PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16442763-6	2006	Therefore, this paper indicate that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.	Alkaloids	46-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	262-278	
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	230-246	
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	248-253	
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	230-246	
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	248-253	
35209140-7	2022	The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2.	Alkaloids	4-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-98	
35209140-7	2022	The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2.	Alkaloids	4-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	100-105	
28059042-4	2018	Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo.	Alkaloids	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91	
28059042-5	2018	In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery.	Alkaloids	49-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69	
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101	
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108