PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35401244-8 2022 Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD. 3-methylquercetin 17-20 superoxide dismutase 2, mitochondrial Mus musculus 267-271