PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22656049-2 2012 Here, we compared two free-radical generators, 3-morpholinosydnonimine (SIN-1) and 2,2"-azo-bis(2-amidinopropane) hydrochloride (AAPH), by measuring the thiol oxidation kinetics of various thiols. linsidomine 47-70 MAPK associated protein 1 Homo sapiens 72-77 22514319-1 2012 Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO-) donor]; ONOO- can be produced from nitric oxide and reactive oxygen species during neurodegeneration. linsidomine 75-98 MAPK associated protein 1 Homo sapiens 100-105 22354542-8 2012 A disulfide bond between Cys6 and Cys113 was identified in 3-morpholinosydnonimine hydrochloride (SIN-1)-treated SR monomer and dimer. linsidomine 59-96 MAPK associated protein 1 Homo sapiens 98-103 21676000-6 2011 Among the induced proteins, ferredoxin-NADP reductase (FNR) was selected to evaluate the effect of nitration on its activity after heat stress and in vitro conditions using 3-morpholinosydnonimine (SIN-1) (peroxynitrite donor) as the nitrating agent, the FNR activity being inhibited. linsidomine 173-196 MAPK associated protein 1 Homo sapiens 198-203 22848780-1 2012 3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 21945407-3 2012 The aim of our work was to study the response of human endothelial cells to 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, and to highlight the possible protective roles of Nrf2 or the UPR pathway in this response. linsidomine 76-99 MAPK associated protein 1 Homo sapiens 101-106 21297123-8 2011 Molsidomine tended to increase MAP duration by 20.7 +- 13.4 ms. Incubation of isolated atrial myocytes with NO donor 3-morpholino-sydnonimine (SIN-1) increased significantly l-type Ca(2+) current and [Ca(2+)](i) transients. linsidomine 117-141 MAPK associated protein 1 Homo sapiens 143-148 21598373-1 2011 Oxidation of dihydrorhodamine 123 (DHR) to rhodamine 123 (RH) by oxoperoxonitrite (ONOO(-)), formed through recombination of NO and O(2)( -) radicals resulting from thermal decomposition of 3-morpholinosydnonimine (SIN-1) in buffered aerated aqueous solution at pH 7.6, represents a kinetic model system of the reactivity of NO and O(2)( -) in biochemical systems. linsidomine 190-213 MAPK associated protein 1 Homo sapiens 215-220 21376033-3 2011 In a cell-free system, MHY336 exhibited a potent activity on scavenging of reactive oxygen species against 3-morpholinosydnonimine hydrochloride (SIN-1)-induced oxidative stress. linsidomine 107-144 MAPK associated protein 1 Homo sapiens 146-151 21663688-1 2011 BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). linsidomine 66-90 MAPK associated protein 1 Homo sapiens 92-97 21030671-3 2011 In this study ONOO(-) or 3-morpholinosydnonimine (Sin-1, a ONOO(-) donor) was applied to rat skinned muscle fibers to characterize the effects on contractile properties. linsidomine 25-48 MAPK associated protein 1 Homo sapiens 50-55 21239635-7 2011 In cultured human umbilical vein endothelial cells (HUVECs) exposed to elevated glucose (450 mg/dl) or ONOO derived from 3-morpholinosydnonimine (SIN-1), expression of COX-2 was increased and was prevented when endothelial cells were treated with FeTMPyP. linsidomine 121-144 MAPK associated protein 1 Homo sapiens 146-151 20463302-4 2010 Incubation of varphiX-174 plasmid DNA, with 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of DNA strand breaks in a concentration- and time-dependent manner. linsidomine 44-67 MAPK associated protein 1 Homo sapiens 69-74 20187709-3 2010 SIN-1 (3-morpholinosydnonimine) was used to elicit various degrees of nitroxidative stress in a reaction buffer and DAN (2,3-diaminonaphthalene) was used as a probe for N-nitrosation reaction. linsidomine 7-30 MAPK associated protein 1 Homo sapiens 0-5 19895807-4 2010 3-morpholinosydnonimine (SIN-1) co-generates NO and O(2)(-), yielding ONOO(-). linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 19913562-2 2010 MAIN METHODS: Cardiomyocytes, from neonatal mouse heart, in culture were treated with the NO donor 3-morpholinosydnonimine hydrochloride (SIN-1), which releases NO and peroxynitrite. linsidomine 99-136 MAPK associated protein 1 Homo sapiens 138-143 19768540-4 2010 Incubation of phiX-174 plasmid DNA with 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of both single- and double-stranded DNA breaks in a concentration- and time- dependent manner. linsidomine 40-63 MAPK associated protein 1 Homo sapiens 65-70 19704161-3 2009 Epoxide hydrolase activity was detected in human and murine endothelial cells as well in HEK293 cells and could be inhibited by either authentic peroxynitrite (ONOO(-)) or the ONOO(-) generator 3-morpholino-sydnonimine (SIN-1). linsidomine 194-218 MAPK associated protein 1 Homo sapiens 220-225 20823587-4 2010 Metabolic labeling experiments revealed that the amount of sulfated 17beta-estradiol or 4-methoxyestradiol decreased dramatically in MCF-10A mammary epithelial cells incubated in the presence of 3-morpholinosydnonimine (SIN-1) or diethylenetriamine NONOate (DETA NONOate), two nitric oxide donors commonly used to simulate nitrative stress conditions. linsidomine 195-218 MAPK associated protein 1 Homo sapiens 220-225 21048309-3 2010 In this study, geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. linsidomine 123-160 MAPK associated protein 1 Homo sapiens 162-167 19785994-3 2009 Peroxynitrite and its generator 3-morpholinosydnonimine (SIN-1) were used to cause DNA strand breaks in phiX-174 plasmid DNA. linsidomine 32-55 MAPK associated protein 1 Homo sapiens 57-62 19376194-4 2009 METHODS: Hen egg lysozyme was nitrated using varying amounts of either PN or the PN donor, 3-morpholinosydnonimine (SIN-1). linsidomine 91-114 MAPK associated protein 1 Homo sapiens 116-121 18835362-2 2009 We report herein some novel phenomena between hemin-H(2)O(2)-NO(2)(-) and 3-morpholinosydnonimine hydrochloride (SIN-1)-mediated oxidation and nitration reactions of glutamate dehydrogenase (GDH). linsidomine 74-111 MAPK associated protein 1 Homo sapiens 113-118 18841468-1 2009 The NO donor 3-Morpholinosydnonimine (SIN-1) releases NO in the presence of molecular oxygen. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 19583775-7 2009 MS analysis of the chimeric recombinant human ILT2-Fc protein after treatment with the peroxynitrite donor 3-(morpholinosydnonimine hydrochloride) (SIN-1) showed the nitration of Tyr35, Tyr76 and Tyr99, which are involved in human leucocyte antigen-G binding. linsidomine 107-146 MAPK associated protein 1 Homo sapiens 148-153 18774335-3 2009 Therefore, we have approached this issue by using an in vitro model to study the effect of an NO donor, 3-morpholinosydnonimine (SIN-1), on the proteome and infectivity of promastigotes of Leishmania infantum. linsidomine 104-127 MAPK associated protein 1 Homo sapiens 129-134 18662749-2 2008 We tested the hypothesis that elevated extracellular concentrations of ONOO(-), introduced by the donor 3-morpholinosydnonimine (SIN-1), induce reversible axonal conduction deficits in neurons of the guinea-pig spinal cord. linsidomine 104-127 MAPK associated protein 1 Homo sapiens 129-134 19104003-10 2009 Exogenous peroxynitrite and 3-morpholino sydnonimine (SIN-1) increased LOX-1 protein and mRNA expression. linsidomine 28-52 MAPK associated protein 1 Homo sapiens 54-59 19082545-4 2009 Incubation of phi X-174 plasmid DNA with the 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of both single- and double-stranded DNA breaks in a concentration- and time-dependent fashion. linsidomine 45-68 MAPK associated protein 1 Homo sapiens 70-75 17977674-4 2007 SIN-1(3-morpholino-sydnonimine), which leads to the simultaneous generation of superoxide anion and NO, and then forms the highly reactive species ONOO(-), induced a dose-dependent inhibition in amplitudes of transient potassium currents (I(A)) and delayed rectifier potassium currents (I(K)). linsidomine 6-30 MAPK associated protein 1 Homo sapiens 0-5 18287333-5 2008 Smooth muscle cells express this transporter constitutively and induction of the light chain component (xCT) by either diethyl maleate or 3-morpholino-sydnonimine (SIN-1) led to glutamate-inhibitable cystine uptake and an increased rate of cysteine release from cells. linsidomine 138-162 MAPK associated protein 1 Homo sapiens 164-169 17510982-2 2007 The aim of this study was to investigate the detrimental effects of the peroxynitrite donor SIN-1 (3-morpholinosydnonimine) on isolated brain mitochondria and to screen penicillamine, a stoichiometric (1:1) peroxynitrite-scavenging agent, and tempol, a catalytic scavenger of peroxynitrite-derived radicals, as antioxidant mitochondrial protectants. linsidomine 99-122 MAPK associated protein 1 Homo sapiens 92-97 17659433-1 2007 OBJECTIVE AND DESIGN: We investigated the intracellular signalling pathways by which nitric oxide (NO) donors: diethylamine/NO (DEA/NO) and 3-morpholinosydnonimine (SIN-1) regulate the functional response of human neutrophils to activating stimuli. linsidomine 140-163 MAPK associated protein 1 Homo sapiens 165-170 17227718-3 2007 Neonatal mouse cardiomyocytes in culture were treated with the NO donor SIN-1 (3-morpholinosydnonimine hydrochloride) for up to 20 h. RNA was collected, after either 2, 4 or 20 h, labeled and hybridized to cDNA microarray slides The concentration of SIN-1 was selected after concentration response studies of SIN-1 on cell viability, assessed by the MTT assay. linsidomine 79-116 MAPK associated protein 1 Homo sapiens 72-77 17111192-5 2007 We have verified this by measuring (14)CO(2) formation