PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35401244-0 2022 Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD. 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66 35401244-8 2022 Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD. 3-methylquercetin 17-20 nuclear factor, erythroid derived 2, like 2 Mus musculus 93-134 35401244-8 2022 Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD. 3-methylquercetin 17-20 nuclear factor, erythroid derived 2, like 2 Mus musculus 136-140 35401244-9 2022 In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway. 3-methylquercetin 40-43 nuclear factor, erythroid derived 2, like 2 Mus musculus 143-147 35359022-8 2022 Additionally, isorhamnetin alleviated pathological changes of the liver tissue and suitably reversed NF-kB and Nrf2 immunoreactivity. 3-methylquercetin 14-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 111-115 33999329-0 2021 Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway. 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 183-187 33999329-9 2021 Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway. 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 87-91 33999329-11 2021 In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway. 3-methylquercetin 17-29 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 27161367-7 2016 Treatment of experimental stroke mice with isorhamnetin activated Nrf2/HO-1, suppressed iNOS/NO, and led to reduced formation of MDA and 3-NT in ipsilateral cortex. 3-methylquercetin 43-55 nuclear factor, erythroid derived 2, like 2 Mus musculus 66-70 20579867-5 2011 Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation. 3-methylquercetin 46-58 nuclear factor, erythroid derived 2, like 2 Mus musculus 175-179 27151496-6 2016 Isorhamnetin increased the nuclear translocation of Nrf2 in HSCs and increased antioxidant response element reporter gene activity. 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 52-56 26830132-0 2016 The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. 3-methylquercetin 29-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 106-110 26830132-3 2016 Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1). 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-157 26830132-3 2016 Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1). 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 159-163 26830132-5 2016 Moreover, the potential of isorhamnetin to mediate HO-1 induction and protect against H2O2-mediated growth inhibition was abrogated by transient transfection with Nrf2-specific small interfering RNA. 3-methylquercetin 27-39 nuclear factor, erythroid derived 2, like 2 Mus musculus 163-167 26830132-8 2016 Collectively, these results demonstrate that isorhamnetin augments the cellular antioxidant defense capacity by activating the Nrf2/HO-1 pathway involving the activation of the ERK pathway, thus protecting the C2C12 cells from H2O2-induced cytotoxicity. 3-methylquercetin 45-57 nuclear factor, erythroid derived 2, like 2 Mus musculus 127-131 35359022-0 2022 Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2. 3-methylquercetin 25-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 119-123 35359022-7 2022 Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2. 3-methylquercetin 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 265-269 35359022-9 2022 These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1. 3-methylquercetin 41-53 nuclear factor, erythroid derived 2, like 2 Mus musculus 209-213