PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28801761-5	2017	The alkaloid was able to inhibit the peritonitis induced by carrageenan, decreasing mainly the migration of polymorphonuclear cells, without altering the mononuclear cell number, and reduced the levels of TNF-alpha and IL-1beta in the peritoneum.	Alkaloids	4-12	tumor necrosis factor	Homo sapiens	205-214	
34269666-11	2021	In this review, the main natural compounds that are derived from alkaloids, flavonoids, terpene, and polyphenols as promising TNF-alpha inhibitors will be discussed.	Alkaloids	65-74	tumor necrosis factor	Homo sapiens	126-135	
8824940-2	1995	This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflammatory cytokines, interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-alpha), by Staphylococcus aureus Cowan 1 (SAC)-stimulated human peripheral blood mononuclear cells.	Alkaloids	65-74	tumor necrosis factor	Homo sapiens	216-225	
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	81-90	tumor necrosis factor	Homo sapiens	140-149	
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	211-220	tumor necrosis factor	Homo sapiens	140-149	
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	tumor necrosis factor	Homo sapiens	135-144