PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21247894-1 2011 The X protein (HBx) of hepatitis B virus (HBV) is involved in the development of hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) promotes the growth of liver cancer cells through altering S-adenosylmethionine homeostasis. S-Adenosylmethionine 220-238 X protein Hepatitis B virus 15-18 21247894-9 2011 Thus, we proposed that HBx activates MAT2A expression through NF-kappaB and CREB signaling pathways to reduce AdoMet production, inhibit hepatoma cell apoptosis, and perhaps enhance HCC development. S-Adenosylmethionine 110-116 X protein Hepatitis B virus 23-26