on incubation of 1-(14)C-PY with 3-morpholinosydnonimine (SIN-1). linsidomine 88-111 MAPK associated protein 1 Homo sapiens 113-118 16843826-8 2006 Neuronal NOS half-saturated with BH4 and the donor compound 3-morpholinosydnonimine (SIN-1) were used as enzymatic and nonenzymatic sources of NO/superoxide, respectively. linsidomine 60-83 MAPK associated protein 1 Homo sapiens 85-90 17093075-7 2006 Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis. linsidomine 36-59 MAPK associated protein 1 Homo sapiens 61-66 16955520-5 2006 In contrast, 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN-1 led to a considerably lowered viability of the virions. linsidomine 13-50 MAPK associated protein 1 Homo sapiens 52-57 16582935-16 2006 Similarly, both in control and CPA-treated CSM preparations, spontaneous Ca transients were accelerated by noradrenaline (NAd, 1 microM) and were suppressed by 3-morpholino-sydnonimine (SIN-1, 10 microM), a nitric oxide (NO) donor. linsidomine 160-184 MAPK associated protein 1 Homo sapiens 186-191 16504364-15 2006 In the presence of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) a dose-dependent significant genotoxic effect was obtained with 1-10mM myosmine after 4h incubation. linsidomine 43-66 MAPK associated protein 1 Homo sapiens 68-73 16533063-1 2006 Exposure of myosin subfragment 1 (S1) to 3-morpholinosydnonimine (SIN-1) produced a time-dependent inhibition of the F-actin-stimulated S1 Mg(2+)-ATPase activity, reaching 50% inhibition with 46.7 +/- 8.3 microM SIN-1 for 8.7 microM S1, that is, at a SIN-1/S1 molar ratio of approximately 5.5. linsidomine 41-64 MAPK associated protein 1 Homo sapiens 66-71 16480685-1 2006 Treatment of F-actin with the peroxynitrite-releasing agent 3-morpholinosydnonimine (SIN-1) produced a dose-dependent F-actin depolymerization. linsidomine 60-83 MAPK associated protein 1 Homo sapiens 85-90 16533063-1 2006 Exposure of myosin subfragment 1 (S1) to 3-morpholinosydnonimine (SIN-1) produced a time-dependent inhibition of the F-actin-stimulated S1 Mg(2+)-ATPase activity, reaching 50% inhibition with 46.7 +/- 8.3 microM SIN-1 for 8.7 microM S1, that is, at a SIN-1/S1 molar ratio of approximately 5.5. linsidomine 41-64 MAPK associated protein 1 Homo sapiens 212-217 15910705-9 2005 pre-treatment with 3-morpholino-sydnonimine-HCl (SIN-1, a non-enzymatic donor of NO) (50 and 500 mg i.a.) linsidomine 19-47 MAPK associated protein 1 Homo sapiens 49-54 16238488-2 2005 This was accomplished by administering a peroxynitrite donor 3-morpholinosydnonimine (SIN-1) into the gray matter of an uninjured rat spinal cord through a microdialysis fiber to generate ONOO at the SCI-elevated levels. linsidomine 61-84 MAPK associated protein 1 Homo sapiens 86-91 16159194-4 2005 The data show that zingerone can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1). linsidomine 125-162 MAPK associated protein 1 Homo sapiens 164-169 15890318-2 2005 In this study, the increase in dialysate DA induced by intrastriatal infusion of the NO-donor 3-morpholinosydnonimine (SIN-1, 1.0 mM for 180 min) was scarcely affected by Ca2+ omission. linsidomine 94-117 MAPK associated protein 1 Homo sapiens 119-124 16237680-5 2006 Cells coincubated with SIN-1(3-morpholinosydnonimine) or tat and gp120, together or separately, significantly increased oxidative stress on the SK-N-SH cells, as indicated by the increase in the levels of dichlorofluorescein (DCFH) fluorescence. linsidomine 29-52 MAPK associated protein 1 Homo sapiens 23-28 16330705-9 2005 The NO donor 3-morpholinosydnonimine (SIN-1) reproduced, in normal SR, several abnormal features seen in failing SR, such as defective interdomain interaction and abnormal Ca2+ leak. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 15807993-2 2005 Treatment with 3-morpholinosydnonimine (SIN-1) led to an increase in cellular ONOO(-) generation in comparison with non-treated cells. linsidomine 15-38 MAPK associated protein 1 Homo sapiens 40-45 16291239-3 2005 We have examined 3-morpholinosydnonimine (SIN-1)-induced apoptosis in control and metallothionein-overexpressing dopaminergic neurons, with a primary objective to determine the neuroprotective potential of metallothionein (MT) against peroxynitrite-induced neurodegeneration in PD. linsidomine 17-40 MAPK associated protein 1 Homo sapiens 42-47 15281495-3 2004 Thus, we hypothesized that exposure of plasma to the OONO- generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide, would result in a decrease in hemostatic function via diminished coagulation protein activity. linsidomine 74-97 MAPK associated protein 1 Homo sapiens 99-104 15458743-4 2004 METHODS: Confluent ECs were stimulated with 3-morpholinosydnonimine-HCl (SIN-1, a peroxynitrite generator) alone or combined with Mn(III) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP, a peroxynitrite scavenger) up to 4 hours. linsidomine 44-71 MAPK associated protein 1 Homo sapiens 73-78 15319433-4 2004 In the present study, exposure of rat pheochromocytoma (PC12) cells to the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1) induced apoptosis, which accompanied depletion of intracellular glutathione (GSH), c-Jun N-terminal kinase activation, mitochondrial membrane depolarization, the cleavage of poly(ADP-ribose)polymerase, and DNA fragmentation. linsidomine 95-132 MAPK associated protein 1 Homo sapiens 134-139 15384203-6 2004 3-morpholinosydnonimine (SIN-1), an ONOO(-) donor, at concentrations of 20-200 microM, induced a dose-dependent enhancement of STOCs in ASMCs and led to conspicuous increases in STOCs frequency and amplitude, which were prevented by prior exposure to low external Ca(2+) (200 nM), ryanodine (10 microM), or nifedipine (10 microM). linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 15357004-7 2004 3-Morpholinosydnonimine (SIN-1), which decomposes and yields peroxynitrite, induced GSTA2, which was not inhibited by PKC depletion, but slightly enhanced by PKC activation, suggesting that PKC promotes peroxynitrite formation for Nrf2-mediated GSTA2 induction. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 15082025-5 2004 Incubation of phiX-174 plasmid DNA with the peroxynitrite generator, 3-morpholinosydnonimine (SIN-1) led to the formation of both single- and double-stranded DNA breaks in a concentration- and time-dependent fashion. linsidomine 69-92 MAPK associated protein 1 Homo sapiens 94-99 15161993-8 2004 In a cell-free system, the use of linsidomine (SIN-1) makes it possible to investigate the behavior of LACL induced by peroxynitrite release, which was significantly reduced by Met I concentrations ranging from 1.25 to 10 microg/ml. linsidomine 34-45 MAPK associated protein 1 Homo sapiens 47-52 14767634-4 2004 Addition of 3-morpholinosydnonimine (SIN-1) differentially affected the MMC-induced cell death and GSH depletion concentration dependently with a maximal inhibitory effect at 150 microM. linsidomine 12-35 MAPK associated protein 1 Homo sapiens 37-42 15105207-4 2004 OONO(-) was generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide. linsidomine 27-50 MAPK associated protein 1 Homo sapiens 52-57 15129734-3 2004 The results indicate that the L-012-derived chemiluminescence induced by superoxide from hypoxanthine/xanthine oxidase (HX/XO) or by 3-morpholino sydnonimine (SIN-1)-derived peroxynitrite largely depends on the incubation time. linsidomine 133-157 MAPK associated protein 1 Homo sapiens 159-164 14704910-1 2004 PURPOSE: To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1). linsidomine 135-158 MAPK associated protein 1 Homo sapiens 160-165 14744603-4 2004 However, ipsilateral intra-articular pretreatment with L-arginine (a NO substrate), or 3-morpholino-sydnonimine-HCl (SIN-1, a non-enzymatic donor of NO), potentiated the antinociceptive effect induced by rofecoxib. linsidomine 87-115 MAPK associated protein 1 Homo sapiens 117-122 15622856-1 2004 The production of peroxynitrite during 3-morpholinosydnonimine (SIN-1) decomposition can be continuously monitored, with a sensitivity < or = 0.1 microM, from the kinetics of NADH fluorescence quenching in phosphate buffers, as well as in buffers commonly used with cell cultures, like Locke"s buffer or Dulbecco"s modified Eagle"s medium (DMEM-F12). linsidomine 39-62 MAPK associated protein 1 Homo sapiens 64-69 14695179-6 2003 Here we show that both authentic peroxynitrite and SIN-1 (3-morpholinosydnonimine hydrochloride), a molecule that decomposes into NO and to form peroxynitrite, can inhibit wild-type p53 function in malignant glioma cells. linsidomine 58-95 MAPK associated protein 1 Homo sapiens 51-56 14530262-7 2003 The NO donor 3-morpholinosydnonimine, HCl (SIN-1) and 8-bromo-guanosine 3",5"-cyclic monophosphate (8-Br-cGMP) functionally desensitized U46619-mediated calcium mobilization and inositol 1,4,5-trisphosphate generation by TP alpha whereas signaling by TP beta was unaffected by either agent. