 10-30 adenosylmethionine decarboxylase 1 Homo sapiens 93-102 7748194-1 1995 The S-adenosylmethionine (AdoMet) analogue AdoMac [S-(5"-deoxy-5"-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopen ten e], an enzyme-activated, irreversible inhibitor of the Escherchia coli form of S-adenosylmethionine decarboxylase (AdoMet-DC), also acts as a potent inhibitor of the human form of the enzyme. S-Adenosylmethionine 4-24 adenosylmethionine decarboxylase 1 Homo sapiens 197-231 7748194-1 1995 The S-adenosylmethionine (AdoMet) analogue AdoMac [S-(5"-deoxy-5"-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopen ten e], an enzyme-activated, irreversible inhibitor of the Escherchia coli form of S-adenosylmethionine decarboxylase (AdoMet-DC), also acts as a potent inhibitor of the human form of the enzyme. S-Adenosylmethionine 4-24 adenosylmethionine decarboxylase 1 Homo sapiens 233-242 7748194-1 1995 The S-adenosylmethionine (AdoMet) analogue AdoMac [S-(5"-deoxy-5"-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopen ten e], an enzyme-activated, irreversible inhibitor of the Escherchia coli form of S-adenosylmethionine decarboxylase (AdoMet-DC), also acts as a potent inhibitor of the human form of the enzyme. S-Adenosylmethionine 26-32 adenosylmethionine decarboxylase 1 Homo sapiens 197-231 7748194-1 1995 The S-adenosylmethionine (AdoMet) analogue AdoMac [S-(5"-deoxy-5"-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopen ten e], an enzyme-activated, irreversible inhibitor of the Escherchia coli form of S-adenosylmethionine decarboxylase (AdoMet-DC), also acts as a potent inhibitor of the human form of the enzyme. S-Adenosylmethionine 26-32 adenosylmethionine decarboxylase 1 Homo sapiens 233-242 1480164-8 1992 The specificity of labeling of AdoMetDC by this procedure was confirmed by the prevention of 35S-decarboxylated S-adenosylmethionine (AdoMet) binding in the presence of specific AdoMetDC inhibitors [either methylglyoxal bis(guanylhydrazone (MGBG), a reversible inhibitor, or 5"-deoxy-5"-[(2-hydrazinoethyl)methylamino]adenosine (MHZEA), an irreversible inactivator]. S-Adenosylmethionine 112-132 adenosylmethionine decarboxylase 1 Homo sapiens 31-39 1480164-8 1992 The specificity of labeling of AdoMetDC by this procedure was confirmed by the prevention of 35S-decarboxylated S-adenosylmethionine (AdoMet) binding in the presence of specific AdoMetDC inhibitors [either methylglyoxal bis(guanylhydrazone (MGBG), a reversible inhibitor, or 5"-deoxy-5"-[(2-hydrazinoethyl)methylamino]adenosine (MHZEA), an irreversible inactivator]. S-Adenosylmethionine 112-132 adenosylmethionine decarboxylase 1 Homo sapiens 178-186 1480164-8 1992 The specificity of labeling of AdoMetDC by this procedure was confirmed by the prevention of 35S-decarboxylated S-adenosylmethionine (AdoMet) binding in the presence of specific AdoMetDC inhibitors [either methylglyoxal bis(guanylhydrazone (MGBG), a reversible inhibitor, or 5"-deoxy-5"-[(2-hydrazinoethyl)methylamino]adenosine (MHZEA), an irreversible inactivator]. S-Adenosylmethionine 31-37 adenosylmethionine decarboxylase 1 Homo sapiens 178-186