PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19913562-2	2010	MAIN METHODS: Cardiomyocytes, from neonatal mouse heart, in culture were treated with the NO donor 3-morpholinosydnonimine hydrochloride (SIN-1), which releases NO and peroxynitrite.	linsidomine	99-136	MAPK associated protein 1	Homo sapiens	138-143	
19895807-4	2010	3-morpholinosydnonimine (SIN-1) co-generates NO and O(2)(-), yielding ONOO(-).	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
19768540-4	2010	Incubation of phiX-174 plasmid DNA with 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of both single- and double-stranded DNA breaks in a concentration- and time- dependent manner.	linsidomine	40-63	MAPK associated protein 1	Homo sapiens	65-70	
19785994-3	2009	Peroxynitrite and its generator 3-morpholinosydnonimine (SIN-1) were used to cause DNA strand breaks in phiX-174 plasmid DNA.	linsidomine	32-55	MAPK associated protein 1	Homo sapiens	57-62	
20823587-4	2010	Metabolic labeling experiments revealed that the amount of sulfated 17beta-estradiol or 4-methoxyestradiol decreased dramatically in MCF-10A mammary epithelial cells incubated in the presence of 3-morpholinosydnonimine (SIN-1) or diethylenetriamine NONOate (DETA NONOate), two nitric oxide donors commonly used to simulate nitrative stress conditions.	linsidomine	195-218	MAPK associated protein 1	Homo sapiens	220-225	
21048309-3	2010	In this study, geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons.	linsidomine	123-160	MAPK associated protein 1	Homo sapiens	162-167	
18835362-2	2009	We report herein some novel phenomena between hemin-H(2)O(2)-NO(2)(-) and 3-morpholinosydnonimine hydrochloride (SIN-1)-mediated oxidation and nitration reactions of glutamate dehydrogenase (GDH).	linsidomine	74-111	MAPK associated protein 1	Homo sapiens	113-118	
19376194-4	2009	METHODS: Hen egg lysozyme was nitrated using varying amounts of either PN or the PN donor, 3-morpholinosydnonimine (SIN-1).	linsidomine	91-114	MAPK associated protein 1	Homo sapiens	116-121	
19583775-7	2009	MS analysis of the chimeric recombinant human ILT2-Fc protein after treatment with the peroxynitrite donor 3-(morpholinosydnonimine hydrochloride) (SIN-1) showed the nitration of Tyr35, Tyr76 and Tyr99, which are involved in human leucocyte antigen-G binding.	linsidomine	107-146	MAPK associated protein 1	Homo sapiens	148-153	
19704161-3	2009	Epoxide hydrolase activity was detected in human and murine endothelial cells as well in HEK293 cells and could be inhibited by either authentic peroxynitrite (ONOO(-)) or the ONOO(-) generator 3-morpholino-sydnonimine (SIN-1).	linsidomine	194-218	MAPK associated protein 1	Homo sapiens	220-225	
18841468-1	2009	The NO donor 3-Morpholinosydnonimine (SIN-1) releases NO in the presence of molecular oxygen.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
18774335-3	2009	Therefore, we have approached this issue by using an in vitro model to study the effect of an NO donor, 3-morpholinosydnonimine (SIN-1), on the proteome and infectivity of promastigotes of Leishmania infantum.	linsidomine	104-127	MAPK associated protein 1	Homo sapiens	129-134	
18662749-2	2008	We tested the hypothesis that elevated extracellular concentrations of ONOO(-), introduced by the donor 3-morpholinosydnonimine (SIN-1), induce reversible axonal conduction deficits in neurons of the guinea-pig spinal cord.	linsidomine	104-127	MAPK associated protein 1	Homo sapiens	129-134	
19082545-4	2009	Incubation of phi X-174 plasmid DNA with the 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of both single- and double-stranded DNA breaks in a concentration- and time-dependent fashion.	linsidomine	45-68	MAPK associated protein 1	Homo sapiens	70-75	
19104003-10	2009	Exogenous peroxynitrite and 3-morpholino sydnonimine (SIN-1) increased LOX-1 protein and mRNA expression.	linsidomine	28-52	MAPK associated protein 1	Homo sapiens	54-59	
17111192-5	2007	We have verified this by measuring (14)CO(2) formation on incubation of 1-(14)C-PY with 3-morpholinosydnonimine (SIN-1).	linsidomine	88-111	MAPK associated protein 1	Homo sapiens	113-118	
18287333-5	2008	Smooth muscle cells express this transporter constitutively and induction of the light chain component (xCT) by either diethyl maleate or 3-morpholino-sydnonimine (SIN-1) led to glutamate-inhibitable cystine uptake and an increased rate of cysteine release from cells.	linsidomine	138-162	MAPK associated protein 1	Homo sapiens	164-169	
17977674-4	2007	SIN-1(3-morpholino-sydnonimine), which leads to the simultaneous generation of superoxide anion and NO, and then forms the highly reactive species ONOO(-), induced a dose-dependent inhibition in amplitudes of transient potassium currents (I(A)) and delayed rectifier potassium currents (I(K)).	linsidomine	6-30	MAPK associated protein 1	Homo sapiens	0-5	
17227718-3	2007	Neonatal mouse cardiomyocytes in culture were treated with the NO donor SIN-1 (3-morpholinosydnonimine hydrochloride) for up to 20 h. RNA was collected, after either 2, 4 or 20 h, labeled and hybridized to cDNA microarray slides The concentration of SIN-1 was selected after concentration response studies of SIN-1 on cell viability, assessed by the MTT assay.	linsidomine	79-116	MAPK associated protein 1	Homo sapiens	72-77	
