PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29438749-3 2018 In the present study, we found that the total alkaloids of D. crepidatum (TAD) can inhibit the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated macrophages and showed protective effects against LPS-induced acute lung injury (ALI) in mice through downregulating the TLR4-mediated MyD88/MAPK signaling pathway. Alkaloids 46-55 toll-like receptor 4 Mus musculus 286-290 31816576-0 2020 Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway. Alkaloids 0-20 toll-like receptor 4 Mus musculus 101-104 31816576-3 2020 In this study, the anti-inflammatory activitives and the potential mechanisms of five isosteroid alkaloids from F. Cirrhosae Bulbus were investigated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Alkaloids 86-106 toll-like receptor 4 Mus musculus 173-176 31816576-8 2020 These results demonstrated that isosteroid alkaloids from F. Cirrhosae Bulbus exert anti-inflammatory effects by down-regulating the level of inflammatory mediators via mediation of MAPK phosphorylation in LPS-induced RAW264.7 macrophages, thus could be candidates for the prevention and treatment of inflammatory diseases. Alkaloids 32-52 toll-like receptor 4 Mus musculus 206-209 31624922-0 2019 MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-kappaB signaling pathway-TLR4 dependent. Alkaloids 18-54 toll-like receptor 4 Mus musculus 155-159 29438749-7 2018 Taken together, indolizine-type alkaloids are the active components of D. crepidatum through downregulating the TLR4-mediated pathway, indicating some kind of therapy of TAD for ALI treatment. Alkaloids 32-41 toll-like receptor 4 Mus musculus 112-116 27287254-8 2016 The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK. Alkaloids 46-55 toll-like receptor 4 Mus musculus 198-202 21827366-2 2012 The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Alkaloids 13-22 toll-like receptor 4 Mus musculus 99-102 35623174-0 2022 Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-kappaB pathways in mice. Alkaloids 33-42 toll-like receptor 4 Mus musculus 132-136