PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 prostaglandin-endoperoxide synthase 2 Homo sapiens 230-246 16442763-6 2006 Therefore, this paper indicate that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2. Alkaloids 46-55 prostaglandin-endoperoxide synthase 2 Homo sapiens 262-278 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 prostaglandin-endoperoxide synthase 2 Homo sapiens 248-253 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 prostaglandin-endoperoxide synthase 2 Homo sapiens 230-246 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 prostaglandin-endoperoxide synthase 2 Homo sapiens 248-253 35209140-7 2022 The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2. Alkaloids 4-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 82-98 35209140-7 2022 The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2. Alkaloids 4-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 100-105 28059042-4 2018 Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo. Alkaloids 0-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 86-91 28059042-5 2018 In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery. Alkaloids 49-58 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 28869563-8 2017 The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6). Alkaloids 43-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 96-101 28869563-8 2017 The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6). Alkaloids 43-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 103-108