PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17093075-7 2006 Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis. linsidomine 36-59 poly(ADP-ribose) polymerase 1 Homo sapiens 156-162 17093075-7 2006 Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis. linsidomine 36-59 poly(ADP-ribose) polymerase 1 Homo sapiens 164-194 15319433-4 2004 In the present study, exposure of rat pheochromocytoma (PC12) cells to the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1) induced apoptosis, which accompanied depletion of intracellular glutathione (GSH), c-Jun N-terminal kinase activation, mitochondrial membrane depolarization, the cleavage of poly(ADP-ribose)polymerase, and DNA fragmentation. linsidomine 95-132 poly(ADP-ribose) polymerase 1 Homo sapiens 315-341 16769901-3 2006 These agents were evaluated by using cortical neuron cultures in which PARP-1 activation was induced by the genotoxic agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) or 3-morpholinosydnonimine (SIN-1). linsidomine 172-195 poly(ADP-ribose) polymerase 1 Homo sapiens 71-77