PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30093610-1 2018 Nicotinamide N-methyl transferase (NNMT) transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1MNA). S-Adenosylmethionine 71-94 nicotinamide N-methyltransferase Homo sapiens 0-33 30044909-1 2018 Nicotinamide- N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. S-Adenosylmethionine 138-159 nicotinamide N-methyltransferase Homo sapiens 0-33 30044909-1 2018 Nicotinamide- N-methyltransferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. S-Adenosylmethionine 138-159 nicotinamide N-methyltransferase Homo sapiens 35-39 29731364-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor and, through doing so, can modulate cellular methylation potential to impact diverse epigenetic processes. S-Adenosylmethionine 90-113 nicotinamide N-methyltransferase Homo sapiens 0-32 29731364-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor and, through doing so, can modulate cellular methylation potential to impact diverse epigenetic processes. S-Adenosylmethionine 90-113 nicotinamide N-methyltransferase Homo sapiens 34-38 29731364-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor and, through doing so, can modulate cellular methylation potential to impact diverse epigenetic processes. S-Adenosylmethionine 115-118 nicotinamide N-methyltransferase Homo sapiens 0-32 29731364-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor and, through doing so, can modulate cellular methylation potential to impact diverse epigenetic processes. S-Adenosylmethionine 115-118 nicotinamide N-methyltransferase Homo sapiens 34-38 30148963-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. S-Adenosylmethionine 86-106 nicotinamide N-methyltransferase Homo sapiens 0-32 30148963-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. S-Adenosylmethionine 86-106 nicotinamide N-methyltransferase Homo sapiens 34-38 30148963-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. S-Adenosylmethionine 108-111 nicotinamide N-methyltransferase Homo sapiens 0-32 30148963-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues. S-Adenosylmethionine 108-111 nicotinamide N-methyltransferase Homo sapiens 34-38 30093610-1 2018 Nicotinamide N-methyl transferase (NNMT) transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1MNA). S-Adenosylmethionine 71-94 nicotinamide N-methyltransferase Homo sapiens 35-39 30093610-1 2018 Nicotinamide N-methyl transferase (NNMT) transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1MNA). S-Adenosylmethionine 96-99 nicotinamide N-methyltransferase Homo sapiens 0-33 30093610-1 2018 Nicotinamide N-methyl transferase (NNMT) transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1MNA). S-Adenosylmethionine 96-99 nicotinamide N-methyltransferase Homo sapiens 35-39 28515364-4 2017 NNMT depletes S-adenosyl methionine (SAM), a methyl donor generated from methionine. S-Adenosylmethionine 14-35 nicotinamide N-methyltransferase Homo sapiens 0-4 29320176-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor. S-Adenosylmethionine 148-151 nicotinamide N-methyltransferase Homo sapiens 0-32 29320176-1 2018 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor. S-Adenosylmethionine 148-151 nicotinamide N-methyltransferase Homo sapiens 34-38 28726800-1 2017 Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). S-Adenosylmethionine 66-89 nicotinamide N-methyltransferase Homo sapiens 0-32 28726800-1 2017 Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). S-Adenosylmethionine 66-89 nicotinamide N-methyltransferase Homo sapiens 34-38 28726800-1 2017 Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). S-Adenosylmethionine 91-94 nicotinamide N-methyltransferase Homo sapiens 0-32 28726800-1 2017 Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). S-Adenosylmethionine 91-94 nicotinamide N-methyltransferase Homo sapiens 34-38 28726800-5 2017 Lentivirus-mediated