17510982-2	2007	The aim of this study was to investigate the detrimental effects of the peroxynitrite donor SIN-1 (3-morpholinosydnonimine) on isolated brain mitochondria and to screen penicillamine, a stoichiometric (1:1) peroxynitrite-scavenging agent, and tempol, a catalytic scavenger of peroxynitrite-derived radicals, as antioxidant mitochondrial protectants.	linsidomine	99-122	MAPK associated protein 1	Homo sapiens	92-97	
17659433-1	2007	OBJECTIVE AND DESIGN: We investigated the intracellular signalling pathways by which nitric oxide (NO) donors: diethylamine/NO (DEA/NO) and 3-morpholinosydnonimine (SIN-1) regulate the functional response of human neutrophils to activating stimuli.	linsidomine	140-163	MAPK associated protein 1	Homo sapiens	165-170	
16843826-8	2006	Neuronal NOS half-saturated with BH4 and the donor compound 3-morpholinosydnonimine (SIN-1) were used as enzymatic and nonenzymatic sources of NO/superoxide, respectively.	linsidomine	60-83	MAPK associated protein 1	Homo sapiens	85-90	
16955520-5	2006	In contrast, 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN-1 led to a considerably lowered viability of the virions.	linsidomine	13-50	MAPK associated protein 1	Homo sapiens	52-57	
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	linsidomine	36-59	MAPK associated protein 1	Homo sapiens	61-66	
16582935-16	2006	Similarly, both in control and CPA-treated CSM preparations, spontaneous Ca transients were accelerated by noradrenaline (NAd, 1 microM) and were suppressed by 3-morpholino-sydnonimine (SIN-1, 10 microM), a nitric oxide (NO) donor.	linsidomine	160-184	MAPK associated protein 1	Homo sapiens	186-191	
16480685-1	2006	Treatment of F-actin with the peroxynitrite-releasing agent 3-morpholinosydnonimine (SIN-1) produced a dose-dependent F-actin depolymerization.	linsidomine	60-83	MAPK associated protein 1	Homo sapiens	85-90	
16504364-15	2006	In the presence of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) a dose-dependent significant genotoxic effect was obtained with 1-10mM myosmine after 4h incubation.	linsidomine	43-66	MAPK associated protein 1	Homo sapiens	68-73	
16330705-9	2005	The NO donor 3-morpholinosydnonimine (SIN-1) reproduced, in normal SR, several abnormal features seen in failing SR, such as defective interdomain interaction and abnormal Ca2+ leak.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
16237680-5	2006	Cells coincubated with SIN-1(3-morpholinosydnonimine) or tat and gp120, together or separately, significantly increased oxidative stress on the SK-N-SH cells, as indicated by the increase in the levels of dichlorofluorescein (DCFH) fluorescence.	linsidomine	29-52	MAPK associated protein 1	Homo sapiens	23-28	
16533063-1	2006	Exposure of myosin subfragment 1 (S1) to 3-morpholinosydnonimine (SIN-1) produced a time-dependent inhibition of the F-actin-stimulated S1 Mg(2+)-ATPase activity, reaching 50% inhibition with 46.7 +/- 8.3 microM SIN-1 for 8.7 microM S1, that is, at a SIN-1/S1 molar ratio of approximately 5.5.	linsidomine	41-64	MAPK associated protein 1	Homo sapiens	66-71	
16533063-1	2006	Exposure of myosin subfragment 1 (S1) to 3-morpholinosydnonimine (SIN-1) produced a time-dependent inhibition of the F-actin-stimulated S1 Mg(2+)-ATPase activity, reaching 50% inhibition with 46.7 +/- 8.3 microM SIN-1 for 8.7 microM S1, that is, at a SIN-1/S1 molar ratio of approximately 5.5.	linsidomine	41-64	MAPK associated protein 1	Homo sapiens	212-217	
15890318-2	2005	In this study, the increase in dialysate DA induced by intrastriatal infusion of the NO-donor 3-morpholinosydnonimine (SIN-1, 1.0 mM for 180 min) was scarcely affected by Ca2+ omission.	linsidomine	94-117	MAPK associated protein 1	Homo sapiens	119-124	
16159194-4	2005	The data show that zingerone can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1).	linsidomine	125-162	MAPK associated protein 1	Homo sapiens	164-169	
16238488-2	2005	This was accomplished by administering a peroxynitrite donor 3-morpholinosydnonimine (SIN-1) into the gray matter of an uninjured rat spinal cord through a microdialysis fiber to generate ONOO at the SCI-elevated levels.	linsidomine	61-84	MAPK associated protein 1	Homo sapiens	86-91	
15910705-9	2005	pre-treatment with 3-morpholino-sydnonimine-HCl (SIN-1, a non-enzymatic donor of NO) (50 and 500 mg i.a.)	linsidomine	19-47	MAPK associated protein 1	Homo sapiens	49-54	
15319433-4	2004	In the present study, exposure of rat pheochromocytoma (PC12) cells to the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1) induced apoptosis, which accompanied depletion of intracellular glutathione (GSH), c-Jun N-terminal kinase activation, mitochondrial membrane depolarization, the cleavage of poly(ADP-ribose)polymerase, and DNA fragmentation.	linsidomine	95-132	MAPK associated protein 1	Homo sapiens	134-139	
16291239-3	2005	We have examined 3-morpholinosydnonimine (SIN-1)-induced apoptosis in control and metallothionein-overexpressing dopaminergic neurons, with a primary objective to determine the neuroprotective potential of metallothionein (MT) against peroxynitrite-induced neurodegeneration in PD.	linsidomine	17-40	MAPK associated protein 1	Homo sapiens	42-47	
15807993-2	2005	Treatment with 3-morpholinosydnonimine (SIN-1) led to an increase in cellular ONOO(-) generation in comparison with non-treated cells.	linsidomine	15-38	MAPK associated protein 1	Homo sapiens	40-45	
