PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33510167-4 2021 We show that oxidative stress activates FOXO3 and its transcriptional target glycine-N-methyltransferase (GNMT) whose upregulation triggers depletion of s-adenosylmethionine (SAM), a key co-substrate involved in methyl group transfer reactions. S-Adenosylmethionine 153-173 forkhead box O3 Homo sapiens 40-45 33510167-4 2021 We show that oxidative stress activates FOXO3 and its transcriptional target glycine-N-methyltransferase (GNMT) whose upregulation triggers depletion of s-adenosylmethionine (SAM), a key co-substrate involved in methyl group transfer reactions. S-Adenosylmethionine 175-178 forkhead box O3 Homo sapiens 40-45