PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24211276-4 2014 In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases. 3-methylquercetin 16-28 glutamate-cysteine ligase catalytic subunit Homo sapiens 251-276 24211276-4 2014 In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases. 3-methylquercetin 16-28 glutamate-cysteine ligase catalytic subunit Homo sapiens 278-281 24211276-7 2014 In addition, Nrf2 deficiency completely blocked the ability of isorhamnetin to induce HO-1 and GCL. 3-methylquercetin 63-75 glutamate-cysteine ligase catalytic subunit Homo sapiens 95-98