15384203-6	2004	3-morpholinosydnonimine (SIN-1), an ONOO(-) donor, at concentrations of 20-200 microM, induced a dose-dependent enhancement of STOCs in ASMCs and led to conspicuous increases in STOCs frequency and amplitude, which were prevented by prior exposure to low external Ca(2+) (200 nM), ryanodine (10 microM), or nifedipine (10 microM).	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
15458743-4	2004	METHODS: Confluent ECs were stimulated with 3-morpholinosydnonimine-HCl (SIN-1, a peroxynitrite generator) alone or combined with Mn(III) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP, a peroxynitrite scavenger) up to 4 hours.	linsidomine	44-71	MAPK associated protein 1	Homo sapiens	73-78	
15161993-8	2004	In a cell-free system, the use of linsidomine (SIN-1) makes it possible to investigate the behavior of LACL induced by peroxynitrite release, which was significantly reduced by Met I concentrations ranging from 1.25 to 10 microg/ml.	linsidomine	34-45	MAPK associated protein 1	Homo sapiens	47-52	
15281495-3	2004	Thus, we hypothesized that exposure of plasma to the OONO- generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide, would result in a decrease in hemostatic function via diminished coagulation protein activity.	linsidomine	74-97	MAPK associated protein 1	Homo sapiens	99-104	
15357004-7	2004	3-Morpholinosydnonimine (SIN-1), which decomposes and yields peroxynitrite, induced GSTA2, which was not inhibited by PKC depletion, but slightly enhanced by PKC activation, suggesting that PKC promotes peroxynitrite formation for Nrf2-mediated GSTA2 induction.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
15082025-5	2004	Incubation of phiX-174 plasmid DNA with the peroxynitrite generator, 3-morpholinosydnonimine (SIN-1) led to the formation of both single- and double-stranded DNA breaks in a concentration- and time-dependent fashion.	linsidomine	69-92	MAPK associated protein 1	Homo sapiens	94-99	
14767634-4	2004	Addition of 3-morpholinosydnonimine (SIN-1) differentially affected the MMC-induced cell death and GSH depletion concentration dependently with a maximal inhibitory effect at 150 microM.	linsidomine	12-35	MAPK associated protein 1	Homo sapiens	37-42	
15129734-3	2004	The results indicate that the L-012-derived chemiluminescence induced by superoxide from hypoxanthine/xanthine oxidase (HX/XO) or by 3-morpholino sydnonimine (SIN-1)-derived peroxynitrite largely depends on the incubation time.	linsidomine	133-157	MAPK associated protein 1	Homo sapiens	159-164	
15105207-4	2004	OONO(-) was generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide.	linsidomine	27-50	MAPK associated protein 1	Homo sapiens	52-57	
15622856-1	2004	The production of peroxynitrite during 3-morpholinosydnonimine (SIN-1) decomposition can be continuously monitored, with a sensitivity < or = 0.1 microM, from the kinetics of NADH fluorescence quenching in phosphate buffers, as well as in buffers commonly used with cell cultures, like Locke"s buffer or Dulbecco"s modified Eagle"s medium (DMEM-F12).	linsidomine	39-62	MAPK associated protein 1	Homo sapiens	64-69	
14744603-4	2004	However, ipsilateral intra-articular pretreatment with L-arginine (a NO substrate), or 3-morpholino-sydnonimine-HCl (SIN-1, a non-enzymatic donor of NO), potentiated the antinociceptive effect induced by rofecoxib.	linsidomine	87-115	MAPK associated protein 1	Homo sapiens	117-122	
14704910-1	2004	PURPOSE: To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1).	linsidomine	135-158	MAPK associated protein 1	Homo sapiens	160-165	
14637181-6	2003	Stretch injury significantly enhanced sensitivity to 3-morpholinosydnonimine (SIN-1) while attenuating relaxation to calcimycin.	linsidomine	53-76	MAPK associated protein 1	Homo sapiens	78-83	
14695179-6	2003	Here we show that both authentic peroxynitrite and SIN-1 (3-morpholinosydnonimine hydrochloride), a molecule that decomposes into NO and to form peroxynitrite, can inhibit wild-type p53 function in malignant glioma cells.	linsidomine	58-95	MAPK associated protein 1	Homo sapiens	51-56	
14530262-7	2003	The NO donor 3-morpholinosydnonimine, HCl (SIN-1) and 8-bromo-guanosine 3",5"-cyclic monophosphate (8-Br-cGMP) functionally desensitized U46619-mediated calcium mobilization and inositol 1,4,5-trisphosphate generation by TP alpha whereas signaling by TP beta was unaffected by either agent.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	43-48	
12898126-7	2003	Augmentation of NO production was achieved by intraportal injection of 0.2, 0.4, 0.6 and 0.8 g/kg L-arginine and the NO donor, 3-morpholinosydnonimine (SIN-1), was injected intraportally at 0.2, 0.4, 0.6 and 0.8 mg/kg.	linsidomine	127-150	MAPK associated protein 1	Homo sapiens	152-157	
12964815-3	2003	To test this hypothesis, in this study we addressed the effects of the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) on human streptokinase-induced plasmin activity.	linsidomine	91-114	MAPK associated protein 1	Homo sapiens	116-121	
12889010-5	2003	At physiologic pH, the peroxynitrite donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) was used to nitrate 4-hydroxyphenylacetic acid (4-HPA) to form 4-hydroxy-3-nitrophenyl acetic acid (NHPA).	linsidomine	43-83	MAPK associated protein 1	Homo sapiens	85-90	
14565768-5	2003	Peroxynitrite from bolus injection or slow release from higher concentrations of 3-morpholinosydnonimine (SIN-1) reacted with the benzothiophenes and E(2) to give aromatic ring nitration, whereas peroxynitrite, produced from the slow decomposition of lower concentrations of SIN-1, was relatively unreactive toward E(2) and yielded oxidation and nitrosation products with raloxifene and its isomer.	linsidomine	81-104	MAPK associated protein 1	Homo sapiens	106-111	