knockdown of Nnmt in the dorsomedial striatum (DMS) attenuated cocaine conditioned place preference (CPP) reward, but increased striatal SAM/SAH ratio levels as well as Rac1 and RhoA activities. S-Adenosylmethionine 157-160 nicotinamide N-methyltransferase Homo sapiens 33-37 28515364-4 2017 NNMT depletes S-adenosyl methionine (SAM), a methyl donor generated from methionine. S-Adenosylmethionine 37-40 nicotinamide N-methyltransferase Homo sapiens 0-4 28420001-3 2017 Nicotinamide N-methyltransferase (NNMT) decreases histone methylation in several cancer cells by altering the cellular ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). S-Adenosylmethionine 128-148 nicotinamide N-methyltransferase Homo sapiens 0-32 28420001-3 2017 Nicotinamide N-methyltransferase (NNMT) decreases histone methylation in several cancer cells by altering the cellular ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). S-Adenosylmethionine 128-148 nicotinamide N-methyltransferase Homo sapiens 34-38 28420001-3 2017 Nicotinamide N-methyltransferase (NNMT) decreases histone methylation in several cancer cells by altering the cellular ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). S-Adenosylmethionine 150-153 nicotinamide N-methyltransferase Homo sapiens 0-32 28420001-3 2017 Nicotinamide N-methyltransferase (NNMT) decreases histone methylation in several cancer cells by altering the cellular ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). S-Adenosylmethionine 150-153 nicotinamide N-methyltransferase Homo sapiens 34-38 27570878-2 2016 Employing the cofactor S-adenosyl-l-methionine, NNMT transfers a methyl group to the pyridine nitrogen of nicotinamide to generate N-methylnicotinamide. S-Adenosylmethionine 23-46 nicotinamide N-methyltransferase Homo sapiens 48-52 23455543-2 2013 Here we show using metabolomics that NNMT impairs the methylation potential of cancer cells by consuming methyl units from S-adenosyl methionine to create the stable metabolic product 1-methylnicotinamide. S-Adenosylmethionine 123-144 nicotinamide N-methyltransferase Homo sapiens 37-41 24717514-4 2014 NNMT methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. S-Adenosylmethionine 48-68 nicotinamide N-methyltransferase Homo sapiens 0-4 24717514-4 2014 NNMT methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. S-Adenosylmethionine 70-73 nicotinamide N-methyltransferase Homo sapiens 0-4 26571212-4 2015 Specifically, in naive hESCs, NNMT and its enzymatic product 1-methylnicotinamide are highly upregulated, and NNMT is required for low S-adenosyl methionine (SAM) levels and the H3K27me3 repressive state. S-Adenosylmethionine 135-156 nicotinamide N-methyltransferase Homo sapiens 110-114 26571212-4 2015 Specifically, in naive hESCs, NNMT and its enzymatic product 1-methylnicotinamide are highly upregulated, and NNMT is required for low S-adenosyl methionine (SAM) levels and the H3K27me3 repressive state. S-Adenosylmethionine 158-161 nicotinamide N-methyltransferase Homo sapiens 110-114 34377057-1 2021 Nicotinamide N-methyltransferase (NNMT), a key cytoplasmic protein in the human body, is accountable to catalyze the nicotinamide (NCA) N1-methylation through S-adenosyl-L-methionine (SAM) as a methyl donor, which has been linked to many diseases. S-Adenosylmethionine 159-182 nicotinamide N-methyltransferase Homo sapiens 0-32 15728403-2 2005 N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. S-Adenosylmethionine 207-228 nicotinamide N-methyltransferase Homo sapiens 103-135 15728403-2 2005 N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. S-Adenosylmethionine 207-228 nicotinamide N-methyltransferase Homo sapiens 137-141 15728403-2 2005 N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. S-Adenosylmethionine 230-233 nicotinamide N-methyltransferase Homo sapiens 103-135 15728403-2 2005 N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. S-Adenosylmethionine 