PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35401244-0 2022 Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD. 3-methylquercetin 0-12 kelch-like ECH-associated protein 1 Mus musculus 67-72 35401244-8 2022 Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD. 3-methylquercetin 17-20 kelch-like ECH-associated protein 1 Mus musculus 33-38 35401244-9 2022 In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway. 3-methylquercetin 40-43 kelch-like ECH-associated protein 1 Mus musculus 148-153