12711621-5	2003	Endothelium-independent relaxation produced by the NO donor, 3-morpholino-sydnonimine (SIN-1) was not different between strains.	linsidomine	61-85	MAPK associated protein 1	Homo sapiens	87-92	
12846690-2	2003	PURPOSE: To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1).	linsidomine	190-214	MAPK associated protein 1	Homo sapiens	216-221	
12619044-4	2003	In this study, iontophoresis of 3-morpholinosydnonimine hydrochloride (SIN 1), a nitric oxide donor, produced reproducible, current-dependent inhibition of glutamate-induced excitation in 12 of 15 striatal neurons, reaching its maximal inhibitory effect (76.2 +/- 5.6% below baseline) during the application of a 100 nA current.	linsidomine	32-69	MAPK associated protein 1	Homo sapiens	71-76	
12880480-0	2003	Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons.	linsidomine	27-50	MAPK associated protein 1	Homo sapiens	52-57	
12880480-3	2003	We have examined 3-morpholinosydnonimine (SIN-1)-induced apoptosis in control and metallothionein-overexpressing dopaminergic neurons, with a primary objective to determine the neuroprotective potential of metallothionein against peroxynitrite-induced neurodegeneration in Parkinson"s disease.	linsidomine	17-40	MAPK associated protein 1	Homo sapiens	42-47	
12694379-1	2003	We investigated the role played by catecholamine-dependent pathways in modulating the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) following its intracerebroventricular (i.c.v.)	linsidomine	125-149	MAPK associated protein 1	Homo sapiens	151-156	
12711636-7	2003	Intradermal administration of 3-morpholino-sydnonimine-hydrochloride (SIN-1) enhanced, while its subcutaneous administration inhibited, subcutaneous hypernociception induced by PGE(2).	linsidomine	30-68	MAPK associated protein 1	Homo sapiens	70-75	
12243770-7	2002	Here we report that ciclopirox, which is clinically used as an anti-fungal agent, completely prevents the increased death in glucose-deprived astrocytes exposed to 3-morpholinosydnonimine (SIN-1, a peroxynitrite-releasing reagent).	linsidomine	164-187	MAPK associated protein 1	Homo sapiens	189-194	
12503084-1	2003	To determine whether peroxynitrite at the concentration and duration present after spinal cord injury induces protein oxidation and nitration in vivo, the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) was administered into the gray matter of the rat spinal cord for 5 hr.	linsidomine	175-198	MAPK associated protein 1	Homo sapiens	200-205	
12459918-4	2003	Recombinant human IRP1 was purified from Escherichia coli as a [4Fe-4S] cluster-containing protein, and exposed to 3-morpholinosydnonimine (SIN-1), which was used either as a peroxynitrite donor or as an NO donor when added with an excess of superoxide dismutase (SOD).	linsidomine	115-138	MAPK associated protein 1	Homo sapiens	140-145	
12358454-3	2002	The data obtained show that sinapic acid can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the peroxynitrite donor 3-morpholinosydnonimine hydrochloride (SIN-1).	linsidomine	137-174	MAPK associated protein 1	Homo sapiens	176-181	
12405381-1	2002	OBJECT: A nitric oxide (NO) donor that has been successfully used in the treatment of myocardial infarction, 3-morpholinosydnonimine (SIN-1), may be a potential neuroprotective agent.	linsidomine	109-132	MAPK associated protein 1	Homo sapiens	134-139	
12675148-3	2003	3-Morpholinosydnonimine (SIN-1), an NO donor, stimulated ACh release by 50%-70% when infused into the hippocampus of wild type C57B16 mice.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
12446173-8	2002	3-Morpholinosydnonimine (SIN-1), which decomposes and yields peroxynitrite, increased the rGSTA2 mRNA and protein levels in a dose-dependent manner.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
12121494-1	2002	We investigated the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) and up-regulate hypothalamic neurones following its intravenous (i.v.)	linsidomine	59-83	MAPK associated protein 1	Homo sapiens	85-90	
12095397-1	2002	The response of the human radial artery to a direct NO donor, linsidomine or 3-morpholino-sydnonimine (Sin 1), in the therapeutic management of peri-operative spasm may increase the patency rates of these grafts in the short, medium and long term.	linsidomine	77-101	MAPK associated protein 1	Homo sapiens	103-108	
12072157-9	2002	SIN-1 (3-morpholinosydnonimine) produces peroxynitrite via generation of NO and O2-.	linsidomine	7-30	MAPK associated protein 1	Homo sapiens	0-5	
12020848-1	2002	The present study was undertaken to investigate the mechanisms involved in a nitric oxide donor [3-morpholino-sydnonimine (SIN-1)]-induced activation of hypothalamic-pituitary-adrenal axis in urethane- and alpha-chloralose-anesthetized rats.	linsidomine	97-121	MAPK associated protein 1	Homo sapiens	123-128	
11874235-4	2002	Incubation with 3-morpholinosydnonimine (SIN-1; 0.25-1 mM), an NO* and O2- donor that leads to PN release, also reduced both hOB proliferation and differentiation.	linsidomine	16-39	MAPK associated protein 1	Homo sapiens	41-46	
12033808-9	2002	PC and the individual oligomers were all strong inhibitors of 3-morpholinosydnonimine (SIN-1)-induced oxidation of LDL, with procyanidin B3 showing the highest antioxidant activity at 0.1 microg/mL.	linsidomine	62-85	MAPK associated protein 1	Homo sapiens	87-92	
