PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32955004-11	2021	Interestingly, the therapeutic impact of alkaloids against blood glucose pathogenesis is mediated through a variety of signaling cascades and pathways, via inhibiting or stimulating a diversity of systems such as inhibition of alpha-glucosidase enzyme, blockade of PTP-1B, deactivation of DPP-IV, increasing insulin sensitivity and modulating the oxidative stress.	Alkaloids	41-50	dipeptidyl peptidase 4	Homo sapiens	289-295	
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	79-85	
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	120-126	
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	120-126	
29172693-4	2017	Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors.	Alkaloids	82-91	dipeptidyl peptidase 4	Homo sapiens	96-102	
29172693-5	2017	Materials & methods: The DPP-IV inhibition of Ephedra"s alkaloids was determined via a competitive-binding assay.	Alkaloids	60-69	dipeptidyl peptidase 4	Homo sapiens	29-35	
29172693-8	2017	CONCLUSION: Further computational analysis shows how Ephedra"s alkaloids could be used as promising lead molecules for designing more potent and selective DPP-IV inhibitors.	Alkaloids	63-72	dipeptidyl peptidase 4	Homo sapiens	155-161