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 43-48 14565768-5 2003 Peroxynitrite from bolus injection or slow release from higher concentrations of 3-morpholinosydnonimine (SIN-1) reacted with the benzothiophenes and E(2) to give aromatic ring nitration, whereas peroxynitrite, produced from the slow decomposition of lower concentrations of SIN-1, was relatively unreactive toward E(2) and yielded oxidation and nitrosation products with raloxifene and its isomer. linsidomine 81-104 MAPK associated protein 1 Homo sapiens 106-111 14637181-6 2003 Stretch injury significantly enhanced sensitivity to 3-morpholinosydnonimine (SIN-1) while attenuating relaxation to calcimycin. linsidomine 53-76 MAPK associated protein 1 Homo sapiens 78-83 12846690-2 2003 PURPOSE: To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1). linsidomine 190-214 MAPK associated protein 1 Homo sapiens 216-221 12964815-3 2003 To test this hypothesis, in this study we addressed the effects of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) on human streptokinase-induced plasmin activity. linsidomine 91-114 MAPK associated protein 1 Homo sapiens 116-121 12889010-5 2003 At physiologic pH, the peroxynitrite donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) was used to nitrate 4-hydroxyphenylacetic acid (4-HPA) to form 4-hydroxy-3-nitrophenyl acetic acid (NHPA). linsidomine 43-83 MAPK associated protein 1 Homo sapiens 85-90 12898126-7 2003 Augmentation of NO production was achieved by intraportal injection of 0.2, 0.4, 0.6 and 0.8 g/kg L-arginine and the NO donor, 3-morpholinosydnonimine (SIN-1), was injected intraportally at 0.2, 0.4, 0.6 and 0.8 mg/kg. linsidomine 127-150 MAPK associated protein 1 Homo sapiens 152-157 12711636-7 2003 Intradermal administration of 3-morpholino-sydnonimine-hydrochloride (SIN-1) enhanced, while its subcutaneous administration inhibited, subcutaneous hypernociception induced by PGE(2). linsidomine 30-68 MAPK associated protein 1 Homo sapiens 70-75 12694379-1 2003 We investigated the role played by catecholamine-dependent pathways in modulating the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) following its intracerebroventricular (i.c.v.) linsidomine 125-149 MAPK associated protein 1 Homo sapiens 151-156 12619044-4 2003 In this study, iontophoresis of 3-morpholinosydnonimine hydrochloride (SIN 1), a nitric oxide donor, produced reproducible, current-dependent inhibition of glutamate-induced excitation in 12 of 15 striatal neurons, reaching its maximal inhibitory effect (76.2 +/- 5.6% below baseline) during the application of a 100 nA current. linsidomine 32-69 MAPK associated protein 1 Homo sapiens 71-76 12880480-0 2003 Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. linsidomine 27-50 MAPK associated protein 1 Homo sapiens 52-57 12880480-3 2003 We have examined 3-morpholinosydnonimine (SIN-1)-induced apoptosis in control and metallothionein-overexpressing dopaminergic neurons, with a primary objective to determine the neuroprotective potential of metallothionein against peroxynitrite-induced neurodegeneration in Parkinson"s disease. linsidomine 17-40 MAPK associated protein 1 Homo sapiens 42-47 12711621-5 2003 Endothelium-independent relaxation produced by the NO donor, 3-morpholino-sydnonimine (SIN-1) was not different between strains. linsidomine 61-85 MAPK associated protein 1 Homo sapiens 87-92 12675148-3 2003 3-Morpholinosydnonimine (SIN-1), an NO donor, stimulated ACh release by 50%-70% when infused into the hippocampus of wild type C57B16 mice. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 12459918-4 2003 Recombinant human IRP1 was purified from Escherichia coli as a [4Fe-4S] cluster-containing protein, and exposed to 3-morpholinosydnonimine (SIN-1), which was used either as a peroxynitrite donor or as an NO donor when added with an excess of superoxide dismutase (SOD). linsidomine 115-138 MAPK associated protein 1 Homo sapiens 140-145 12503084-1 2003 To determine whether peroxynitrite at the concentration and duration present after spinal cord injury induces protein oxidation and nitration in vivo, the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) was administered into the gray matter of the rat spinal cord for 5 hr. linsidomine 175-198 MAPK associated protein 1 Homo sapiens 200-205 12243770-7 2002 Here we report that ciclopirox, which is clinically used as an anti-fungal agent, completely prevents the increased death in glucose-deprived astrocytes exposed to 3-morpholinosydnonimine (SIN-1, a peroxynitrite-releasing reagent). linsidomine 164-187 MAPK associated protein 1 Homo sapiens 189-194 12358454-3 2002 The data obtained show that sinapic acid can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1). linsidomine 137-174 MAPK associated protein 1 Homo sapiens 176-181 12405381-1 2002 OBJECT: A nitric oxide (NO) donor that has been successfully used in the treatment of myocardial infarction, 3-morpholinosydnonimine (SIN-1), may be a potential neuroprotective agent. linsidomine 109-132 MAPK associated protein 1 Homo sapiens 134-139 12446173-8 2002 3-Morpholinosydnonimine (SIN-1), which decomposes and yields peroxynitrite, increased the rGSTA2 mRNA and protein levels in a dose-dependent manner. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 12121494-1 2002 We investigated the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) and up-regulate hypothalamic neurones following its intravenous (i.v.) linsidomine 59-83 MAPK associated protein 1 Homo sapiens 85-90 12095397-1 2002 The response of the human radial artery to a direct NO donor, linsidomine or 3-morpholino-sydnonimine (Sin 1), in the therapeutic management of peri-operative spasm may increase the patency rates of these grafts in the short, medium and long term. linsidomine 77-101 MAPK associated protein 1 Homo sapiens 103-108 11874235-4 2002 Incubation with 3-morpholinosydnonimine (SIN-1; 0.25-1 mM), an NO* and O2- donor that leads to PN release, also reduced both hOB proliferation and differentiation. linsidomine 16-39 MAPK associated protein 1 Homo sapiens 41-46 12033808-9 2002 PC and the individual oligomers were all strong inhibitors of 3-morpholinosydnonimine (SIN-1)-induced oxidation of LDL, with procyanidin B3 showing the highest antioxidant activity at 0.1 microg/mL. linsidomine 62-85 MAPK associated protein 1 Homo sapiens 87-92 12020693-7 2002 The inhibition by L-NAME was restored by 3-morpholinosydnonimine (SIN-1) and S-nitroso-N-acetyl-penicillamine, whereas the inhibition by ODQ was restored by dibutyryl cyclic GMP. linsidomine 41-64 MAPK associated protein 1 Homo sapiens 66-71 12072157-9 2002 SIN-1 (3-morpholinosydnonimine) produces peroxynitrite via generation of NO and O2-. linsidomine 7-30 MAPK associated protein 1 Homo sapiens 0-5 12020848-1 2002 The present study was undertaken to investigate the mechanisms involved in a nitric oxide donor [3-morpholino-sydnonimine (SIN-1)]-induced activation of hypothalamic-pituitary-adrenal axis in urethane- and alpha-chloralose-anesthetized rats. linsidomine 97-121 MAPK associated protein 1 Homo sapiens 123-128 12111254-10 2002 The nitric oxide (NO) donors S-nitroso- N-acetylpenicillamine (SNAP) and 3-morpholinosydnonimine (SIN-1) also inhibited NSC(Ca). linsidomine 73-96 MAPK associated protein 1 Homo sapiens 98-103 11952339-1 2002 SIN-1 (3-morpholinosydnonimine), the active metabolite of the vasodilator drug molsidomine, decomposes spontaneously in solution. linsidomine 7-30 MAPK associated protein 1 Homo sapiens 0-5 11417851-3 2001 Cells were pretreated with Danchunhwan and exposed to sodium nitroprusside (SNP), an NO donor, and 3-morpholinosydnonimine (SIN-1) which simultaneously generates NO and superoxide, thus possibly forming peroxynitrite. linsidomine 99-122 MAPK associated protein 1 Homo sapiens 124-129 11890743-6 2002 In intact RBC, the NO donors 3-morpholinosydnonimine (SIN-1) and peroxynitrite (ONOO(-)) significantly increased GAPD activity in the cytosol, glycolysis measured as lactate production, and energy charge levels. linsidomine 29-52 MAPK associated protein 1 Homo sapiens 54-59 11930241-8 2002 In addition, NO donor 3-morpholinosydnonimine (SIN-1) potentiated the effect of E(2). linsidomine 22-45 MAPK associated protein 1 Homo sapiens 47-52 11840442-7 2002 RESULTS: Treatment of chondrocytes with peroxynitrite (ONOO-), 3-morpholinosydnonimine (SIN-1), and sodium nitroprusside (SNP) resulted in apoptotic cell death at concentrations of 0.5 mM, 1.0 mM, and 0.5 mM, respectively. linsidomine 63-86 MAPK associated protein 1 Homo sapiens 88-93 11767407-3 2001 3-Morpholinosydnonimine hydrochloride (SIN-1) was used as a source of peroxynitrite. linsidomine 0-37 MAPK associated protein 1 Homo sapiens 39-44 11737550-1 2001 We previously showed that the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) released adrenocorticotropic hormone (ACTH) and upregulated transcripts for corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus (PVN) of the rat hypothalamus. linsidomine 95-119 MAPK associated protein 1 Homo sapiens 121-126 11564645-4 2001 In the present study, intrastriatal co-infusion of iron (II) (given as FeSO(4), 1 mM for 40 min) with the NO-donor and potential peroxynitrite generator 3-morpholinosydnonimine (SIN-1) (0.2, 0.5, 1.0 or 5.0 mM for 180 min), potentiated the SIN-1-induced increase in DA concentration in dialysates from the striatum of freely moving rats. linsidomine 153-176 MAPK associated protein 1 Homo sapiens 178-183 11410011-3 2001 Oxidation of pyrogallol red, liposomes, and microsomes initiated by peroxynitrite continuously produced by 3-morpholinosydnonimine (SIN-1, 2 mM) was time-dependent and enhanced by CO(2) (1 mM). linsidomine 107-130 MAPK associated protein 1 Homo sapiens 132-137 11313425-3 2001 In this study, 3-morpholinosydnonimine (SIN-1), an NO donor, was administered to Lewis rats on days 5-7 postimmunization, i.e., during the incipient phase of EAE. linsidomine 15-38 MAPK associated protein 1 Homo sapiens 40-45 11835396-2 2002 Exposure of the cells to 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, caused cytochrome c release from the mitochondria, caspase-3-like activation, and cell death. linsidomine 25-48 MAPK associated protein 