12111254-10	2002	The nitric oxide (NO) donors S-nitroso- N-acetylpenicillamine (SNAP) and 3-morpholinosydnonimine (SIN-1) also inhibited NSC(Ca).	linsidomine	73-96	MAPK associated protein 1	Homo sapiens	98-103	
12020693-7	2002	The inhibition by L-NAME was restored by 3-morpholinosydnonimine (SIN-1) and S-nitroso-N-acetyl-penicillamine, whereas the inhibition by ODQ was restored by dibutyryl cyclic GMP.	linsidomine	41-64	MAPK associated protein 1	Homo sapiens	66-71	
11952339-1	2002	SIN-1 (3-morpholinosydnonimine), the active metabolite of the vasodilator drug molsidomine, decomposes spontaneously in solution.	linsidomine	7-30	MAPK associated protein 1	Homo sapiens	0-5	
11930241-8	2002	In addition, NO donor 3-morpholinosydnonimine (SIN-1) potentiated the effect of E(2).	linsidomine	22-45	MAPK associated protein 1	Homo sapiens	47-52	
11890743-6	2002	In intact RBC, the NO donors 3-morpholinosydnonimine (SIN-1) and peroxynitrite (ONOO(-)) significantly increased GAPD activity in the cytosol, glycolysis measured as lactate production, and energy charge levels.	linsidomine	29-52	MAPK associated protein 1	Homo sapiens	54-59	
11840442-7	2002	RESULTS: Treatment of chondrocytes with peroxynitrite (ONOO-), 3-morpholinosydnonimine (SIN-1), and sodium nitroprusside (SNP) resulted in apoptotic cell death at concentrations of 0.5 mM, 1.0 mM, and 0.5 mM, respectively.	linsidomine	63-86	MAPK associated protein 1	Homo sapiens	88-93	
11711216-5	2001	Continuous infusion of the exogenous NO donor SIN-1 (3-morpholinosydnonimine) suppressed L-NNA induced increases of mean arterial blood pressure without effect on rCBF in comparison to baseline.	linsidomine	53-76	MAPK associated protein 1	Homo sapiens	46-51	
11835396-2	2002	Exposure of the cells to 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, caused cytochrome c release from the mitochondria, caspase-3-like activation, and cell death.	linsidomine	25-48	MAPK associated protein 1	Homo sapiens	50-55	
11968012-2	2002	Vanadate prevented cell death induced by 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor; whereas SIN-1-induced cell death was not prevented by neither okadaic acid, an inhibitor of serine/threonine phosphatases 1 and 2A, nor cyclosporin A, an inhibitor of serine/threonine phosphatase 2B.	linsidomine	41-64	MAPK associated protein 1	Homo sapiens	66-71	
11767407-3	2001	3-Morpholinosydnonimine hydrochloride (SIN-1) was used as a source of peroxynitrite.	linsidomine	0-37	MAPK associated protein 1	Homo sapiens	39-44	
11737550-1	2001	We previously showed that the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) released adrenocorticotropic hormone (ACTH) and upregulated transcripts for corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus (PVN) of the rat hypothalamus.	linsidomine	95-119	MAPK associated protein 1	Homo sapiens	121-126	
11487528-2	2001	Incubation of human umbilical vein endothelial cells (HUVEC) with SIN-1 (3-morpholinosydnonimine), a donor of NO, resulted in a rapid and dose-dependent increase in the expression of COX-2 as analysed by Western and Northern blotting.	linsidomine	73-96	MAPK associated protein 1	Homo sapiens	66-71	
11564645-4	2001	In the present study, intrastriatal co-infusion of iron (II) (given as FeSO(4), 1 mM for 40 min) with the NO-donor and potential peroxynitrite generator 3-morpholinosydnonimine (SIN-1) (0.2, 0.5, 1.0 or 5.0 mM for 180 min), potentiated the SIN-1-induced increase in DA concentration in dialysates from the striatum of freely moving rats.	linsidomine	153-176	MAPK associated protein 1	Homo sapiens	178-183	
11489533-2	2001	Here, the effects produced by intravenous application of the nitric oxide synthase inhibitor L-N(G)-nitro arginine (L-NOARG, 100 microg/kg) and of the nitric oxide donor 3-morpholinosydnonimine hydrochloride (SIN-1, 500 microg/kg) on spontaneous CDPs were examined.	linsidomine	170-207	MAPK associated protein 1	Homo sapiens	209-214	
11401858-1	2001	We studied how the nitric oxide (NO*) donor 3-morpholinosydnonimine (SIN-1) alters the response to beta-adrenergic stimulation in cardiac rat myocytes.	linsidomine	44-67	MAPK associated protein 1	Homo sapiens	69-74	
11438336-9	2001	Oxidants formed by mixing ascorbic acid with Fe(III)-EDTA, xanthine with xanthine oxidase, or by exposing sperm to the nitric oxide generator, SIN-1 (3-morpholinosydnonimine hydrochloride), were far less potent spermicidal agents.	linsidomine	150-187	MAPK associated protein 1	Homo sapiens	143-148	
11504159-3	2001	The NO donor 3-morpholino-sydnonimine-hydrochloride (SIN-1) and 8-bromo-cGMP caused concentration-dependent decreases in phenylephrine-stimulated incorporation of 3H-leucine into cardiac myocytes.	linsidomine	13-51	MAPK associated protein 1	Homo sapiens	53-58	
11282353-2	2001	doses of the nitric oxide (NO)-donor 3-morpholinosydnonimine (SIN-1) (0.1-2.0 microg/10 microl) reduced, while higher doses had no effect (5 or 100 microg/10 microl) or increased (10 and 20 microg/10 microl) the mechanical allodynia induced by chronic ligature of the sciatic nerve in rats.	linsidomine	37-60	MAPK associated protein 1	Homo sapiens	62-67	
11410011-3	2001	Oxidation of pyrogallol red, liposomes, and microsomes initiated by peroxynitrite continuously produced by 3-morpholinosydnonimine (SIN-1, 2 mM) was time-dependent and enhanced by CO(2) (1 mM).	linsidomine	107-130	MAPK associated protein 1	Homo sapiens	132-137	
