PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31624922-0	2019	MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-kappaB signaling pathway-TLR4 dependent.	Alkaloids	18-54	toll-like receptor 4	Mus musculus	155-159	
31816576-0	2020	Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway.	Alkaloids	0-20	toll-like receptor 4	Mus musculus	101-104	
31816576-3	2020	In this study, the anti-inflammatory activitives and the potential mechanisms of five isosteroid alkaloids from F. Cirrhosae Bulbus were investigated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells.	Alkaloids	86-106	toll-like receptor 4	Mus musculus	173-176	
31816576-8	2020	These results demonstrated that isosteroid alkaloids from F. Cirrhosae Bulbus exert anti-inflammatory effects by down-regulating the level of inflammatory mediators via mediation of MAPK phosphorylation in LPS-induced RAW264.7 macrophages, thus could be candidates for the prevention and treatment of inflammatory diseases.	Alkaloids	32-52	toll-like receptor 4	Mus musculus	206-209	
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	toll-like receptor 4	Mus musculus	198-202	
29438749-3	2018	In the present study, we found that the total alkaloids of D. crepidatum (TAD) can inhibit the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated macrophages and showed protective effects against LPS-induced acute lung injury (ALI) in mice through downregulating the TLR4-mediated MyD88/MAPK signaling pathway.	Alkaloids	46-55	toll-like receptor 4	Mus musculus	286-290	
29438749-7	2018	Taken together, indolizine-type alkaloids are the active components of D. crepidatum through downregulating the TLR4-mediated pathway, indicating some kind of therapy of TAD for ALI treatment.	Alkaloids	32-41	toll-like receptor 4	Mus musculus	112-116	
35623174-0	2022	Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-kappaB pathways in mice.	Alkaloids	33-42	toll-like receptor 4	Mus musculus	132-136	
21827366-2	2012	The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.	Alkaloids	13-22	toll-like receptor 4	Mus musculus	99-102