1 Homo sapiens 50-55 11968012-2 2002 Vanadate prevented cell death induced by 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor; whereas SIN-1-induced cell death was not prevented by neither okadaic acid, an inhibitor of serine/threonine phosphatases 1 and 2A, nor cyclosporin A, an inhibitor of serine/threonine phosphatase 2B. linsidomine 41-64 MAPK associated protein 1 Homo sapiens 66-71 11711216-5 2001 Continuous infusion of the exogenous NO donor SIN-1 (3-morpholinosydnonimine) suppressed L-NNA induced increases of mean arterial blood pressure without effect on rCBF in comparison to baseline. linsidomine 53-76 MAPK associated protein 1 Homo sapiens 46-51 11489533-2 2001 Here, the effects produced by intravenous application of the nitric oxide synthase inhibitor L-N(G)-nitro arginine (L-NOARG, 100 microg/kg) and of the nitric oxide donor 3-morpholinosydnonimine hydrochloride (SIN-1, 500 microg/kg) on spontaneous CDPs were examined. linsidomine 170-207 MAPK associated protein 1 Homo sapiens 209-214 11487528-2 2001 Incubation of human umbilical vein endothelial cells (HUVEC) with SIN-1 (3-morpholinosydnonimine), a donor of NO, resulted in a rapid and dose-dependent increase in the expression of COX-2 as analysed by Western and Northern blotting. linsidomine 73-96 MAPK associated protein 1 Homo sapiens 66-71 11401858-1 2001 We studied how the nitric oxide (NO*) donor 3-morpholinosydnonimine (SIN-1) alters the response to beta-adrenergic stimulation in cardiac rat myocytes. linsidomine 44-67 MAPK associated protein 1 Homo sapiens 69-74 11438336-9 2001 Oxidants formed by mixing ascorbic acid with Fe(III)-EDTA, xanthine with xanthine oxidase, or by exposing sperm to the nitric oxide generator, SIN-1 (3-morpholinosydnonimine hydrochloride), were far less potent spermicidal agents. linsidomine 150-187 MAPK associated protein 1 Homo sapiens 143-148 11282353-2 2001 doses of the nitric oxide (NO)-donor 3-morpholinosydnonimine (SIN-1) (0.1-2.0 microg/10 microl) reduced, while higher doses had no effect (5 or 100 microg/10 microl) or increased (10 and 20 microg/10 microl) the mechanical allodynia induced by chronic ligature of the sciatic nerve in rats. linsidomine 37-60 MAPK associated protein 1 Homo sapiens 62-67 11274962-4 2001 Primary astrocytes isolated from the cerebral cortex of 1- to 2-day-old Sprague-Dawley rats were treated with morphine, naloxone, and 3-morpholinosydnonimine (SIN-1), a donor of peroxynitrite. linsidomine 134-157 MAPK associated protein 1 Homo sapiens 159-164 11504159-3 2001 The NO donor 3-morpholino-sydnonimine-hydrochloride (SIN-1) and 8-bromo-cGMP caused concentration-dependent decreases in phenylephrine-stimulated incorporation of 3H-leucine into cardiac myocytes. linsidomine 13-51 MAPK associated protein 1 Homo sapiens 53-58 11163539-2 2001 A peroxynitrite generator, 3-morpholinosydonimine (SIN-1), was found to induce the expression of three different growth arrest and DNA damage-inducible (GADD) mRNA, GADD34, GADD45, and GADD153, at the early phase during cell death in human neuroblastoma SH-SY5Y cells. linsidomine 27-49 MAPK associated protein 1 Homo sapiens 51-56 11069332-1 2000 We investigated the effect of propofol on endothelial cells subjected to the peroxynitrite (ONOO-) donor 3-morpholino sydnonimine (SIN-1). linsidomine 105-129 MAPK associated protein 1 Homo sapiens 131-136 11170241-2 2001 Previously, we showed that S-nitroso-N-acetylpenicillamine-amine (SNAP), which generates nitric oxide, and 3-morpholinosydnonimine (Sin-1), which generates equal molar concentrations of superoxide and nitric oxide resulting in peroxynitrite production, exhibited different levels of cytotoxicity to normal human hepatocytes in culture. linsidomine 107-130 MAPK associated protein 1 Homo sapiens 132-137 11134892-7 2001 The peroxynitrite generator, 3-morpholinosydnonimine (SIN-1), caused a concentration-dependent inhibition of fibroblast migration. linsidomine 29-52 MAPK associated protein 1 Homo sapiens 54-59 11145451-1 2000 The inhibitory effect of the nitric oxide (NO) donor S-nitroso-acetyl-penicillamine (SNAP) and the NO and O2- donor 3-morpholino-sydnonimine hydrochloride (SIN-1) was tested in a cell-free assay. linsidomine 116-154 MAPK associated protein 1 Homo sapiens 156-161 11011027-4 2000 In cultured endothelial cells from human umbilical veins (HUVECs), both S-nitroso-N-acetylpenicillamine and 3-morpholinosydnonimine (SIN-1) significantly reduced angiotensin-converting enzyme activity. linsidomine 108-131 MAPK associated protein 1 Homo sapiens 133-138 11003597-3 2000 Treatment of bovine aortic endothelial and smooth muscle cells with 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, resulted in transient depletion of glutathione followed by a prolonged increase beginning at 8-9 h. Concentration-dependent increases in glutathione of up to sixfold occurred 16-18 h after 0.05-2.5 mM SIN-1. linsidomine 68-91 MAPK associated protein 1 Homo sapiens 93-98 11009488-3 2000 Infusion of 3-morpholinosydnonimine (SIN-1, 10(-5) M), which may participate in S-nitrosylation (S-NO) via peroxynitrite formation, increased the rate of left ventricular pressure rise (+dP/dt; 19 +/- 4%, P < 0.001, n = 11) without increasing effluent cGMP or cAMP. linsidomine 12-35 MAPK associated protein 1 Homo sapiens 37-42 11003597-3 2000 Treatment of bovine aortic endothelial and smooth muscle cells with 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, resulted in transient depletion of glutathione followed by a prolonged increase beginning at 8-9 h. Concentration-dependent increases in glutathione of up to sixfold occurred 16-18 h after 0.05-2.5 mM SIN-1. linsidomine 68-91 MAPK associated protein 1 Homo sapiens 325-330 10991925-5 2000 In the presence of the NO donor, 3-morpholino-sydnonimine (SIN-1), pilocarpine no longer inhibited vagally induced bronchoconstriction. linsidomine 33-57 MAPK associated protein 1 Homo sapiens 59-64 10878602-7 2000 In glucose-deprived glial cells, MnTMPyP also completely blocked the augmented death and nitrotyrosine immunoreactivity induced by the ONOO(-)-producing reagent 3-morpholinosydnonimine (SIN-1). linsidomine 161-184 MAPK associated protein 1 Homo sapiens 186-191 10959486-1 2000 We have investigated the effect of 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, on carbachol-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in human neuroblastoma SH-SY5Y cells by means of single cell imaging of [Ca2+]i. linsidomine 35-58 MAPK associated protein 1 Homo sapiens 60-65 10781419-2 2000 [liberated by 3-morpholinosydnonimine (SIN-1) in the presence of superoxide dismutase], on cytosolic concentration of Ca(2+) ([Ca(2+)](i); single cells) and tone (intact strips) obtained from human main stem bronchi and canine trachealis. linsidomine 14-37 MAPK associated protein 1 Homo sapiens 39-44 10748119-4 2000 We studied the inhibitory effects of ascorbate on both NADH and dihydrorhodamine 123 (DHR) oxidation by peroxynitrite generated in situ from 3-morpholinosydnonimine N-ethylcarbamide (SIN-1). linsidomine 141-181 MAPK associated protein 1 Homo sapiens 183-188 10930123-4 2000 The cytotoxic effect of 3-morpholinosydnonimine (SIN-1), which is thought to form peroxynitrite (ONOO-) as a simultaneous O2- and NO generator, was completely blocked by SOD/CAT or Hb. linsidomine 24-47 MAPK associated protein 1 Homo sapiens 49-54 10800942-2 2000 The augmented death was mimicked by the peroxynitrite (ONOO )-producing reagent 3-morpholinosydnonimine (SIN-1). linsidomine 80-103 MAPK associated protein 1 Homo sapiens 105-110 10874594-4 2000 The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37 degrees C. These results indicate that the active oxidants in CSE are peroxynitrite-generating species like 3-morpholinosydnonimine (SIN-1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis. linsidomine 187-210 MAPK associated protein 1 Homo sapiens 212-217 10823274-1 2000 The 3-morpholinosydnonimine (SIN-1) generates both nitric oxide (NO) and superoxide anion (O2-). linsidomine 4-27 MAPK associated protein 1 Homo sapiens 29-34 10695661-9 2000 In contrast, 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, elicited a concentration-dependent reduction in NCA and MCA induced by MIP-1alpha. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 10516155-3 1999 3-Morpholinosydnonimine (SIN-1; 10(-4) M) and S-nitroso-N-acetylpenicillamine (SNAP; 10(-4) M) significantly inhibited NOS activity by 53% and 48%, respectively. