PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2484686-1 1989 A previous study revealed that elevation of platelet cyclic GMP induced by a pharmacological activator of soluble guanylate cyclase, 3-morpholinosydnonimine (SIN-1), induced a major inhibition of Ca2+ influx caused by thrombin, as detected by monitoring the fluorescence of the Ca2+ indicator quin-2. linsidomine 133-156 coagulation factor II, thrombin Homo sapiens 218-226 1903680-2 1991 Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous and thrombin-stimulated release of endothelin in intact blood vessels. linsidomine 132-155 coagulation factor II, thrombin Homo sapiens 179-187 1903680-7 1991 The inhibitory effects of both 3-morpholinosydnonimine and nitroglycerin on the thrombin-stimulated release of endothelin were abolished in the presence of an inhibitor of soluble guanylate cyclase, methylene blue (10(-5) M). linsidomine 31-54 coagulation factor II, thrombin Homo sapiens 80-88 1707709-2 1990 Full inhibition of thrombin-induced platelet aggregation was elicited by the least maximal platelet inhibitory concentrations of nitric oxide (NO; 7 +/- 1 microM) or NO-donors which included sodium nitroprusside (NaNp; 80 +/- 13 microM) 3-morpholinosydnonimine (SIN-1; 3 +/- 0.1 microM) or endothelial cells (EC; 2.36 +/- 0.12 x 10(5) added 1 min before thrombin. linsidomine 237-260 coagulation factor II, thrombin Homo sapiens 19-27