230-233 nicotinamide N-methyltransferase Homo sapiens 137-141 8182091-12 1994 Human liver NNMT and transfected COS-1 cell NNMT had apparent Km values for the two cosubstrates for the reaction, nicotinamide and S-adenosyl-L-methionine, of 0.43 and 0.38 mM and of 1.8 and 2.2 microM, respectively. S-Adenosylmethionine 132-155 nicotinamide N-methyltransferase Homo sapiens 12-16 8182091-12 1994 Human liver NNMT and transfected COS-1 cell NNMT had apparent Km values for the two cosubstrates for the reaction, nicotinamide and S-adenosyl-L-methionine, of 0.43 and 0.38 mM and of 1.8 and 2.2 microM, respectively. S-Adenosylmethionine 132-155 nicotinamide N-methyltransferase Homo sapiens 44-48 34655178-8 2021 We speculate that depletion of NNMT promotes histone methylation and leads to tumor suppression because NNMT consumes S-adenosyl methionine (SAM), which is an essential methylation cofactor. S-Adenosylmethionine 118-139 nicotinamide N-methyltransferase Homo sapiens 104-108 34655178-8 2021 We speculate that depletion of NNMT promotes histone methylation and leads to tumor suppression because NNMT consumes S-adenosyl methionine (SAM), which is an essential methylation cofactor. S-Adenosylmethionine 141-144 nicotinamide N-methyltransferase Homo sapiens 31-35 34655178-8 2021 We speculate that depletion of NNMT promotes histone methylation and leads to tumor suppression because NNMT consumes S-adenosyl methionine (SAM), which is an essential methylation cofactor. S-Adenosylmethionine 141-144 nicotinamide N-methyltransferase Homo sapiens 104-108 34439880-1 2021 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of nicotinamide, using S-adenosyl-L-methionine as the methyl donor. S-Adenosylmethionine 100-123 nicotinamide N-methyltransferase Homo sapiens 0-32 34439880-1 2021 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of nicotinamide, using S-adenosyl-L-methionine as the methyl donor. S-Adenosylmethionine 100-123 nicotinamide N-methyltransferase Homo sapiens 34-38 21823666-1 2011 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor. S-Adenosylmethionine 122-145 nicotinamide N-methyltransferase Homo sapiens 0-32 21823666-1 2011 Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor. S-Adenosylmethionine 122-145 nicotinamide N-methyltransferase Homo sapiens 34-38 2311261-5 1990 Apparent Km values of human liver NNMT for nicotinamide and Ado-Met were 347 and 1.76 mumol/l, respectively. S-Adenosylmethionine 60-67 nicotinamide N-methyltransferase Homo sapiens 34-38 34424711-3 2021 The development of small-molecule NNMT inhibitors has gained interest in recent years, with the most potent inhibitors sharing structural features based on elements of the nicotinamide substrate and the S-adenosyl-l-methionine (SAM) cofactor. S-Adenosylmethionine 203-226 nicotinamide N-methyltransferase Homo sapiens 34-38 34424711-3 2021 The development of small-molecule NNMT inhibitors has gained interest in recent years, with the most potent inhibitors sharing structural features based on elements of the nicotinamide substrate and the S-adenosyl-l-methionine (SAM) cofactor. S-Adenosylmethionine 228-231 nicotinamide N-methyltransferase Homo sapiens 34-38 34704059-1 2021 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. S-Adenosylmethionine 105-128 nicotinamide N-methyltransferase Homo sapiens 0-32 34704059-1 2021 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. S-Adenosylmethionine 105-128 nicotinamide N-methyltransferase Homo sapiens 34-38 34704059-1 2021 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. S-Adenosylmethionine 130-133 nicotinamide N-methyltransferase Homo sapiens 0-32 34704059-1 2021 Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. S-Adenosylmethionine 130-133 nicotinamide N-methyltransferase Homo sapiens 34-38 34704059-7 2021 Interestingly, substrate competition experiments reveal that