PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33781874-7	2021	We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis.	Alkaloids	149-158	NFE2 like bZIP transcription factor 2	Homo sapiens	277-320	
33781874-7	2021	We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis.	Alkaloids	149-158	NFE2 like bZIP transcription factor 2	Homo sapiens	322-326	
32661875-2	2020	Trigonelline is one of the major alkaloids in raw coffee which has been recently introduced as potent inhibitor of Nrf2.	Alkaloids	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119	
30703480-10	2019	In some alkaloids, activation of the nuclear factor Nrf2 pathway was documented to be the grounds for inhibition of NADPH-oxidase.	Alkaloids	8-17	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56	
30703480-11	2019	Interestingly, many alkaloids can behave both as anti-oxidants and pro-oxidants depending on conditions and pro-oxidation might be the reason for activation of Nrf2.	Alkaloids	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164	
30009889-5	2018	Some natural products including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a key protein in the antioxidant defense system of hepatocytes.	Alkaloids	60-69	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85	
23108405-0	2013	Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity.	Alkaloids	51-59	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22	
31322315-5	2019	Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2.	Alkaloids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116	
31322315-5	2019	Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2.	Alkaloids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	251-255	
29277460-12	2018	Additionally, these alkaloids promoted the translocation of Nrf2 from the cytoplasm to the nucleus and significantly increased ARE-luciferin activity in HepG2-C8 cells.	Alkaloids	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64