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 10581309-3 1999 The negative effect, elicited by either 3-morpholino-sydnonimine (SIN-1) or S-nitroso-N-acetyl-penicillamine (SNAP), involved cyclic GMP (cGMP) production. linsidomine 40-64 MAPK associated protein 1 Homo sapiens 66-71 10661810-4 1999 The tissue injury produced by 3-morpholinosydnonimine (SIN-1), which is thought to form peroxynitrite (ONOO-) as a simultaneous O2- and NO generator, was blocked by SOD/CAT or Hb. linsidomine 30-53 MAPK associated protein 1 Homo sapiens 55-60 10444373-7 1999 The in vitro ovarian production of PGE and PGF(2alpha) was inhibited by L-NAME and stimulated by 3-morpho-linosydnonimine (SIN-1), a NO donor. linsidomine 97-121 MAPK associated protein 1 Homo sapiens 123-128 10478960-6 1999 S-nitroso-N-acetyl-DL-penicillamine (SNAP) and 3-morpholinosydnonimine (SIN-1) were used as NO donating reagents. linsidomine 47-70 MAPK associated protein 1 Homo sapiens 72-77 10924891-5 1999 Moreover, the antinociceptive effect of local nimesulide was potentiated by the coadministration of 3-morpholino-sydnonimine-HCl (SIN-1, a nitric oxide donor). linsidomine 100-128 MAPK associated protein 1 Homo sapiens 130-135 10493821-3 1999 To this end, we show that 3-morpholinosydnonimine hydrochloride (SIN-1), a compound capable of generating peroxynitrite, activates purified PGHS-1 and also stimulates PGE(2) production in arterial smooth muscle cells in the presence of exogenous arachidonic acid. linsidomine 26-63 MAPK associated protein 1 Homo sapiens 65-70 10460269-1 1999 We investigated the effect of the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on the release of adrenocorticotropin hormone (ACTH) and the neuronal response of hypothalamic neurons responsible for this release. linsidomine 99-123 MAPK associated protein 1 Homo sapiens 125-130 10436166-5 1999 Treatment of ECs with an NO donor, S-nitroso-N-acetylpenicillamine (SNAP) or 3-morpholinosydnonimine (SIN-1), inhibited this shear stress-induced Egr-1 expression. linsidomine 77-100 MAPK associated protein 1 Homo sapiens 102-107 10350003-1 1999 PURPOSE: Using an established cell culture model, the present study investigates whether linsidomine (SIN-1), a spontaneous donor of nitric oxide and active metabolite of the antianginal drug molsidomine, induces tolerance to its own cyclic GMP stimulatory action or shows a diminished response after tolerance induction with glyceryl trinitrate. linsidomine 89-100 MAPK associated protein 1 Homo sapiens 102-107 10391884-2 1999 Replacement of NAD with NADH in the presence of SIN-1 (3-morpholinosydnonimine) and dithiothreitol increased modification 25-fold. linsidomine 55-78 MAPK associated protein 1 Homo sapiens 48-53 10378451-3 1999 Two donor compounds, spermine NONOate, which can release authentic nitric oxide (NO), and 3-Morpholino-sydnonimine hydrochloride (SIN-1), which generates NO together with superoxide, possibly yielding peroxynitrite (ONOO-), were investigated in L5178Y mouse lymphoma cells for cytotoxic and genotoxic effects. linsidomine 90-128 MAPK associated protein 1 Homo sapiens 130-135 10463336-6 1999 Furthermore, A23187-induced endothelium-dependent relaxation was suppressed more strongly than endothelium-independent relaxation induced by SIN-1 (3-morpholino-sydnonimine), an NO donor, when aortic preparation was preconstricted with high KCl instead of agonistic stimulation (prostaglandin F2alpha). linsidomine 148-172 MAPK associated protein 1 Homo sapiens 141-146 10194176-4 1999 Accordingly, this study was designed to use 3-morpholinosydnonimine (SIN-1), a compound that releases peroxynitrite, to determine whether peroxynitrite could alter airway beta2-adrenoceptor (beta2-AR) function in anesthetized guinea pigs. linsidomine 44-67 MAPK associated protein 1 Homo sapiens 69-74 9729619-7 1998 Photolysis of the caged NO donor 3-morpholinosydnonimine (SIN-1) during agonist-induced [Ca2+]i oscillations inhibited Ca2+ release without affecting the rate of Ca2+ uptake and/or extrusion. linsidomine 33-56 MAPK associated protein 1 Homo sapiens 58-63 10085335-2 1999 A reduction in inhibition of the responses to cutaneous mechanical stimuli induced by PAG stimulation was seen in wide dynamic range (WDR) STT cells located in the deep layers of the dorsal horn when these neurons were sensitized during administration of a NO donor, 3-morpholinosydnonimine (SIN-1), into the dorsal horn by microdialysis. linsidomine 267-290 MAPK associated protein 1 Homo sapiens 292-297 10229110-3 1999 Incubation of myelin suspensions with the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) resulted in the formation of the lipid peroxidation product, malondialdehyde (MDA). linsidomine 62-85 MAPK associated protein 1 Homo sapiens 87-92 10398565-0 1999 Effect of antioxidants on induction time of luminol luminescence elicited by 3-morpholinosydnonimine (SIN-1). linsidomine 77-100 MAPK associated protein 1 Homo sapiens 102-107 10398565-1 1999 The reaction between luminol as a chemiluminescence probe and 3-morpholinosydnonimine (SIN-1) as a peroxynitrite donor was evaluated in order to determine the action of several antioxidants. linsidomine 62-85 MAPK associated protein 1 Homo sapiens 87-92 10353634-1 1999 Cultured porcine aortic endothelial cells (PAEC) were exposed to four concentrations (0.00 mM - 5.00 mM) of 3-Morpholino-sydnonimine-hydrochloride (SIN-1, a nitric oxide donor). linsidomine 108-146 MAPK associated protein 1 Homo sapiens 148-153 9926361-2 1998 Since peroxynitrite has a half-life of about 1 s, a drug known as linsidomine (SIN-1) is used as a peroxynitrite generator. linsidomine 66-77 MAPK associated protein 1 Homo sapiens 79-84 10401986-1 1999 We found that the exposure of human neuroblastoma SH-SY5Y cells to the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) induced tyrosine nitration of a 130-kDa protein, and prevented tyrosine phosphorylation of the 130-kDa protein. linsidomine 91-114 MAPK associated protein 1 Homo sapiens 116-121 10208290-6 1999 To raise the spinal NO level, the rats received the NO donor, 3-morpholino-sydnonimine (SIN-1, 10 and 100 microg/5 microl); to lower the NO level, the inhibitor of NO synthase, N-nitro-L-arginine methyl ester (L-NAME, 50 and 400 microg/5 microl), was administered. linsidomine 62-86 MAPK associated protein 1 Homo sapiens 88-93 10085334-3 1999 The NO level within the spinal dorsal horn was increased by microdialysis of a NO donor, 3-morpholinosydnonimine (SIN-1). linsidomine 89-112 MAPK associated protein 1 Homo sapiens 114-119 9781417-1 1998 Pharmacokinetic studies of molsidomine require a sensitive analytical method to allow the determination of concentrations of this compound and its active metabolite 3-morpholinosydnonimine (Sin-1) in the ng/ml range in plasma. linsidomine 165-188 MAPK associated protein 1 Homo sapiens 190-195 9655696-1 1998 We investigated the role of K+ channels and intracellular Ca2+ stores in the relaxations induced by the NO donor 3-morpholinosydnonimine (SIN-1) and 8-bromo-cGMP (8-BrcGMP), 8-(4-chlorophenylthio)-cGMP (pCPT-cGMP), and alpha, beta-methylene-ATP in isolated segments of rat ileum. linsidomine 113-136 MAPK associated protein 1 Homo sapiens 138-143 21781879-2 1998 3-Morpholinosydnonimine hydrochloride (SIN-1) produces NO and superoxide anion (O(2)( -)) which results in the formation of peroxynitrite (ONOO(-)). linsidomine 0-37 MAPK associated protein 1 Homo sapiens 39-44 9699549-8 1998 In contrast, 3-morpholino-sydnonimine (SIN-1), a sydnonimine analog and NO donor, increased the TER. linsidomine 13-37 MAPK associated protein 1 Homo sapiens 39-44 9544731-5 1998 NO donor, S-Nitroso-n-acetylpenicillamine (SNAP) or 3-morpholinosydnonimine (SIN-1) (0.1-1.0 mmol/l) dose-dependently reduced copper-induced oxidation of LDL as demonstrated by the inhibition of electrophoretic mobilities on agarose gels and the formation of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes. linsidomine 52-75 MAPK associated protein 1 Homo sapiens 77-82 9560296-2 1998 3-Morpholino-sydnonimine (SIN-1), a donor of both NO and O2(-)., leading to the production of ONOO-, dose-dependently inhibited growth of human keratinocytes without loss of viability. linsidomine 0-24 MAPK associated protein 1 Homo sapiens 26-31 9692786-13 1998 The NO donor 3-morpholino-sydnonimine (SIN-1) induced a concentration-dependent relaxation, which was unaffected by charybdotoxin plus apamin, but abolished by the selective soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ, 10 microM). linsidomine 13-37 MAPK associated protein 1 Homo sapiens 39-44 9582295-3 1998 In such studies 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a compound that simultaneously releases nitric oxide (.NO) and superoxide (O-2), is often used as a source for peroxynitrite. linsidomine 16-56 MAPK associated protein 1 Homo sapiens 58-63 9556559-1 1998 We report that exposure of aconitase to moderate concentrations of peroxynitrite, 3-morpholinosydnonimine (SIN-1; a superoxide- and nitric oxide-liberating substance), or hydrogen peroxide, inhibits the enzyme and enhances susceptibility to proteolytic digestion by the isolated 20 S proteasome. linsidomine 82-105 MAPK associated protein 1 Homo sapiens 107-112 9489619-9 1998 Similarly, 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells was inhibited by NS 2028 (IC50 30 nM). linsidomine 11-35 MAPK associated protein 1 Homo sapiens 37-42 9390110-4 1997 METHODS: We tested the vascular effects of nitroglycerin and linsidomine (SIN-1) in forearm resistance arteries (venous occlusion plethysmography) and hand veins (venous compliance technique) using a randomized, double-blind placebo-controlled regimen in 33 healthy subjects (age range, 22 to 38 years; mean age, 26 years) before and after 7 days of assignment to either 1 week of nitroglycerin administration (0.83 mg/hr) for induction of tolerance or placebo administration. linsidomine 61-72 MAPK associated protein 1 Homo sapiens 74-79 9444302-2 1997 The nitric oxide donor 3-morpholino-sydnonimine (SIN-1) (0.1 mmol/L) suppressed the beta-agonist isoproterenol- (1 mumol/L) stimulated increase in ICa-L and decreased the frequency and amplitude of spontaneous action potentials. linsidomine 23-47 MAPK associated protein 1 Homo sapiens 49-54 9463631-2 1997 METHODS: 3-Morpholinosydnonimine (SIN-1, 0.1 mM), an ONOO- donor, was administered alone or combined with superoxide dismutase (SOD, 300 U/ml) or glutathione (GSH, 1 mM) at the time of reperfusion. linsidomine 9-32 MAPK associated protein 1 Homo sapiens 34-39 9441836-2 1997 A 6-h pre-incubation with the nitric oxide (NO) donor linsidomine (SIN-1, 10-150 microM) protected