PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21372424-10	2011	In conclusion, some herbal alkaloids like harmine, in spite of lacking antioxidative property, have potential as anti-inflammatory agents that strongly suppress TNF-alpha and NO production by a unique mechanism.	Alkaloids	27-36	tumor necrosis factor	Mus musculus	161-170	
22482398-3	2012	The effect of the alkaloids on tumor necrosis factor alpha (TNF-alpha) was measured in RAW264.7 macrophage cells.	Alkaloids	18-27	tumor necrosis factor	Mus musculus	31-58	
22482398-3	2012	The effect of the alkaloids on tumor necrosis factor alpha (TNF-alpha) was measured in RAW264.7 macrophage cells.	Alkaloids	18-27	tumor necrosis factor	Mus musculus	60-69	
24594217-8	2014	Moreover, total alkaloids decreased the production of the tumor necrosis factor alpha and nitric oxide in the serum and bronchoalveolar lavage fluid.	Alkaloids	16-25	tumor necrosis factor	Mus musculus	58-85	
24594217-11	2014	This protective effect of total alkaloids seems to result from inhibition of nuclear factor kappa B activation, which causes the reduction of inflammatory markers such as tumor necrosis factor alpha and inducible nitric oxide synthase.	Alkaloids	32-41	tumor necrosis factor	Mus musculus	171-198	
23098900-5	2013	The anti-inflammatory activity of the crude extracts and the five alkaloids were tested by measuring the amount of TNF-alpha and IL-6 released from LPS stimulated RAW264 cell via ELISA.	Alkaloids	66-75	tumor necrosis factor	Mus musculus	115-124	
21372424-0	2011	Inhibitory effects of herbal alkaloids on the tumor necrosis factor-alpha and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages.	Alkaloids	29-38	tumor necrosis factor	Mus musculus	46-73	
21372424-2	2011	Since less attention has been paid to alkaloids in the diets than to polyphenols in this regard, we aimed at investigating anti-inflammatory activity of herb-derived alkaloids through suppression of TNF-alpha and NO production in lipopolysaccharide (LPS)-stimulated mouse RAW264 and/or human THP-1 cells.	Alkaloids	166-175	tumor necrosis factor	Mus musculus	199-208	
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	125-152	
19481591-3	2009	The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands.	Alkaloids	4-13	tumor necrosis factor	Mus musculus	24-33	
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	151-178	
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	180-189	
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	154-163	
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	245-254	
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	283-292	
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	294-321	
30121232-6	2018	Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.	Alkaloids	33-41	tumor necrosis factor	Mus musculus	161-170