PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26502751-3	2015	The present study investigated the potential effects of the natural product, isorhamnetin on breast cancer, and examined the effects of isorhamnetin on the Akt/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK)/MAPK kinase (MEK) signaling cascades, which are two important signaling pathways for endocrine therapy resistance in breast cancer.	3-methylquercetin	136-148	mechanistic target of rapamycin kinase	Homo sapiens	160-189	
32039440-0	2020	Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway.	3-methylquercetin	0-12	mechanistic target of rapamycin kinase	Homo sapiens	176-180	
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	111-115	
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	117-123	
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	119-123	
26502751-5	2015	In addition, isorhamnetin was observed to inhibit the Akt/mTOR and the MEK/extracellular signal-regulated kinase phosphorylation cascades.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	58-62	
24398569-0	2014	Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway.	3-methylquercetin	0-12	mechanistic target of rapamycin kinase	Homo sapiens	70-74	
24398569-4	2014	It was demonstrated that isorhamnetin suppressed the proliferation of cells from all three cell lines, induced cell cycle arrest at the G2/M phase and suppressed cell proliferation by inhibiting the PI3K-Akt-mTOR pathway.	3-methylquercetin	25-37	mechanistic target of rapamycin kinase	Homo sapiens	208-212	
34269571-5	2021	The results show that ISO targeted PI3K and blocked the PI3K-AKT-mTOR signaling pathway, significantly inhibiting gastric cancer cell autophagy in a hypoxic environment, inhibiting cell proliferation, decreasing mitochondrial membrane potential, and promoting mitochondria-mediated apoptosis.	3-methylquercetin	22-25	mechanistic target of rapamycin kinase	Homo sapiens	65-69