PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22100631-8	2012	Studies using liver cells have demonstrated that S-adenosyl methionine (SAM), which is a product of folate metabolism, regulates the expression and catalytic activity of CYP2E1.	S-Adenosylmethionine	49-70	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	170-176	
22100631-8	2012	Studies using liver cells have demonstrated that S-adenosyl methionine (SAM), which is a product of folate metabolism, regulates the expression and catalytic activity of CYP2E1.	S-Adenosylmethionine	72-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	170-176	
20238404-0	2010	Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury.	S-Adenosylmethionine	28-51	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	73-92	
15763544-0	2005	Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine.	S-Adenosylmethionine	52-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	14-20	
15763544-1	2005	The objective of this work was to evaluate the possible in vitro interactions of S-adenosyl-l-methionine (SAM) and its metabolites S-(5"-Adenosyl)-l-homocysteine (SAH), 5"-Deoxy-5"-(methylthio)adenosine (MTA) and methionine with cytochrome P450 enzymes, in particular CYP2E1.	S-Adenosylmethionine	81-104	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	268-274	
15763544-1	2005	The objective of this work was to evaluate the possible in vitro interactions of S-adenosyl-l-methionine (SAM) and its metabolites S-(5"-Adenosyl)-l-homocysteine (SAH), 5"-Deoxy-5"-(methylthio)adenosine (MTA) and methionine with cytochrome P450 enzymes, in particular CYP2E1.	S-Adenosylmethionine	106-109	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	268-274	
15763544-5	2005	However, SAM inhibited the catalytic activity of CYP2E1 with typical substrates such as p-nitrophenol, ethanol, and dimethylnitrosamine, with an IC(50) around 1.5-5mM.	S-Adenosylmethionine	9-12	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	49-55	
15763544-9	2005	SAM also inhibited CYP2E1 catalytic activity in intact HepG2 cells engineered to express CYP2E1.	S-Adenosylmethionine	0-3	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	19-25	
15763544-9	2005	SAM also inhibited CYP2E1 catalytic activity in intact HepG2 cells engineered to express CYP2E1.	S-Adenosylmethionine	0-3	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95