PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7669753-0 1995 Effect of oxaloacetate and phosphorylation on ATP-citrate lyase activity. Oxaloacetic Acid 10-22 ATP citrate lyase Homo sapiens 46-63 12079877-1 2002 Mammals metabolize citrate to acetyl-CoA and oxaloacetate via the enzyme, ATP:citrate lyase. Oxaloacetic Acid 45-57 ATP citrate lyase Homo sapiens 74-91 18922930-2 2008 ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. Oxaloacetic Acid 125-137 ATP citrate lyase Homo sapiens 0-17 18922930-2 2008 ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. Oxaloacetic Acid 125-137 ATP citrate lyase Homo sapiens 19-23 15234082-5 2004 The primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. Oxaloacetic Acid 203-215 ATP citrate lyase Homo sapiens 124-141 7669753-1 1995 ATP-citrate lyase (CL) catalyzes the conversion of citrate and CoA to oxaloacetate (OA) and acetyl-CoA. Oxaloacetic Acid 70-82 ATP citrate lyase Homo sapiens 0-17 31411782-1 2019 ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP. Oxaloacetic Acid 64-76 ATP citrate lyase Homo sapiens 19-23 34205414-2 2021 Derived from mitochondrial synthesis and/or carboxylation of alpha-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate. Oxaloacetic Acid 137-149 ATP citrate lyase Homo sapiens 99-116 34122722-6 2021 CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators. Oxaloacetic Acid 185-197 ATP citrate lyase Homo sapiens 177-181 32849657-9 2020 MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types. Oxaloacetic Acid 149-161 ATP citrate lyase Homo sapiens 165-182 1675605-3 1991 Experiments performed with ATP citrate lyase and S-(3,4-dicarboxy-3-hydroxybutyl)-CoA are consistent with citryl-CoA but not with citryl-enzyme being the direct precursor of the products acetyl-CoA and oxaloacetate. Oxaloacetic Acid 202-214 ATP citrate lyase Homo sapiens 27-44 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Oxaloacetic Acid 123-135 ATP citrate lyase Homo sapiens 48-65 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Oxaloacetic Acid 123-135 ATP citrate lyase Homo sapiens 67-71 35264789-5 2022 Genetic co-essentiality mapping revealed a cluster of genes that is sufficient to compose a biochemical alternative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxaloacetate to complete this non-canonical TCA cycle. Oxaloacetic Acid 285-297 ATP citrate lyase Homo sapiens 228-245 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Oxaloacetic Acid 25-37 ATP citrate lyase Homo sapiens 0-4 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Oxaloacetic Acid 25-37 ATP citrate lyase Homo sapiens 166-170 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Oxaloacetic Acid 110-122 ATP citrate lyase Homo sapiens 0-4 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Oxaloacetic Acid 110-122 ATP citrate lyase Homo sapiens 166-170 30944472-1 2019 ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5. Oxaloacetic Acid 133-145 ATP citrate lyase Homo sapiens 0-17 30944472-1 2019 ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5. Oxaloacetic Acid 133-145 ATP citrate lyase Homo sapiens 19-23 30944476-1 2019 Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1. Oxaloacetic Acid 204-216 ATP citrate lyase Homo sapiens 35-52 30944476-1 2019 Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1. Oxaloacetic Acid 204-216 ATP citrate lyase Homo sapiens 54-58 26221340-2 2015 ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA. Oxaloacetic Acid 127-139 ATP citrate lyase Homo sapiens 0-17 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Oxaloacetic Acid 142-154 ATP citrate lyase Homo sapiens 0-17 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Oxaloacetic Acid 142-154 ATP citrate lyase Homo sapiens 19-23 26039450-2 2015 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Oxaloacetic Acid 95-107 ATP citrate lyase Homo sapiens 0-17 26039450-2 2015 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Oxaloacetic Acid 95-107 ATP citrate lyase Homo sapiens 19-22 26221340-2 2015 ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA. Oxaloacetic Acid 127-139 ATP citrate lyase Homo sapiens 19-23 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Oxaloacetic Acid 146-162 ATP citrate lyase Homo sapiens 0-17 25701462-1 2015 ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis. Oxaloacetic Acid 100-112 ATP citrate lyase Homo sapiens 0-17 25701462-1 2015 ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis. Oxaloacetic Acid 100-112 ATP citrate lyase Homo sapiens 19-23 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Oxaloacetic Acid 146-162 ATP citrate lyase Homo sapiens 19-23 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Oxaloacetic Acid 164-167 ATP citrate lyase Homo sapiens 0-17 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Oxaloacetic Acid 164-167 ATP citrate lyase Homo sapiens 19-23 22657152-1 2012 ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Oxaloacetic Acid 110-122 ATP citrate lyase Homo sapiens 0-17 25367309-1 2015 ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate. Oxaloacetic Acid 147-159 ATP citrate lyase Homo sapiens 0-17 25367309-1 2015 ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate. Oxaloacetic Acid 147-159 ATP citrate lyase Homo sapiens 19-23 22657152-1 2012 ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Oxaloacetic Acid 110-122 ATP citrate lyase Homo sapiens 19-22 21688263-1 2012 ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. Oxaloacetic Acid 88-100 ATP citrate lyase Homo sapiens 0-17 21688263-1 2012 ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. Oxaloacetic Acid 88-100 ATP citrate lyase Homo sapiens 19-22