PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28710924-4	2017	In order to understand the binding mechanism and structure-activity relationship of amidine-containing BACE1 inhibitors, molecular docking, and pharmacophore and 3D-QSAR studies have been carried out with 34 amidine derivatives to develop a pharmacophore model.	Amidines	208-215	beta-secretase 1	Homo sapiens	103-108	
34920170-2	2022	We faced this challenge with a 3,4,5,6-tetrahydropyridine-2-amine scaffold harboring an amidine, a key structural component of potential inhibitors of BACE1, the rate-limiting enzyme in the production of Abeta species that make up amyloid plaques in Alzheimer"s disease.	Amidines	88-95	beta-secretase 1	Homo sapiens	151-156	
31413800-2	2019	The intrinsic basic nature of low molecular weight, amidine-containing BACE 1 inhibitors makes them far from optimal as central nervous system drugs.	Amidines	52-59	beta-secretase 1	Homo sapiens	71-77	
28710924-4	2017	In order to understand the binding mechanism and structure-activity relationship of amidine-containing BACE1 inhibitors, molecular docking, and pharmacophore and 3D-QSAR studies have been carried out with 34 amidine derivatives to develop a pharmacophore model.	Amidines	84-91	beta-secretase 1	Homo sapiens	103-108	
30709653-3	2019	This review provides an overview of amidine-based BACE1 inhibitors between 2014 and 2018.	Amidines	36-43	beta-secretase 1	Homo sapiens	50-55	
29809004-1	2018	In previous studies, the introduction of electron withdrawing groups to 1,4-oxazine BACE1 inhibitors reduced the p Ka of the amidine group, resulting in compound 2 that showed excellent in vivo efficacy, lowering Abeta levels in brain and CSF.	Amidines	125-132	beta-secretase 1	Homo sapiens	84-89	
26140617-0	2015	A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.	Amidines	131-138	beta-secretase 1	Homo sapiens	145-150	
24704031-0	2014	The evolution of amidine-based brain penetrant BACE1 inhibitors.	Amidines	17-24	beta-secretase 1	Homo sapiens	47-52	
24704031-2	2014	This digest provides an overview of the amidine containing class of BACE1 inhibitors, of which multiple examples are now progressing through clinical trials.	Amidines	40-47	beta-secretase 1	Homo sapiens	68-73	
20043696-1	2010	A number of novel amidine containing heterocycles were designed to reproduce the unique interaction pattern, revealed by X-ray crystallography, between the BACE-1 catalytic diad and a weak NMR screening hit (3), with special attention paid to maintaining the appropriate basicity and limiting the number of H-bonding donors of these scaffolds.	Amidines	18-25	beta-secretase 1	Homo sapiens	156-162	
23683349-2	2013	Among the most common fragment hits were various amidine-containing molecules in which the amidine engaged in discrete H-bond donor-acceptor interaction with the BACE1 catalytic dyad.	Amidines	49-56	beta-secretase 1	Homo sapiens	162-167	
23683349-2	2013	Among the most common fragment hits were various amidine-containing molecules in which the amidine engaged in discrete H-bond donor-acceptor interaction with the BACE1 catalytic dyad.	Amidines	91-98	beta-secretase 1	Homo sapiens	162-167	
22998419-2	2012	We applied this approach to BACE1 inhibitors and designed four stereoisomeric cyclopropane compounds in which the ethylene linker of a known amidine-type inhibitor 2 was replaced with chiral cyclopropane rings.	Amidines	141-148	beta-secretase 1	Homo sapiens	28-33