PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28322972-4	2017	Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3",5"-tetramethoxystilbene.	3-methylquercetin	120-132	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-86	
20696580-6	2010	In particular, methoxy types of flavones and flavonols such as chrysoeriol and isorhamnetin showed strong and selective inhibition against CYP1B1.	3-methylquercetin	79-91	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-145	
20696580-8	2010	The results suggested that chrysoeriol and isorhamnetin fit well into the active site of CYP1B1, but do not fit into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of these methoxyflavonoids and Ser-122 in CYP1A1 and Thr-124 in CYP1A2.	3-methylquercetin	43-55	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	89-95	
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	3-methylquercetin	109-121	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	146-152	
16226778-0	2006	Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.	3-methylquercetin	101-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	165-171	
16226778-9	2006	Overall, our novel findings indicate that G. biloba extract and the flavonol aglycones isorhamnetin, kaempferol, and quercetin preferentially inhibit the in vitro catalytic activity of human CYP1B1.	3-methylquercetin	87-99	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	191-197