endothelial cells in a concentration-dependent manner and increased viability by up to 59% of control. linsidomine 54-65 MAPK associated protein 1 Homo sapiens 67-72 9262367-4 1997 The NO-donor drugs molsidomine, 3-morpholinosydnone-imine (SIN-1), sodium nitroprusside (SNP) and glyceryl-trinitrate reduced the pulmonary hypertension in a dose-dependent fashion, whether admixed to the perfusate or inhaled as alveolar-accessible aerosol particles (aerosolization time 3-6 min), with an efficiency ranking of SNP > SIN-1 >> molsidomine and glyceryl-trinitrate. linsidomine 32-57 MAPK associated protein 1 Homo sapiens 59-64 9327781-2 1997 In this study, we investigated the effects of the nitric oxide donor 3-morpholino-sydnonimine (SIN-1) on platelet and neutrophil adhesion, and the vasomotor response, in a porcine model of angioplasty. linsidomine 69-93 MAPK associated protein 1 Homo sapiens 95-100 9291107-6 1997 In contrast, 3-[morpholinosydnonimine hydrochloride] (SIN-1), a peroxynitrite-forming compound, did not significantly inhibit either DNA synthesis or the EGFR tyrosine kinase activity. linsidomine 13-52 MAPK associated protein 1 Homo sapiens 54-59 9283566-4 1997 Cultures of human osteoblasts were exposed to 0.1, 1.0, and 10 microM of the nitric oxide releasing agent 3-morpholino sydnonimine (SIN-1) for 7 days. linsidomine 106-130 MAPK associated protein 1 Homo sapiens 132-137 9280288-5 1997 On the other hand, nitric oxide and superoxide generated concomitantly from 3-morpholinosydnonimine (SIN-1) did not induce appreciable hemolysis, while it converted hemoglobin to methemoglobin extensively. linsidomine 76-99 MAPK associated protein 1 Homo sapiens 101-106 9262367-4 1997 The NO-donor drugs molsidomine, 3-morpholinosydnone-imine (SIN-1), sodium nitroprusside (SNP) and glyceryl-trinitrate reduced the pulmonary hypertension in a dose-dependent fashion, whether admixed to the perfusate or inhaled as alveolar-accessible aerosol particles (aerosolization time 3-6 min), with an efficiency ranking of SNP > SIN-1 >> molsidomine and glyceryl-trinitrate. linsidomine 32-57 MAPK associated protein 1 Homo sapiens 337-342 9145927-1 1997 This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on human neutrophil degranulation. linsidomine 103-127 MAPK associated protein 1 Homo sapiens 129-134 9441903-2 1997 A 6-h preincubation with linsidomine (SIN-1, 0.5 mM) protected endothelial cells from hydrogen peroxide-dependent cytotoxicity and increased the surviving endothelial cell fraction by 85%. linsidomine 25-36 MAPK associated protein 1 Homo sapiens 38-43 9288123-6 1997 METHODS: PMNs isolated from human volunteers were preincubated with the NO donor 3-morpholinosydnonimine hydrochloride (SIN-1; 10(-6) to 10(-2) mol/L), cGMP (10(-3) mol/L), or the cell-permeable cGMP analog dibutyryl-cGMP (10(-3) mol/L) for 10 minutes. linsidomine 81-118 MAPK associated protein 1 Homo sapiens 120-125 9215025-6 1997 The combined nitric oxide-superoxide donor, 3-morpholinosydnonimine (SIN-1), dose-dependently decreased lipopolysaccharide-mediated IL-8 accumulation (P < 0.01). linsidomine 44-67 MAPK associated protein 1 Homo sapiens 69-74 9250372-9 1997 The NO donor 3-morpholinosydnonimine hydrochloride (SIN-1) at 200 microM caused hyperpolarizations (10-15 mV) similar to the IJP mediator, attenuated the IJPs, and abolished mechanical activities. linsidomine 13-50 MAPK associated protein 1 Homo sapiens 52-57 9175727-1 1997 The nitric oxide (NO) donor SIN-1 (3-morpholinosydnonimine) induced a concentration-dependent inhibition of the secretory response to glucose. linsidomine 35-58 MAPK associated protein 1 Homo sapiens 28-33 9202724-1 1997 We have previously used the comet assay to demonstrate that the nitric oxide donor 3-morpholinosydnonimine (SIN-1) produces DNA damage in rat islets of Langerhans and in the SV40-transformed insulin-secreting hamster cell line, HIT-T15. linsidomine 83-106 MAPK associated protein 1 Homo sapiens 108-113 8902271-1 1996 Exposure of isolated calf thymus DNA and human skin epidermal keratinocytes to peroxynitrite or the peroxynitrite generator, 3-morpholinosydnonimine (SIN-1), led to extensive DNA base modification. linsidomine 125-148 MAPK associated protein 1 Homo sapiens 150-155 9144574-1 1997 The cytotoxic effects of 3-morpholinosydnonimine (Sin-1) and S-nitroso-N-acetylpenicillamine-amine (SNAP) on replicatively active human hepatocyte cells in culture was determined as a function of oxidant type. linsidomine 25-48 MAPK associated protein 1 Homo sapiens 50-55 9190765-4 1997 This resulted in clinical studies with the intracavernous injected nitric oxide-donor linsidomine (SIN 1) and the orally given phosphodiesterase-inhibitor sildenafil. linsidomine 86-97 MAPK associated protein 1 Homo sapiens 99-104 9034630-2 1996 The aim of this study is to establish the ability of the known NO donor 3-morpholinosydnonimine (SIN-1) to prevent the cyclosporin A-induced contraction by using rat isolated glomeruli and cultured glomerular mesangial cells. linsidomine 72-95 MAPK associated protein 1 Homo sapiens 97-102 9109387-1 1997 This study investigates whether nitric oxide (NO) release from linsidomine (SIN-1), the active metabolite of the antianginal drug molsidomine, is light sensitive. linsidomine 63-74 MAPK associated protein 1 Homo sapiens 76-81 9114976-3 1997 Tocored and NGT also were formed when gamma-TH was exposed to 3-morpholinosydnonimine (SIN-1), a compound that decomposes to form peroxynitrite. linsidomine 62-85 MAPK associated protein 1 Homo sapiens 87-92 8982501-2 1996 The NO donor 3-morpholino-sydnonimine (SIN-1; 0.01-10 microM) evoked concentration-dependent relaxation of rat isolated mesenteric arteries pre-constricted with phenylephrine (1-3 microM). linsidomine 13-37 MAPK associated protein 1 Homo sapiens 39-44 8951422-5 1996 In contrast, 3-morpholinosydnonimine (SIN-1), a compound that rapidly generates peroxynitrite (ONOO-) from the released NO and O2-, slightly stimulated the PMA-induced respiratory burst. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 9047077-5 1996 This IL-1 beta-mediated induction of ICAM-1 and VCAM-1 expression was significantly inhibited in the presence of a NO donor 3-morpholino-sydnonimine (SIN-1) in a dose-dependent manner. linsidomine 124-148 MAPK associated protein 1 Homo sapiens 150-155 8912669-4 1996 As .NO sources we used .NO gas and two .NO-donors, S-nitroso-N-acetyl-D,L-penicillamine and 3-morpholinosydno-nimine hydrochloride (SIN-1). linsidomine 92-130 MAPK associated protein 1 Homo sapiens 132-137 8806782-6 1996 SP-A was also nitrated to a large extent following exposure to 3-morpholinosydnonimine (SIN-1) or tetranitromethane at pH 8. linsidomine 63-86 MAPK associated protein 1 Homo sapiens 88-93 8719784-15 1995 The NO donor, 3-morpholinosydnonimine (SIN-1) relaxed rat tail arteries precontracted with phenylephrine (1 microM). linsidomine 14-37 MAPK associated protein 1 Homo sapiens 39-44 8764220-5 1996 By contrast, 3-morpholinosydnonimine (SIN-1), which generates ONOO- by releasing O2- and .NO essentially in a simultaneous manner, significantly inhibited signaling. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 8887971-3 1996 Similarly, unilateral micro-injections (50 nl) of another NO-donor, 3-morpholinosydnonimine (SIN-1, 20-40-100 mM), also induced apnea (5.1 +/- 2.4 sec; 8.7 +/- 4.3 sec; 26.3 +/- 6.4 sec, respectively; n = 6) and a decrease in arterial blood pressure (6.2 +/- 2.3 mmHg; 11.1 +/- 3.3 mmHg; 18.3 +/- 6.1 mmHg, respectively; n = 6). linsidomine 68-91 MAPK associated protein 1 Homo sapiens 93-98 8546706-1 1996 We evaluated the effects of two NO donors, sodium nitroprusside (SNP) and 3-morpholino-sydnonimine (SIN-1), characterized by alternative redox states, i.e. nitrosonium ion (NO+) and nitric oxide (NO.) linsidomine 74-98 MAPK associated protein 1 Homo sapiens 100-105 9200208-2 1996 The NO-donor, 3-morpholinosydnonimine (SIN-1), decreased the amplitude of evoked inhibitory postsynaptic currents (buccal ganglion) and potentiated that of evoked excitatory postsynaptic currents (abdominal ganglion). linsidomine 14-37 MAPK associated protein 1 Homo sapiens 39-44 9008325-4 1996 Increasing doses of the NO donor linsidomine (SIN-1) were added with and without prior blockade of the NO/cGMP pathway by methylene blue and protein kinase (PK) inhibitors Rp-8-pCPT-cGMPS and RP-8-CPT-cAMPS. linsidomine 33-44 MAPK associated protein 1 Homo sapiens 46-51 8862144-6 1996 On the other hand, the NO donor SIN-1 (3-morpholino-sydnonimine, 10 microM) accelerated the decline in [Ca2+]i and contraction. linsidomine 39-63 MAPK associated protein 1 Homo sapiens 32-37 8586470-2 1995 Thirty minutes incubation of HWP with 3-morpholino-sydonimine (SIN-1, 10 microM) at 37 degrees C resulted in a 4.6-fold increase of cyclic GMP in platelets, whereas in the extracellular medium the increase was 17.6-fold. linsidomine 38-61 MAPK associated protein 1 Homo sapiens 63-68 7639707-3 1995 In the present study, we show that 3-morpholino-sydnonimine (SIN-1) is much more efficient than sodium nitroprusside (SNP) in stimulating the covalent labelling of GAPDH from cultured striatal neurones in the presence of [adenylate-32P]NAD+ (877 +/- 110 and 266 +/- 33% increase in NAD(+)-labelling induced by maximally effective concentrations of SIN-1 and SNP respectively). linsidomine 35-59 MAPK associated protein 1 Homo sapiens 61-66 7673115-2 1995 3-Morpholinosydnonimine (SIN-1) is widely used to generate nitric oxide (NO(x).) linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 7639707-3 1995 In the