these cyclic peptide inhibitors are noncompetitive with either SAM or NA indicating they may be the first allosteric inhibitors reported for NNMT. S-Adenosylmethionine 124-127 nicotinamide N-methyltransferase Homo sapiens 202-206 34377057-1 2021 Nicotinamide N-methyltransferase (NNMT), a key cytoplasmic protein in the human body, is accountable to catalyze the nicotinamide (NCA) N1-methylation through S-adenosyl-L-methionine (SAM) as a methyl donor, which has been linked to many diseases. S-Adenosylmethionine 159-182 nicotinamide N-methyltransferase Homo sapiens 34-38 34377057-1 2021 Nicotinamide N-methyltransferase (NNMT), a key cytoplasmic protein in the human body, is accountable to catalyze the nicotinamide (NCA) N1-methylation through S-adenosyl-L-methionine (SAM) as a methyl donor, which has been linked to many diseases. S-Adenosylmethionine 184-187 nicotinamide N-methyltransferase Homo sapiens 0-32 34377057-1 2021 Nicotinamide N-methyltransferase (NNMT), a key cytoplasmic protein in the human body, is accountable to catalyze the nicotinamide (NCA) N1-methylation through S-adenosyl-L-methionine (SAM) as a methyl donor, which has been linked to many diseases. S-Adenosylmethionine 184-187 nicotinamide N-methyltransferase Homo sapiens 34-38 33668468-1 2021 Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). S-Adenosylmethionine 109-130 nicotinamide N-methyltransferase Homo sapiens 0-32 33453420-3 2021 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) using the universal methyl donor S-adenosyl methionine (SAM), directly linking one-carbon metabolism with a cell"s methylation balance and nicotinamide adenine dinucleotide (NAD+) levels. S-Adenosylmethionine 148-169 nicotinamide N-methyltransferase Homo sapiens 0-32 33453420-3 2021 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) using the universal methyl donor S-adenosyl methionine (SAM), directly linking one-carbon metabolism with a cell"s methylation balance and nicotinamide adenine dinucleotide (NAD+) levels. S-Adenosylmethionine 148-169 nicotinamide N-methyltransferase Homo sapiens 34-38 33453420-3 2021 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) using the universal methyl donor S-adenosyl methionine (SAM), directly linking one-carbon metabolism with a cell"s methylation balance and nicotinamide adenine dinucleotide (NAD+) levels. S-Adenosylmethionine 171-174 nicotinamide N-methyltransferase Homo sapiens 0-32 33453420-3 2021 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) using the universal methyl donor S-adenosyl methionine (SAM), directly linking one-carbon metabolism with a cell"s methylation balance and nicotinamide adenine dinucleotide (NAD+) levels. S-Adenosylmethionine 171-174 nicotinamide N-methyltransferase Homo sapiens 34-38 33668468-1 2021 Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). S-Adenosylmethionine 109-130 nicotinamide N-methyltransferase Homo sapiens 34-38 33668468-1 2021 Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). S-Adenosylmethionine 132-135 nicotinamide N-methyltransferase Homo sapiens 0-32 33668468-1 2021 Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). S-Adenosylmethionine 132-135 nicotinamide N-methyltransferase Homo sapiens 34-38 33523930-4 2021 Despite the elevated levels of MNA in T cells, the expression of nicotinamide N-methyltransferase, the enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to nicotinamide, was restricted to fibroblasts and tumor cells. S-Adenosylmethionine 161-181 nicotinamide N-methyltransferase Homo sapiens 65-97 31724854-1 2019 Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds. S-Adenosylmethionine 88-108 nicotinamide N-methyltransferase Homo sapiens 0-32 32622979-3 2020 Nicotinamide N-methyltransferase (NNMT) is a major metabolic enzyme involved in epigenetic regulation through catalysis of methyl transfer from the cofactor S-adenosyl-L-methionine