PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35335376-3 2022 As an important source of cholinesterase inhibitors, alkaloids in natural products have high potential value in terms of exerting pharmacological activities. Alkaloids 53-62 butyrylcholinesterase Homo sapiens 26-40 698301-2 1978 Butyrylcholine esterase found to increase the hydrolysis rate of all the alkaloid esters studied with the increase of acyl radical either to valerates (for ephedrine and pseudo-ephedrine derivatives), or to butyrates (for the rest alkaloids) and then it did not considerably change under further elongation of carbon chain up to valerate. Alkaloids 231-240 butyrylcholinesterase Homo sapiens 0-23 33652057-11 2021 Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties. Alkaloids 99-108 butyrylcholinesterase Homo sapiens 186-200 33327436-6 2020 The cholinesterase inhibitory activity of STR extracts and its alkaloids was determined using the Ellman assay. Alkaloids 63-72 butyrylcholinesterase Homo sapiens 4-18 33401696-0 2021 Alkaloids Analysis of Habranthus cardenasianus (Amaryllidaceae), Anti-Cholinesterase Activity and Biomass Production by Propagation Strategies. Alkaloids 0-9 butyrylcholinesterase Homo sapiens 70-84 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 butyrylcholinesterase Homo sapiens 113-134 32920358-3 2020 While geissospermine inhibited only butyrylcholinesterase (BChE), the other alkaloids behaved as non-selective inhibitors of acetylcholinesterase (AChE) and BChE. Alkaloids 76-85 butyrylcholinesterase Homo sapiens 157-161 32920358-10 2020 In addition, the ability to inhibit hAChE and hBChE, with approximate inhibitory potencies, accredits this alkaloid for therapeutic use in the moderate to severe phase of AD. Alkaloids 107-115 butyrylcholinesterase Homo sapiens 46-51 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 butyrylcholinesterase Homo sapiens 136-140 31220673-11 2019 The molecular modeling studies with AChE and BChE have shown that both alkaloids were tightly packed inside the active site gorge (site 1) via multiple pi-pi and cation-pi interactions. Alkaloids 71-80 butyrylcholinesterase Homo sapiens 45-49 31220673-1 2019 Alkaloids have always been a great source of cholinesterase inhibitors. Alkaloids 0-9 butyrylcholinesterase Homo sapiens 45-59 30801949-0 2019 Clinanthus microstephium, an Amaryllidaceae Species with Cholinesterase Inhibitor Alkaloids: Structure-Activity Analysis of Haemanthamine Skeleton Derivatives. Alkaloids 82-91 butyrylcholinesterase Homo sapiens 57-71 31152736-0 2019 Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds. Alkaloids 125-133 butyrylcholinesterase Homo sapiens 75-96 31152736-3 2019 As a result, a set of new, selective inhibitors of human BChE were identified from natural products with solanaceous alkaloid scaffolds. Alkaloids 117-125 butyrylcholinesterase Homo sapiens 57-61 29756568-5 2019 In this review, the use of aporphines in nature for treating Alzheimer"s disease, alkaloids isolated from natural and/or synthetic sources have been used principally as cholinesterase inhibitors (acetyl- and butyrylcholinesterase) as galantamine, for instance, though its use has been questioned for being slightly effective or marginal. Alkaloids 82-91 butyrylcholinesterase Homo sapiens 169-183 30380451-0 2019 Synthesis and 2D-QSAR study of dispiropyrrolodinyl-oxindole based alkaloids as cholinesterase inhibitors. Alkaloids 66-75 butyrylcholinesterase Homo sapiens 79-93 21941892-6 2011 Significant cholinesterase inhibitory activity was demonstrated by the alkaloid extract of N. undulata (IC50,(HuAChE) = 14.3 +/- 1.2 microg/mL; IC50,(HuBuChE) = 33.9 +/- 1.9 microg/mL). Alkaloids 71-79 butyrylcholinesterase Homo sapiens 12-26 25636869-2 2015 All the alkaloids except for pumiloside (10) showed strong to weak BChE inhibitory effect with IC50 values ranging between 1.02-168.55 muM. Alkaloids 8-17 butyrylcholinesterase Homo sapiens 67-71 26084651-0 2015 Alkaloids from hydrastidis canadensis and their cholinesterase and prolyl oligopeptidase inhibitory. Alkaloids 0-9 butyrylcholinesterase Homo sapiens 48-62 24819955-0 2014 Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine. Alkaloids 107-115 butyrylcholinesterase Homo sapiens 50-71 24236981-4 2013 This review aims to summarize recent advances in current knowledge on alkaloids as AChE and BChE inhibitors, highlighting structure-activity relationship (SAR) and docking studies. Alkaloids 70-79 butyrylcholinesterase Homo sapiens 92-96 23618192-2 2013 Applying this on-line method to the identification of BChE inhibitors in a Plumula nelumbinis sample, three alkaloids, namely liensinine, isoliensinine, and neferine, have been detected as having a strong BChE inhibition activity for the first time; in addition, norisoliensinine and 6-hydroxynorisoliensinine were proposed as two new compounds identified by their UV and MS data. Alkaloids 108-117 butyrylcholinesterase Homo sapiens 54-58 23618192-2 2013 Applying this on-line method to the identification of BChE inhibitors in a Plumula nelumbinis sample, three alkaloids, namely liensinine, isoliensinine, and neferine, have been detected as having a strong BChE inhibition activity for the first time; in addition, norisoliensinine and 6-hydroxynorisoliensinine were proposed as two new compounds identified by their UV and MS data. Alkaloids 108-117 butyrylcholinesterase Homo sapiens 205-209 17193337-0 2006 New cholinesterase-inhibiting triterpenoid alkaloids from Buxus hyrcana. Alkaloids 43-52 butyrylcholinesterase Homo sapiens 4-18 18069241-2 2007 Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively]. Alkaloids 10-19 butyrylcholinesterase Homo sapiens 104-108 18069241-3 2007 While the rest of the alkaloids did not show any significant inhibition against AChE, three of the alkaloids, namely retamine, sparteine, and yohimbine, exerted a noteworthy anti-BChE effect as compared to galanthamine, the reference drug. Alkaloids 99-108 butyrylcholinesterase Homo sapiens 179-183 15725500-0 2005 Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine. Alkaloids 71-80 butyrylcholinesterase Homo sapiens 32-53