present study, we show that 3-morpholino-sydnonimine (SIN-1) is much more efficient than sodium nitroprusside (SNP) in stimulating the covalent labelling of GAPDH from cultured striatal neurones in the presence of [adenylate-32P]NAD+ (877 +/- 110 and 266 +/- 33% increase in NAD(+)-labelling induced by maximally effective concentrations of SIN-1 and SNP respectively). linsidomine 35-59 MAPK associated protein 1 Homo sapiens 348-353 7582498-6 1995 The relaxation induced by the nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1) was not affected by omega-conotoxin MVIIC. linsidomine 55-79 MAPK associated protein 1 Homo sapiens 81-86 8682618-3 1995 S-nitroso-N-acetylpenicillamine (SNAP), which generates NO when placed in an aqueous solution, and 3-morpholinosydnonimine (SIN-1), which liberates NO and O2-, resulting in the formation of peroxynitrite, were used as NO donors. linsidomine 99-122 MAPK associated protein 1 Homo sapiens 124-129 7494138-7 1995 In the presence of ISO the CCh-induced inhibition of ICa(L) could be mimicked by the NO donor 3-morpholino-sydnonimine (SIN-1; 0.1 mM). linsidomine 94-118 MAPK associated protein 1 Homo sapiens 120-125 7543172-3 1995 The endothelium-dependent relaxation to acetylcholine (ACh 1 nM-10 microM) and substance P (30 nM) was considerably reduced, whereas the relaxing effect to the endothelium-independent nitric oxide donor linsidomine (SIN-1) (100 microM) was unchanged. linsidomine 203-214 MAPK associated protein 1 Homo sapiens 216-221 7535933-10 1995 However, bone resorption depends on precursor replication and on the activity of the mature cells, and we found that the NO donor 3-morpholinosydnonimine (SIN-1) (50 microM) profoundly depressed replication in the human preosteoclast line. linsidomine 130-153 MAPK associated protein 1 Homo sapiens 155-160 7860763-2 1995 Recently, we found that the NO-donor SIN-1 (3-morpholino-sydnonimine) exerts a dual regulation of ICa in frog ventricular myocytes via an accumulation of cGMP. linsidomine 44-68 MAPK associated protein 1 Homo sapiens 37-42 7717176-1 1995 The study shows that endothelial cells from human umbilical veins have a soluble guanylate cyclase which can be activated by sodium nitroprusside (SNP), SIN-1 (3-morpholinosydnonimine) and S35b (4-methyl-3-phenylsulfonylfuroxan). linsidomine 160-183 MAPK associated protein 1 Homo sapiens 153-158 8208056-1 1994 We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model. linsidomine 158-196 MAPK associated protein 1 Homo sapiens 198-203 7925440-7 1994 NO-generating, cGMP-elevating agents [e.g. 3-morpholinosydnonimine hydrochloride (SIN1) and sodium nitroprusside] stimulated VASP Ser157 phosphorylation and inhibited glycoprotein IIb-IIIa activation up to a maximal extent of 30-50%. linsidomine 43-80 MAPK associated protein 1 Homo sapiens 82-86 7943250-3 1994 The simultaneous generation of .NO and superoxide by 3-morpholinosydnonimine (SIN-1, 0.1-2 mM) resulted in oxidation of dihydrorhodamine, a marker of peroxynitrite production, and a dose-dependent decrease in the ability of SP-A to enhance lipid aggregation. linsidomine 53-76 MAPK associated protein 1 Homo sapiens 78-83 7921622-6 1994 The relaxation to acetylcholine was similar in WKY rats and atenolol-treated SHR and more pronounced than in untreated SHR, whereas the relaxation to the nitric oxide donor 3-morpholinosydnonimine (SIN-1) was comparable in all study groups. linsidomine 173-196 MAPK associated protein 1 Homo sapiens 198-203 8014203-1 1994 We studied whether delayed posttreatment with the nitric oxide donor 3-morpholinosydnonimine (SIN-1) is effective in reducing the size of the infarct produced by occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats (SHRs). linsidomine 69-92 MAPK associated protein 1 Homo sapiens 94-99 8182511-4 1994 Unlike the nitrovasodilators, nitroglycerin and nicorandil, the nitric oxide donor agents, 3-morpholinosydnonimine (SIN-1) and sodium nitroprusside, both produced enhanced stimulation of LDCL following zymosan at low concentrations of the agonist and inhibition at high concentrations of the agonist. linsidomine 91-114 MAPK associated protein 1 Homo sapiens 116-121 7832624-10 1994 Administration of Linsidomine (SIN-1) induced vasodilatation by direct relaxation of the smooth muscle in both groups. linsidomine 18-29 MAPK associated protein 1 Homo sapiens 31-36 7952568-5 1994 The adenylyl cyclase stimulant forskolin, the nitric oxide donor compound 3-morpholinosydnonimine (SIN-1), and the guanylyl cyclase stimulant sodium nitroprusside caused concentration-dependent relaxation of histamine-contracted airway smooth muscle. linsidomine 74-97 MAPK associated protein 1 Homo sapiens 99-104 7531005-1 1994 The effects of intracerebral perfusion of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) and the nitric oxide synthase inhibitor N-nitroarginine (NARG) on the extracellular concentrations of glutamate (GLU) and gamma-aminobutyric acid (GABA) in striatum and CA1 area of the hippocampus were studied. linsidomine 70-94 MAPK associated protein 1 Homo sapiens 96-101 7519410-6 1994 After L-NAME, intracarotid infusion of the NO donor 3-morpholinosydnonimine (SIN-1; n = 6) increased resting CBF and reestablished the CBF increase elicited by hypercapnia (P > 0.05 from before L-NAME). linsidomine 52-75 MAPK associated protein 1 Homo sapiens 77-82 7994624-0 1994 [Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion]. linsidomine 10-21 MAPK associated protein 1 Homo sapiens 23-28 7994624-3 1994 Intravenous injection of linsidomine (SIN 1) a patent coronary vasodilatator, gives more reliable results than conventional imaging at the 4th h, and compares favourably with the results obtained at the 24th h after reinjection of 201 Tl. linsidomine 25-36 MAPK associated protein 1 Homo sapiens 38-43 8294165-0 1993 Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency. linsidomine 20-31 MAPK associated protein 1 Homo sapiens 33-38 7509893-0 1993 Hemodynamics, tolerability, and pharmacokinetics of linsidomine (SIN-1) infusion during the acute phase of uncomplicated myocardial infarction. linsidomine 52-63 MAPK associated protein 1 Homo sapiens 65-70 7509893-5 1993 After baseline hemodynamic values (period A) were determined, linsidomine (SIN-1) was infused at a rate of 0.8 mg/h and subsequently adjusted to obtain a 10% decrease in MBP from its baseline value (period B). linsidomine 62-73 MAPK associated protein 1 Homo sapiens 75-80 8294165-1 1993 Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1). linsidomine 145-156 MAPK associated protein 1 Homo sapiens 158-163 7509050-4 1993 The NOl donor SIN-1 (3-morpholinosydnonimine N-ethylcarbamide), at concentrations which produced a much higher guanylate cyclase activation (i.e. NO. linsidomine 21-61 MAPK associated protein 1 Homo sapiens 14-19 8216333-4 1993 3-Morpholino-sydnonimine (SIN-1) enhanced IL-1 alpha-induced TNF synthesis to a maximum of 272% (mean of n = 5 donors), with 100% set as TNF production by stimulation with IL-1 alpha alone. linsidomine 0-24 MAPK associated protein 1 Homo sapiens 26-31 1777378-3 1991 The elimination half-life of the active metabolite, linsidomine (SIN-1) was also prolonged in cirrhotic patients (7.5 +/- 5.4 h vs 1.0 +/- 0.19 h, P less than 0.05). linsidomine 52-63 MAPK associated protein 1 Homo sapiens 65-70 8274060-1 1993 Linsidomine or SIN-1, a vasodilator of epicardial arteries, is the active metabolite of Molsidomine which is regularly used for intracoronary injection. linsidomine 0-11 MAPK associated protein 1 Homo sapiens 15-20 1456572-6 1992 The nitric oxide donor compound, 3-morpholinosydnonimine (SIN-1), was equipotent at relaxing the central and peripheral airways. linsidomine 33-56 MAPK associated protein 1 Homo sapiens 58-63 1334757-7 1992 The NO donor, 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1; 0.1-30 microM), and the cyclic GMP phosphodiesterase inhibitor, zaprinast (0.1-30 microM) both induced a concentration-dependent inhibition of the electrical field stimulation-induced vasoconstriction, while atrial natriuretic peptide (ANP; 100 nM) produced only a slight decrease of the vasoconstrictor response. linsidomine 14-54 MAPK associated protein 1 Homo sapiens 56-61 1324680-1 1992 3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. linsidomine 0-24 MAPK associated protein 1 Homo sapiens 26-31 1310595-3 1992 We have used 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a sydnonimine capable of generating both NO and superoxide simultaneously, to test this hypothesis. linsidomine 13-53 MAPK associated protein 1 Homo sapiens 55-60 7504139-1 1993 If the vasodilation of the epicardial coronary arteries caused by linsidomine (SIN-1), the active metabolite of molsidomine, is well established, few data are available concerning the effects of SIN-1 on the acetylcholine (ACh)-induced vasoconstriction of epicardial coronary arteries. linsidomine 66-77 MAPK associated protein 1 Homo sapiens 79-84 7504146-1 1993 This study compared the action of nitroglycerin (GTN) and linsidomine (SIN-1) on vessel tone and prostacyclin (PGI2) production of human umbilical arteries in vitro. linsidomine 58-69 MAPK associated protein 1 Homo sapiens 71-76 8416805-3 1993 Whereas auto-ADP-ribosylation of ADH was stimulated to a minor extent by the NO-liberating agent 3-morpholinosydnonimine (SIN-1), LDH was unaffected. linsidomine 97-120 MAPK associated protein 1 Homo sapiens 122-127 1327163-3 1992 or 3-morpholino-sydnonimine-hydrochloride (SIN-1, a compound that spontaneously forms NO . linsidomine 3-41 MAPK associated