PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24913217-4 2014 Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65. 3-methylquercetin 128-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 400-403 30483725-8 2019 The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus. 3-methylquercetin 58-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 302-305