11417851-3	2001	Cells were pretreated with Danchunhwan and exposed to sodium nitroprusside (SNP), an NO donor, and 3-morpholinosydnonimine (SIN-1) which simultaneously generates NO and superoxide, thus possibly forming peroxynitrite.	linsidomine	99-122	MAPK associated protein 1	Homo sapiens	124-129	
11313425-3	2001	In this study, 3-morpholinosydnonimine (SIN-1), an NO donor, was administered to Lewis rats on days 5-7 postimmunization, i.e., during the incipient phase of EAE.	linsidomine	15-38	MAPK associated protein 1	Homo sapiens	40-45	
11274962-4	2001	Primary astrocytes isolated from the cerebral cortex of 1- to 2-day-old Sprague-Dawley rats were treated with morphine, naloxone, and 3-morpholinosydnonimine (SIN-1), a donor of peroxynitrite.	linsidomine	134-157	MAPK associated protein 1	Homo sapiens	159-164	
11163539-2	2001	A peroxynitrite generator, 3-morpholinosydonimine (SIN-1), was found to induce the expression of three different growth arrest and DNA damage-inducible (GADD) mRNA, GADD34, GADD45, and GADD153, at the early phase during cell death in human neuroblastoma SH-SY5Y cells.	linsidomine	27-49	MAPK associated protein 1	Homo sapiens	51-56	
11009488-3	2000	Infusion of 3-morpholinosydnonimine (SIN-1, 10(-5) M), which may participate in S-nitrosylation (S-NO) via peroxynitrite formation, increased the rate of left ventricular pressure rise (+dP/dt; 19 +/- 4%, P < 0.001, n = 11) without increasing effluent cGMP or cAMP.	linsidomine	12-35	MAPK associated protein 1	Homo sapiens	37-42	
11134892-7	2001	The peroxynitrite generator, 3-morpholinosydnonimine (SIN-1), caused a concentration-dependent inhibition of fibroblast migration.	linsidomine	29-52	MAPK associated protein 1	Homo sapiens	54-59	
11069332-1	2000	We investigated the effect of propofol on endothelial cells subjected to the peroxynitrite (ONOO-) donor 3-morpholino sydnonimine (SIN-1).	linsidomine	105-129	MAPK associated protein 1	Homo sapiens	131-136	
11003597-3	2000	Treatment of bovine aortic endothelial and smooth muscle cells with 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, resulted in transient depletion of glutathione followed by a prolonged increase beginning at 8-9 h. Concentration-dependent increases in glutathione of up to sixfold occurred 16-18 h after 0.05-2.5 mM SIN-1.	linsidomine	68-91	MAPK associated protein 1	Homo sapiens	93-98	
11003597-3	2000	Treatment of bovine aortic endothelial and smooth muscle cells with 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, resulted in transient depletion of glutathione followed by a prolonged increase beginning at 8-9 h. Concentration-dependent increases in glutathione of up to sixfold occurred 16-18 h after 0.05-2.5 mM SIN-1.	linsidomine	68-91	MAPK associated protein 1	Homo sapiens	325-330	
11170241-2	2001	Previously, we showed that S-nitroso-N-acetylpenicillamine-amine (SNAP), which generates nitric oxide, and 3-morpholinosydnonimine (Sin-1), which generates equal molar concentrations of superoxide and nitric oxide resulting in peroxynitrite production, exhibited different levels of cytotoxicity to normal human hepatocytes in culture.	linsidomine	107-130	MAPK associated protein 1	Homo sapiens	132-137	
11145451-1	2000	The inhibitory effect of the nitric oxide (NO) donor S-nitroso-acetyl-penicillamine (SNAP) and the NO and O2- donor 3-morpholino-sydnonimine hydrochloride (SIN-1) was tested in a cell-free assay.	linsidomine	116-154	MAPK associated protein 1	Homo sapiens	156-161	
11011027-4	2000	In cultured endothelial cells from human umbilical veins (HUVECs), both S-nitroso-N-acetylpenicillamine and 3-morpholinosydnonimine (SIN-1) significantly reduced angiotensin-converting enzyme activity.	linsidomine	108-131	MAPK associated protein 1	Homo sapiens	133-138	
10748119-4	2000	We studied the inhibitory effects of ascorbate on both NADH and dihydrorhodamine 123 (DHR) oxidation by peroxynitrite generated in situ from 3-morpholinosydnonimine N-ethylcarbamide (SIN-1).	linsidomine	141-181	MAPK associated protein 1	Homo sapiens	183-188	
10991925-5	2000	In the presence of the NO donor, 3-morpholino-sydnonimine (SIN-1), pilocarpine no longer inhibited vagally induced bronchoconstriction.	linsidomine	33-57	MAPK associated protein 1	Homo sapiens	59-64	
10959486-1	2000	We have investigated the effect of 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, on carbachol-induced increase in intracellular Ca2+ concentration ([Ca2+]i) in human neuroblastoma SH-SY5Y cells by means of single cell imaging of [Ca2+]i.	linsidomine	35-58	MAPK associated protein 1	Homo sapiens	60-65	
10878602-7	2000	In glucose-deprived glial cells, MnTMPyP also completely blocked the augmented death and nitrotyrosine immunoreactivity induced by the ONOO(-)-producing reagent 3-morpholinosydnonimine (SIN-1).	linsidomine	161-184	MAPK associated protein 1	Homo sapiens	186-191	
10800942-2	2000	The augmented death was mimicked by the peroxynitrite (ONOO )-producing reagent 3-morpholinosydnonimine (SIN-1).	linsidomine	80-103	MAPK associated protein 1	Homo sapiens	105-110	
10930123-4	2000	The cytotoxic effect of 3-morpholinosydnonimine (SIN-1), which is thought to form peroxynitrite (ONOO-) as a simultaneous O2- and NO generator, was completely blocked by SOD/CAT or Hb.	linsidomine	24-47	MAPK associated protein 1	Homo sapiens	49-54	