protein 1 Homo sapiens 43-48 1512218-1 1992 Nitric oxide and nitric oxide-generating agents like 3-morpholinosydnonimine (SIN-1) stimulate the mono-ADP-ribosylation of a cytosolic, 39-kDa protein in various tissues. linsidomine 53-76 MAPK associated protein 1 Homo sapiens 78-83 1322663-2 1992 Sodium nitroprusside (SNP) and SIN-1 (3-morpholinosydnonimine), which spontaneously release the free radical nitric oxide (NO), cause direct relaxation of blood vessels and inhibition of platelet aggregation by activating soluble guanylate cyclase. linsidomine 38-61 MAPK associated protein 1 Homo sapiens 31-36 1414692-0 1992 Effect of prostaglandin E2 and 3-morpholinosydnonimine (SIN-1) on arachidonic acid metabolism in fMLP-stimulated rat neutrophils and on thrombin-induced human platelet aggregation. linsidomine 31-54 MAPK associated protein 1 Homo sapiens 56-61 1314618-2 1992 3-Morpholino-sydnonimine (SIN-1) blocked both NMDA-induced currents and the associated increase in intracellular Ca2+. linsidomine 0-24 MAPK associated protein 1 Homo sapiens 26-31 2156106-1 1990 To find out whether 3-morpholino-sydnonimine (SIN 1), the active metabolite of molsidomine, exerts its antiaggregatory effects not only in vitro but also in vivo, we tested ex vivo aggregation before and after intravenous application of molsidomine in healthy volunteers. linsidomine 20-44 MAPK associated protein 1 Homo sapiens 46-51 2175809-10 1990 The peptide antagonists affected only minimally or not at all the production of cyclic GMP evoked by a donor of nitric oxide, SIN-1 (3-Morpholino-Sydnonimine). linsidomine 133-157 MAPK associated protein 1 Homo sapiens 126-131 2207507-16 1990 In contrast, the relaxations to the nitric oxide donor, 3-morpholinosydnonimine (SIN-1; the active metabolite of molsidomine), did not differ in the three age groups. linsidomine 56-79 MAPK associated protein 1 Homo sapiens 81-86 1697805-2 1990 Molsidomine and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) at 0.01-1 mM, inhibited lysosomal enzyme release from PMN stimulated by 30 nM formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP). linsidomine 33-56 MAPK associated protein 1 Homo sapiens 58-63 2542278-7 1989 3-Morpholinosydnonimine (commonly known as SIN-1) (20-1000 micrograms/ml), another compound that acts through the spontaneous formation of nitric oxide as does sodium nitroprusside, also stimulates ADP-ribosylation of the 39-kDa protein. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 43-48 33806920-1 2021 The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner. linsidomine 43-66 MAPK associated protein 1 Homo sapiens 68-73 29746990-8 2018 Lateral ventricular delivery of the NO donor 3-morpholinosydnonimine (SIN-1) reversed inhibitory GnRH and LH responses to FD in high-E rats, and normalized rPO Vglut2, anteroventral periventricular KiSS1, and dorsomedial hypothalamic RFRP-3 mRNA and/or protein profiles. linsidomine 45-68 MAPK associated protein 1 Homo sapiens 70-75 2484686-1 1989 A previous study revealed that elevation of platelet cyclic GMP induced by a pharmacological activator of soluble guanylate cyclase, 3-morpholinosydnonimine (SIN-1), induced a major inhibition of Ca2+ influx caused by thrombin, as detected by monitoring the fluorescence of the Ca2+ indicator quin-2. linsidomine 133-156 MAPK associated protein 1 Homo sapiens 158-163 30425239-1 2018 We show that 3-morpholinosydnonimine (SIN-1)-induced nitric oxide (NO) triggers the formation of SGs. linsidomine 13-36 MAPK associated protein 1 Homo sapiens 38-43 30116317-3 2018 Therefore, the aim of the present study was to detect altered expression of osteogenesis-related genes in hypertrophic chondrocytes, following treatment with 3-morpholinosydnonimine (SIN-1). linsidomine 158-181 MAPK associated protein 1 Homo sapiens 183-188 2565981-5 1989 NG pre-incubation of GC (in contrast to coronary strips) almost completely abolished the direct and thiol-independent stimulatory effect of 3-morpholinosydnonimine (SIN-1) down to 4.5 +/- 0.2%, whereas pre-incubation with other nitrovasodilators reduced the stimulatory response to SIN-1 to only 59 to 98%. linsidomine 140-163 MAPK associated protein 1 Homo sapiens 165-170 29956685-4 2018 For this, spermatozoa were incubated with and without (untreated control) 3-morpholinosydnonimine (SIN-1), in order to generate peroxynitrite. linsidomine 74-97 MAPK associated protein 1 Homo sapiens 99-104 30119244-0 2018 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 30119244-5 2018 Here, we demonstrate that oxidative stress, as induced through treatment with 3-morpholinosydnonimine (SIN-1), a spontaneous ROS/RNS generator, decreased the cell viability in hypertrophic chondrocytes in a dose- and time- dependent manner. linsidomine 78-101 MAPK associated protein 1 Homo sapiens 103-108 30023514-4 2017 3-Morpholinosydnonimine hydrochloride (SIN-1) is an FDA-approved drug for inhibiting platelet aggregation in CVD. linsidomine 0-37 MAPK associated protein 1 Homo sapiens 39-44 28086193-6 2017 Levels of carbonylated species increased as early as 15min upon treatment with the peroxynitrite donor, 3-morpholinosydnonimine (SIN-1), and decreased to values close to control after 16h. linsidomine 104-127 MAPK associated protein 1 Homo sapiens 129-134 26764324-7 2016 Platelet aggregation was induced by ADP in the presence of AGE up to a concentration of 6.25% (vol:vol) alone or in combination with 3-morpholinosydnonimine (Sin-1), a nitric oxide donor. linsidomine 133-156 MAPK associated protein 1 Homo sapiens 158-163 27487446-7 2016 For this purpose, spermatozoa from healthy donors were exposed in vitro to 3-morpholinosydnonimine (SIN-1), a compound which generates peroxynitrite. linsidomine 75-98 MAPK associated protein 1 Homo sapiens 100-105 26894599-6 2016 The outstanding selectivity of the present CL probe leads us to detect the exogenous release of ONOO(-) from 3-morpholinosydnonimine (SIN-1) in living cells. linsidomine 109-132 MAPK associated protein 1 Homo sapiens 134-139 26629950-3 2016 Using 3-morpholino sydnonimine (Sin-1), we created low fluxes of peroxynitrite in our reaction set-up to demonstrate that salicylaldehyde displays unique features in the detection of physiological fluxes of peroxynitrite, yielding detectable nitration but only minor dimerization products. linsidomine 6-30 MAPK associated protein 1 Homo sapiens 32-37 23929591-5 2014 The mutant also exhibited an increased susceptibility to the nitric oxide-generating compound S-nitroso-N-acetylpenicillamine (SNAP) and 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor. linsidomine 137-174 MAPK associated protein 1 Homo sapiens 176-181 25476852-5 2015 We found that incubation of purified recombinant Sirt6 protein with 3-morpholinosydnonimine (SIN-1; a peroxynitrite donor that generates nitric oxide and superoxide simultaneously) increased Sirt6 tyrosine nitration and decreased its intrinsic catalytic activity. linsidomine 68-91 MAPK associated protein 1 Homo sapiens 93-98 25175370-6 2014 Of note, pre-treatment with 3-morpholinosydnonimine hydrochloride (SIN-1), an inducer of HO-1 expression, markedly attenuated cilostazol-induced chondrocyte senescence, and thus, we examined whether HO-1 directly modulates chondrocyte senescence induced by cilostazol. linsidomine 28-65 MAPK associated protein 1 Homo sapiens 67-72 24639107-6 2014 Muscle cells were treated with hydrogen peroxide (H2O2) (500 muM) for 30 min or the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) (1 mM) for 90 min to induce oxidative stress. linsidomine 104-127 MAPK associated protein 1 Homo sapiens 129-134 25552582-7 2015 3-Morpholinosydnonimine (SIN-1) (a donor of peroxynitrite) induced nitration of Kir6.1 subunit but not SUR2B. linsidomine 0-23 MAPK associated protein 1 Homo sapiens 25-30 25425609-6 2015 To do this, human spermatozoa from healthy donors were exposed in vitro to 3-morpholinosydnonimine (SIN-1), a molecule that generates peroxynitrite. linsidomine 75-98 MAPK associated protein 1 Homo sapiens 100-105 24375019-2 2014 SIN-1(3-morpholino-sydnonimine), which can lead the simultaneous generation of superoxide anion and nitric oxide, and then form the highly reactive species ONOO(-), induced dose-dependent inhibition in amplitudes of both mEPSCs and sEPSCs. linsidomine 6-30 MAPK associated protein 1 Homo sapiens 0-5 23567270-6 2013 Purified, recombinant PGIS showed a half-maximal nitration by 10 muM 3-morpholino sydnonimine (Sin-1) which increased in the presence of bicarbonate, and was only marginally induced by freely diffusing NO2-radicals generated by a peroxidase/nitrite/hydrogen peroxide system. linsidomine 69-93 MAPK associated protein 1 Homo sapiens 95-100 24351819-8 2013 As a conclusion, we believe that using 3-morpholinosydnonimine hydrochloride (Sin-1) as a ROS inducer in the DCF assay is feasible only qualitatively. linsidomine 39-76 MAPK associated protein 1 Homo sapiens 78-83 23529546-5 2013 Incubation of phiX-174 plasmid DNA with the peroxynitrite generator 3-morpholinosydnonimine (SIN-1) led to the formation of both single- and double-stranded DNA breaks in a concentration-dependent manner. linsidomine 68-91 MAPK associated protein 1 Homo sapiens 93-98 22607494-2 2013 In this study, the effects of DETA-NONOate, a pure NO slow generator, and of SIN-1 (3-morpholinosydnonimine), a peroxynitrite producer, on the activities of respiratory pathways, enzymatic and non-enzymatic antioxidants have been investigated in isolated mitochondria from pea leaves. linsidomine 84-107 MAPK associated protein 1 Homo sapiens 77-82