PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29730426-7 2018 However, SIRT1 inhibition (Sirtinol) not only inhibited isorhamnetin-induced Nrf2/HO-1 upregulation and NOX-2/4 downregulation, but also alleviated its anti-apoptotic effects. 3-methylquercetin 56-68 NFE2 like bZIP transcription factor 2 Homo sapiens 77-81 29730426-6 2018 Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes. 3-methylquercetin 36-48 NFE2 like bZIP transcription factor 2 Homo sapiens 113-156 29730426-6 2018 Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes. 3-methylquercetin 36-48 NFE2 like bZIP transcription factor 2 Homo sapiens 158-162 29730426-8 2018 Taken together, these data indicate that isorhamnetin can exhibit positive effect on H/R-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes, which is partly attributable to the upregulation of SIRT1 and Nrf2/HO-1-mediated antioxidant signaling pathway. 3-methylquercetin 41-53 NFE2 like bZIP transcription factor 2 Homo sapiens 236-240 24211276-0 2014 Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. 3-methylquercetin 0-12 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 24211276-2 2014 However, the effects of isorhamnetin on Nrf2 activation and on the expressions of its downstream genes in hepatocytes have not been elucidated. 3-methylquercetin 24-36 NFE2 like bZIP transcription factor 2 Homo sapiens 40-44 24211276-3 2014 Here, we investigated whether isorhamnetin has the ability to activate Nrf2 and induce phase II antioxidant enzyme expression, and to determine the protective role of isorhamnetin on oxidative injury in hepatocytes. 3-methylquercetin 30-42 NFE2 like bZIP transcription factor 2 Homo sapiens 71-75 24211276-4 2014 In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases. 3-methylquercetin 16-28 NFE2 like bZIP transcription factor 2 Homo sapiens 68-72 24211276-5 2014 The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells. 3-methylquercetin 29-41 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 24211276-5 2014 The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells. 3-methylquercetin 29-41 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 24211276-5 2014 The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells. 3-methylquercetin 29-41 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 24211276-7 2014 In addition, Nrf2 deficiency completely blocked the ability of isorhamnetin to induce HO-1 and GCL. 3-methylquercetin 63-75 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 24211276-10 2014 Finally, we showed that Nrf2 deficiency blocked the ability of isorhamnetin to protect cells from injury induced by t-BHP. 3-methylquercetin 63-75 NFE2 like bZIP transcription factor 2 Homo sapiens 24-28 24211276-11 2014 Taken together, our results demonstrate that isorhamnetin is efficacious in protecting hepatocytes against oxidative stress by Nrf2 activation and in inducing the expressions of its downstream genes. 3-methylquercetin 45-57 NFE2 like bZIP transcription factor 2 Homo sapiens 127-131 34065697-0 2021 Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways. 3-methylquercetin 14-26 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 34065697-9 2021 Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes. 3-methylquercetin 27-39 NFE2 like bZIP transcription factor 2 Homo sapiens 105-148 34065697-9 2021 Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes. 3-methylquercetin 27-39 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 29704670-0 2018 Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. 3-methylquercetin 29-41 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 29704670-7 2018 The expression of Nrf2 and HO-1 were up-regulated by treatment of isorhamnetin. 3-methylquercetin 66-78 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 29704670-8 2018 Furthermore, knockdown of Nrf2 by siRNA reversed the anti-inflammatory effects of isorhamnetin. 3-methylquercetin 82-94 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 29704670-9 2018 In conclusion, these results suggested that isorhamnetin inhibited LPS-induced inflammation in HGFs by activating Nrf2 signaling pathway. 3-methylquercetin 44-56 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118