PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28899501-10	2017	The P-gp functional studies showed that these three alkaloids increased the accumulation of P-gp substrates, calcein-AM (C-AM) and rhodamine123 (Rho 123) in K562/Adr cells, while this effect was not seen in drug sensitive parental K562 cells.	Alkaloids	52-61	phosphoglycolate phosphatase	Homo sapiens	4-8	
28899501-10	2017	The P-gp functional studies showed that these three alkaloids increased the accumulation of P-gp substrates, calcein-AM (C-AM) and rhodamine123 (Rho 123) in K562/Adr cells, while this effect was not seen in drug sensitive parental K562 cells.	Alkaloids	52-61	phosphoglycolate phosphatase	Homo sapiens	92-96	
28899501-12	2017	CONCLUSION: The alkaloids reversed MDR via the inhibition of P-gp function.	Alkaloids	16-25	phosphoglycolate phosphatase	Homo sapiens	61-65	
28675836-0	2017	Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.	Alkaloids	8-17	phosphoglycolate phosphatase	Homo sapiens	21-25	
28675836-7	2017	Apart from this, there exist a large number of natural alkaloids possessing potent inhibition of P-gp efflux pump and other related pumps responsible for the development of resistance.	Alkaloids	55-64	phosphoglycolate phosphatase	Homo sapiens	97-101	
28675836-9	2017	The present review provides a comprehensive account on natural alkaloids possessing P-gp inhibition activity and their potential for multidrug resistance reversal in cancer.	Alkaloids	63-72	phosphoglycolate phosphatase	Homo sapiens	84-88	
26272549-8	2015	Thus, Panax ginseng facilitated P-gp-mediated efflflux of toxic Aconitum carmichaeli alkaloids and restricted their intestinal absorption without inflfluencing other active components.	Alkaloids	85-94	phosphoglycolate phosphatase	Homo sapiens	32-36	
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	phosphoglycolate phosphatase	Homo sapiens	149-153	
20739156-6	2011	The results showed that among these three isolated alkaloids; stemofoline exhibited the most potent effect in vitro in the reversal of P-gp-mediated MDR.	Alkaloids	51-60	phosphoglycolate phosphatase	Homo sapiens	135-139	
19035304-2	2008	The tested alkaloids were evaluated for multidrug resistance (MDR)-reversing activity on human Pgp-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay.	Alkaloids	11-20	phosphoglycolate phosphatase	Homo sapiens	95-98