PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12163655-0	2002	In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.	S-Adenosylmethionine	148-168	cystathionine beta-synthase	Mus musculus	7-34	
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	S-Adenosylmethionine	65-85	cystathionine beta-synthase	Mus musculus	120-123	
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	S-Adenosylmethionine	65-85	cystathionine beta-synthase	Mus musculus	173-176	
31539805-7	2020	S-adenosylmethionine administration enhanced Nos2 mRNA expression and cystathionine beta-synthase nitration and triggered homocysteine accumulation in acute pancreatitis.	S-Adenosylmethionine	0-20	cystathionine beta-synthase	Mus musculus	70-97	
31539805-10	2020	In conclusion, tyrosine-nitration of cystathionine beta-synthase blockades the trans-sulfuration pathway in acute pancreatitis promoting homocysteine accumulation upon S-adenosylmethionine treatment.	S-Adenosylmethionine	168-188	cystathionine beta-synthase	Mus musculus	37-64	
20955694-5	2011	CBS enzyme activity is allosterically regulated by the endogenous activator S-adenosyl methionine.	S-Adenosylmethionine	78-97	cystathionine beta-synthase	Mus musculus	0-3	
20955694-9	2011	We demonstrate that CBS enzyme from endogenous sources can be activated by S-adenosyl methionine to a greater extent compared to recombinant enzyme, suggesting greater potential for activation than previously anticipated.	S-Adenosylmethionine	75-96	cystathionine beta-synthase	Mus musculus	20-23	
20036517-8	2010	CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein.	S-Adenosylmethionine	189-209	cystathionine beta-synthase	Mus musculus	271-274