PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28322972-4 2017 Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3",5"-tetramethoxystilbene. 3-methylquercetin 120-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 80-86 20696580-6 2010 In particular, methoxy types of flavones and flavonols such as chrysoeriol and isorhamnetin showed strong and selective inhibition against CYP1B1. 3-methylquercetin 79-91 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 139-145 20696580-8 2010 The results suggested that chrysoeriol and isorhamnetin fit well into the active site of CYP1B1, but do not fit into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of these methoxyflavonoids and Ser-122 in CYP1A1 and Thr-124 in CYP1A2. 3-methylquercetin 43-55 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 89-95 19794518-7 2009 In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene. 3-methylquercetin 109-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 146-152 16226778-0 2006 Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. 3-methylquercetin 101-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 165-171 16226778-9 2006 Overall, our novel findings indicate that G. biloba extract and the flavonol aglycones isorhamnetin, kaempferol, and quercetin preferentially inhibit the in vitro catalytic activity of human CYP1B1. 3-methylquercetin 87-99 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 191-197