PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25733650-3 2015 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. S-Adenosylmethionine 71-91 methylenetetrahydrofolate reductase Mus musculus 0-35 25733650-3 2015 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. S-Adenosylmethionine 71-91 methylenetetrahydrofolate reductase Mus musculus 37-42 25733650-3 2015 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. S-Adenosylmethionine 93-96 methylenetetrahydrofolate reductase Mus musculus 0-35 25733650-3 2015 Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. S-Adenosylmethionine 93-96 methylenetetrahydrofolate reductase Mus musculus 37-42 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). S-Adenosylmethionine 184-204 methylenetetrahydrofolate reductase Mus musculus 0-5 17032644-1 2006 Methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) is the sole enzyme responsible for generation of 5-methyltetrahydrofolate, which is required for methionine synthesis and provision of methyl groups via S-adenosylmethionine. S-Adenosylmethionine 210-230 methylenetetrahydrofolate reductase Mus musculus 37-42 26937386-2 2015 Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). S-Adenosylmethionine 99-119 methylenetetrahydrofolate reductase Mus musculus 16-21 26937386-2 2015 Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). S-Adenosylmethionine 121-124 methylenetetrahydrofolate reductase Mus musculus 16-21 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). S-Adenosylmethionine 184-204 methylenetetrahydrofolate reductase Mus musculus 68-73 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). S-Adenosylmethionine 206-209 methylenetetrahydrofolate reductase Mus musculus 0-5 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). S-Adenosylmethionine 206-209 methylenetetrahydrofolate reductase Mus musculus 68-73 14630804-5 2004 With the control diet, the S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) ratio was lower in the liver and brain of Mthfr(+/-) mice than Mthfr(+/+) mice (P<.05). S-Adenosylmethionine 27-47 methylenetetrahydrofolate reductase Mus musculus 128-133 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). S-Adenosylmethionine 188-208 methylenetetrahydrofolate reductase Mus musculus 0-35 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). S-Adenosylmethionine 188-208 methylenetetrahydrofolate reductase Mus musculus 37-42 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). S-Adenosylmethionine 210-213 methylenetetrahydrofolate reductase Mus musculus 0-35 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). S-Adenosylmethionine 210-213 methylenetetrahydrofolate reductase Mus musculus 37-42 14630804-5 2004 With the control diet, the S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) ratio was lower in the liver and brain of Mthfr(+/-) mice than Mthfr(+/+) mice (P<.05). S-Adenosylmethionine 49-52 methylenetetrahydrofolate reductase Mus musculus 128-133 14630804-5 2004 With the control diet, the S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) ratio was lower in the liver and brain of Mthfr(+/-) mice than Mthfr(+/+) mice (P<.05). S-Adenosylmethionine 49-52 methylenetetrahydrofolate reductase Mus musculus 149-154 30408316-5 2019 On both diets, MTHFR deficiency results in decreased S-adenosylmethionine, increased S-adenosylhomocysteine, and decreased betaine with reduced methylation capacity, and changes in expression of several inflammatory or anti-inflammatory mediators (Saa1, Apoa1, and Pon1). S-Adenosylmethionine 53-73 methylenetetrahydrofolate reductase Mus musculus 15-20 32448097-3 2022 MTHFR plays a critical role in the synthesis of S-adenosylmethionine (SAM), a global methyl donor. S-Adenosylmethionine 48-68 methylenetetrahydrofolate reductase Mus musculus 0-5 32448097-3 2022 MTHFR plays a critical role in the synthesis of S-adenosylmethionine (SAM), a global methyl donor. S-Adenosylmethionine 70-73 methylenetetrahydrofolate reductase Mus musculus 0-5