onto nicotinamide and other pyridines. S-Adenosylmethionine 157-180 nicotinamide N-methyltransferase Homo sapiens 0-32 32622979-3 2020 Nicotinamide N-methyltransferase (NNMT) is a major metabolic enzyme involved in epigenetic regulation through catalysis of methyl transfer from the cofactor S-adenosyl-L-methionine onto nicotinamide and other pyridines. S-Adenosylmethionine 157-180 nicotinamide N-methyltransferase Homo sapiens 34-38 32651404-2 2020 NNMT methylates nicotinamide to N1-methylnicotidamide (MNA-1) using S-adenosyl methionine. S-Adenosylmethionine 68-89 nicotinamide N-methyltransferase Homo sapiens 0-4 31724854-1 2019 Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds. S-Adenosylmethionine 88-108 nicotinamide N-methyltransferase Homo sapiens 34-38 31494172-6 2019 MNAM is one of potential therapeutic factor, which produced by nicotinamide N-methyltransferase (NNMT) via consumption of S-adenosyl methionine (SAM) and nicotinamide. S-Adenosylmethionine 122-143 nicotinamide N-methyltransferase Homo sapiens 63-95 31494172-6 2019 MNAM is one of potential therapeutic factor, which produced by nicotinamide N-methyltransferase (NNMT) via consumption of S-adenosyl methionine (SAM) and nicotinamide. S-Adenosylmethionine 122-143 nicotinamide N-methyltransferase Homo sapiens 97-101 31494172-6 2019 MNAM is one of potential therapeutic factor, which produced by nicotinamide N-methyltransferase (NNMT) via consumption of S-adenosyl methionine (SAM) and nicotinamide. S-Adenosylmethionine 145-148 nicotinamide N-methyltransferase Homo sapiens 63-95 31494172-6 2019 MNAM is one of potential therapeutic factor, which produced by nicotinamide N-methyltransferase (NNMT) via consumption of S-adenosyl methionine (SAM) and nicotinamide. S-Adenosylmethionine 145-148 nicotinamide N-methyltransferase Homo sapiens 97-101 31043742-7 2019 Expression of NNMT in CAFs led to depletion of S-adenosyl methionine and reduction in histone methylation associated with widespread gene expression changes in the tumour stroma. S-Adenosylmethionine 47-68 nicotinamide N-methyltransferase Homo sapiens 14-18 30933557-1 2019 Nicotinamide N-methyltransferase (NNMT) catalyzes the S-adenosyl-l-methionine-dependent methylation of nicotinamide to form N-methylnicotinamide. S-Adenosylmethionine 54-77 nicotinamide N-methyltransferase Homo sapiens 0-32 30933557-1 2019 Nicotinamide N-methyltransferase (NNMT) catalyzes the S-adenosyl-l-methionine-dependent methylation of nicotinamide to form N-methylnicotinamide. S-Adenosylmethionine 54-77 nicotinamide N-methyltransferase Homo sapiens 34-38 31589440-1 2019 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). S-Adenosylmethionine 112-132 nicotinamide N-methyltransferase Homo sapiens 0-32 31589440-1 2019 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). S-Adenosylmethionine 112-132 nicotinamide N-methyltransferase Homo sapiens 34-38 31589440-1 2019 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). S-Adenosylmethionine 134-137 nicotinamide N-methyltransferase Homo sapiens 0-32 31589440-1 2019 Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that methylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM). S-Adenosylmethionine 134-137 nicotinamide N-methyltransferase Homo sapiens 34-38 31589440-4 2019 The reported nicotinamide-SAM conjugate (named NS1) features an alkyne as a key design element that closely mimics the linear, 180 transition state geometry found in the NNMT-catalyzed SAM NAM methyl transfer reaction. S-Adenosylmethionine 26-29 nicotinamide N-methyltransferase Homo sapiens 171-175 31589440-4 2019 The reported nicotinamide-SAM conjugate (named NS1) features an alkyne as a key design element that closely mimics the linear, 180 transition state geometry found in the NNMT-catalyzed SAM NAM methyl transfer reaction. S-Adenosylmethionine 186-189 nicotinamide N-methyltransferase Homo sapiens 171-175