PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16635744-6	2006	Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by these alkaloids.	Alkaloids	73-82	caspase 3	Homo sapiens	14-23	
23238299-5	2013	The alkaloids induced apoptosis in MDR cells which was accompanied by an activation of caspase-3, -8,-6/9, and phosphatidyl serine (PS) exposure.	Alkaloids	4-13	caspase 3	Homo sapiens	87-96	
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	caspase 3	Homo sapiens	227-236	
16442763-6	2006	Therefore, this paper indicate that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.	Alkaloids	46-55	caspase 3	Homo sapiens	248-257	
16635744-5	2006	In addition, both caspase-9 and caspase-3 were also time-dependently activated upon treatment with the alkaloids.	Alkaloids	103-112	caspase 3	Homo sapiens	32-41	
16635744-7	2006	The results suggest that these three alkaloids induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, through mitochondrial dysfunction.	Alkaloids	37-46	caspase 3	Homo sapiens	116-125	
15648263-0	2004	Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.	Alkaloids	7-15	caspase 3	Homo sapiens	124-133	
28059041-6	2018	In conclusion, this kind of alkaloids has extensive antitumor activity, and there are several main mechanisms of their antitumor activity, including the Hedgehog signaling pathway, caspase-3 dependent apoptosis, cell cycle, and autophagy.	Alkaloids	28-37	caspase 3	Homo sapiens	181-190	
12142990-5	2002	Western blotting analysis reveals that the two alkaloids induce cleavage of the poly(ADP-ribose) polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate.	Alkaloids	47-56	caspase 3	Homo sapiens	145-154	
30008816-9	2018	Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells.	Alkaloids	0-8	caspase 3	Homo sapiens	40-49	
29992112-6	2018	Jurkat cells treated with alkaloids extract at sub-lethal concentration showed DNA fragmentation, enhancement in caspase-3 activity and phosphatidylserine translocation (apoptosis indicator) compared to control cells.	Alkaloids	26-35	caspase 3	Homo sapiens	113-122