10781419-2	2000	[liberated by 3-morpholinosydnonimine (SIN-1) in the presence of superoxide dismutase], on cytosolic concentration of Ca(2+) ([Ca(2+)](i); single cells) and tone (intact strips) obtained from human main stem bronchi and canine trachealis.	linsidomine	14-37	MAPK associated protein 1	Homo sapiens	39-44	
10661810-4	1999	The tissue injury produced by 3-morpholinosydnonimine (SIN-1), which is thought to form peroxynitrite (ONOO-) as a simultaneous O2- and NO generator, was blocked by SOD/CAT or Hb.	linsidomine	30-53	MAPK associated protein 1	Homo sapiens	55-60	
10823274-1	2000	The 3-morpholinosydnonimine (SIN-1) generates both nitric oxide (NO) and superoxide anion (O2-).	linsidomine	4-27	MAPK associated protein 1	Homo sapiens	29-34	
10695661-9	2000	In contrast, 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, elicited a concentration-dependent reduction in NCA and MCA induced by MIP-1alpha.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
10874594-4	2000	The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37 degrees C. These results indicate that the active oxidants in CSE are peroxynitrite-generating species like 3-morpholinosydnonimine (SIN-1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis.	linsidomine	187-210	MAPK associated protein 1	Homo sapiens	212-217	
10581309-3	1999	The negative effect, elicited by either 3-morpholino-sydnonimine (SIN-1) or S-nitroso-N-acetyl-penicillamine (SNAP), involved cyclic GMP (cGMP) production.	linsidomine	40-64	MAPK associated protein 1	Homo sapiens	66-71	
10924891-5	1999	Moreover, the antinociceptive effect of local nimesulide was potentiated by the coadministration of 3-morpholino-sydnonimine-HCl (SIN-1, a nitric oxide donor).	linsidomine	100-128	MAPK associated protein 1	Homo sapiens	130-135	
10516155-3	1999	3-Morpholinosydnonimine (SIN-1; 10(-4) M) and S-nitroso-N-acetylpenicillamine (SNAP; 10(-4) M) significantly inhibited NOS activity by 53% and 48%, respectively.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
10493821-3	1999	To this end, we show that 3-morpholinosydnonimine hydrochloride (SIN-1), a compound capable of generating peroxynitrite, activates purified PGHS-1 and also stimulates PGE(2) production in arterial smooth muscle cells in the presence of exogenous arachidonic acid.	linsidomine	26-63	MAPK associated protein 1	Homo sapiens	65-70	
10463336-6	1999	Furthermore, A23187-induced endothelium-dependent relaxation was suppressed more strongly than endothelium-independent relaxation induced by SIN-1 (3-morpholino-sydnonimine), an NO donor, when aortic preparation was preconstricted with high KCl instead of agonistic stimulation (prostaglandin F2alpha).	linsidomine	148-172	MAPK associated protein 1	Homo sapiens	141-146	
10478960-6	1999	S-nitroso-N-acetyl-DL-penicillamine (SNAP) and 3-morpholinosydnonimine (SIN-1) were used as NO donating reagents.	linsidomine	47-70	MAPK associated protein 1	Homo sapiens	72-77	
10436166-5	1999	Treatment of ECs with an NO donor, S-nitroso-N-acetylpenicillamine (SNAP) or 3-morpholinosydnonimine (SIN-1), inhibited this shear stress-induced Egr-1 expression.	linsidomine	77-100	MAPK associated protein 1	Homo sapiens	102-107	
10391884-2	1999	Replacement of NAD with NADH in the presence of SIN-1 (3-morpholinosydnonimine) and dithiothreitol increased modification 25-fold.	linsidomine	55-78	MAPK associated protein 1	Homo sapiens	48-53	
10460269-1	1999	We investigated the effect of the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on the release of adrenocorticotropin hormone (ACTH) and the neuronal response of hypothalamic neurons responsible for this release.	linsidomine	99-123	MAPK associated protein 1	Homo sapiens	125-130	
10444373-7	1999	The in vitro ovarian production of PGE and PGF(2alpha) was inhibited by L-NAME and stimulated by 3-morpho-linosydnonimine (SIN-1), a NO donor.	linsidomine	97-121	MAPK associated protein 1	Homo sapiens	123-128	
10378451-3	1999	Two donor compounds, spermine NONOate, which can release authentic nitric oxide (NO), and 3-Morpholino-sydnonimine hydrochloride (SIN-1), which generates NO together with superoxide, possibly yielding peroxynitrite (ONOO-), were investigated in L5178Y mouse lymphoma cells for cytotoxic and genotoxic effects.	linsidomine	90-128	MAPK associated protein 1	Homo sapiens	130-135	
10350003-1	1999	PURPOSE: Using an established cell culture model, the present study investigates whether linsidomine (SIN-1), a spontaneous donor of nitric oxide and active metabolite of the antianginal drug molsidomine, induces tolerance to its own cyclic GMP stimulatory action or shows a diminished response after tolerance induction with glyceryl trinitrate.	linsidomine	89-100	MAPK associated protein 1	Homo sapiens	102-107	
10194176-4	1999	Accordingly, this study was designed to use 3-morpholinosydnonimine (SIN-1), a compound that releases peroxynitrite, to determine whether peroxynitrite could alter airway beta2-adrenoceptor (beta2-AR) function in anesthetized guinea pigs.	linsidomine	44-67	MAPK associated protein 1	Homo sapiens	69-74	
10208290-6	1999	To raise the spinal NO level, the rats received the NO donor, 3-morpholino-sydnonimine (SIN-1, 10 and 100 microg/5 microl); to lower the NO level, the inhibitor of NO synthase, N-nitro-L-arginine methyl ester (L-NAME, 50 and 400 microg/5 microl), was administered.	linsidomine	62-86	MAPK associated protein 1	Homo sapiens	88-93	
