PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8982502-16 1996 These results suggest that whereas the aporphine structure shared by these alkaloids is responsible for their selectively of action for the alpha 1A-adrenoceptor subtype in rat cerebral cortex, defined functional groups, namely the 2-hydroxy function, induces a significant increase in alpha 1A-subtype selectivity and affinity. Alkaloids 75-84 adrenoceptor alpha 1A Rattus norvegicus 140-161