PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33847382-4 2021 In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis. 3-methylquercetin 87-99 angiotensin converting enzyme 2 Homo sapiens 131-135 33847382-6 2021 Surface plasmon resonance assay proved the effect that isorhamnetin bound to the ACE2, and its affinity (KD value) was at the micromolar level, that was, 2.51 +- 0.68 muM. 3-methylquercetin 55-67 angiotensin converting enzyme 2 Homo sapiens 81-85 33847382-7 2021 Viral entry studies in vitro indicated that isorhamnetin inhibited SARS-CoV-2 spike pseudotyped virus entering ACE2h cells. 3-methylquercetin 44-56 angiotensin converting enzyme 2 Homo sapiens 111-115