PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	tumor necrosis factor	Homo sapiens	164-167	
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	tumor necrosis factor	Homo sapiens	204-207	
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	tumor necrosis factor	Homo sapiens	154-157	
32865318-0	2021	Isorhamnetin attenuates TNF-alpha-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-kappaB pathways.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	24-33	
32865318-11	2021	We found that isorhamnetin at 20 and 40 muM reduced the proliferation of BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	14-26	tumor necrosis factor	Homo sapiens	98-107	
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	155-164	
32865318-13	2021	Additionally, 10 muM isorhamnetin effectively reduced cell migration induced by TNF-alpha.	3-methylquercetin	21-33	tumor necrosis factor	Homo sapiens	80-89	
32865318-14	2021	Treatment with isorhamnetin inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and NF-kappaB pathways induced by TNF-alpha.	3-methylquercetin	15-27	tumor necrosis factor	Homo sapiens	135-144	
23391847-2	2013	In addition, the effects of persicarin and isorhamnetin on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-alpha (TNF-alpha) activated human umbilical vein endothelial cells (HUVECs).	3-methylquercetin	43-55	tumor necrosis factor	Homo sapiens	185-212	
26974691-5	2016	Isorhamnetin suppressed the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-12.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	39-72	
26045738-0	2015	Protective effects of isorhamnetin on apoptosis and inflammation in TNF-alpha-induced HUVECs injury.	3-methylquercetin	22-34	tumor necrosis factor	Homo sapiens	68-77	
26045738-6	2015	Pretreatment with isorhamnetin significantly reduced apoptosis in TNF-alpha-treated HUVECs.	3-methylquercetin	18-30	tumor necrosis factor	Homo sapiens	66-75	
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	tumor necrosis factor	Homo sapiens	48-57	
26045738-9	2015	So, isorhamnetin could suppress TNF-alpha-induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling in HUVECs, which might be one of the underlying mechanisms for treatment of coronary heart disease.	3-methylquercetin	4-16	tumor necrosis factor	Homo sapiens	32-41	
23391847-5	2013	In accordance with these anticoagulant activities, persicarin and isorhamnetin prolonged in vivo bleeding time and inhibited TNF-alpha induced PAI-1 production.	3-methylquercetin	66-78	tumor necrosis factor	Homo sapiens	125-134