PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15319433-4	2004	In the present study, exposure of rat pheochromocytoma (PC12) cells to the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1) induced apoptosis, which accompanied depletion of intracellular glutathione (GSH), c-Jun N-terminal kinase activation, mitochondrial membrane depolarization, the cleavage of poly(ADP-ribose)polymerase, and DNA fragmentation.	linsidomine	95-132	poly(ADP-ribose) polymerase 1	Homo sapiens	315-341	
16769901-3	2006	These agents were evaluated by using cortical neuron cultures in which PARP-1 activation was induced by the genotoxic agents N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) or 3-morpholinosydnonimine (SIN-1).	linsidomine	172-195	poly(ADP-ribose) polymerase 1	Homo sapiens	71-77	
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	linsidomine	36-59	poly(ADP-ribose) polymerase 1	Homo sapiens	156-162	
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	linsidomine	36-59	poly(ADP-ribose) polymerase 1	Homo sapiens	164-194