10401986-1	1999	We found that the exposure of human neuroblastoma SH-SY5Y cells to the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) induced tyrosine nitration of a 130-kDa protein, and prevented tyrosine phosphorylation of the 130-kDa protein.	linsidomine	91-114	MAPK associated protein 1	Homo sapiens	116-121	
10085334-3	1999	The NO level within the spinal dorsal horn was increased by microdialysis of a NO donor, 3-morpholinosydnonimine (SIN-1).	linsidomine	89-112	MAPK associated protein 1	Homo sapiens	114-119	
10229110-3	1999	Incubation of myelin suspensions with the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) resulted in the formation of the lipid peroxidation product, malondialdehyde (MDA).	linsidomine	62-85	MAPK associated protein 1	Homo sapiens	87-92	
10085335-2	1999	A reduction in inhibition of the responses to cutaneous mechanical stimuli induced by PAG stimulation was seen in wide dynamic range (WDR) STT cells located in the deep layers of the dorsal horn when these neurons were sensitized during administration of a NO donor, 3-morpholinosydnonimine (SIN-1), into the dorsal horn by microdialysis.	linsidomine	267-290	MAPK associated protein 1	Homo sapiens	292-297	
10353634-1	1999	Cultured porcine aortic endothelial cells (PAEC) were exposed to four concentrations (0.00 mM - 5.00 mM) of 3-Morpholino-sydnonimine-hydrochloride (SIN-1, a nitric oxide donor).	linsidomine	108-146	MAPK associated protein 1	Homo sapiens	148-153	
10398565-0	1999	Effect of antioxidants on induction time of luminol luminescence elicited by 3-morpholinosydnonimine (SIN-1).	linsidomine	77-100	MAPK associated protein 1	Homo sapiens	102-107	
10398565-1	1999	The reaction between luminol as a chemiluminescence probe and 3-morpholinosydnonimine (SIN-1) as a peroxynitrite donor was evaluated in order to determine the action of several antioxidants.	linsidomine	62-85	MAPK associated protein 1	Homo sapiens	87-92	
9729619-7	1998	Photolysis of the caged NO donor 3-morpholinosydnonimine (SIN-1) during agonist-induced [Ca2+]i oscillations inhibited Ca2+ release without affecting the rate of Ca2+ uptake and/or extrusion.	linsidomine	33-56	MAPK associated protein 1	Homo sapiens	58-63	
9926361-2	1998	Since peroxynitrite has a half-life of about 1 s, a drug known as linsidomine (SIN-1) is used as a peroxynitrite generator.	linsidomine	66-77	MAPK associated protein 1	Homo sapiens	79-84	
9781417-1	1998	Pharmacokinetic studies of molsidomine require a sensitive analytical method to allow the determination of concentrations of this compound and its active metabolite 3-morpholinosydnonimine (Sin-1) in the ng/ml range in plasma.	linsidomine	165-188	MAPK associated protein 1	Homo sapiens	190-195	
9560296-2	1998	3-Morpholino-sydnonimine (SIN-1), a donor of both NO and O2(-)., leading to the production of ONOO-, dose-dependently inhibited growth of human keratinocytes without loss of viability.	linsidomine	0-24	MAPK associated protein 1	Homo sapiens	26-31	
9655696-1	1998	We investigated the role of K+ channels and intracellular Ca2+ stores in the relaxations induced by the NO donor 3-morpholinosydnonimine (SIN-1) and 8-bromo-cGMP (8-BrcGMP), 8-(4-chlorophenylthio)-cGMP (pCPT-cGMP), and alpha, beta-methylene-ATP in isolated segments of rat ileum.	linsidomine	113-136	MAPK associated protein 1	Homo sapiens	138-143	
9692786-13	1998	The NO donor 3-morpholino-sydnonimine (SIN-1) induced a concentration-dependent relaxation, which was unaffected by charybdotoxin plus apamin, but abolished by the selective soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ, 10 microM).	linsidomine	13-37	MAPK associated protein 1	Homo sapiens	39-44	
9582295-3	1998	In such studies 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a compound that simultaneously releases nitric oxide (.NO) and superoxide (O-2), is often used as a source for peroxynitrite.	linsidomine	16-56	MAPK associated protein 1	Homo sapiens	58-63	
21781879-2	1998	3-Morpholinosydnonimine hydrochloride (SIN-1) produces NO and superoxide anion (O(2)( -)) which results in the formation of peroxynitrite (ONOO(-)).	linsidomine	0-37	MAPK associated protein 1	Homo sapiens	39-44	
9699549-8	1998	In contrast, 3-morpholino-sydnonimine (SIN-1), a sydnonimine analog and NO donor, increased the TER.	linsidomine	13-37	MAPK associated protein 1	Homo sapiens	39-44	
9556559-1	1998	We report that exposure of aconitase to moderate concentrations of peroxynitrite, 3-morpholinosydnonimine (SIN-1; a superoxide- and nitric oxide-liberating substance), or hydrogen peroxide, inhibits the enzyme and enhances susceptibility to proteolytic digestion by the isolated 20 S proteasome.	linsidomine	82-105	MAPK associated protein 1	Homo sapiens	107-112	
9544731-5	1998	NO donor, S-Nitroso-n-acetylpenicillamine (SNAP) or 3-morpholinosydnonimine (SIN-1) (0.1-1.0 mmol/l) dose-dependently reduced copper-induced oxidation of LDL as demonstrated by the inhibition of electrophoretic mobilities on agarose gels and the formation of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes.	linsidomine	52-75	MAPK associated protein 1	Homo sapiens	77-82	
9441836-2	1997	A 6-h pre-incubation with the nitric oxide (NO) donor linsidomine (SIN-1, 10-150 microM) protected endothelial cells in a concentration-dependent manner and increased viability by up to 59% of control.	linsidomine	54-65	MAPK associated protein 1	Homo sapiens	67-72	
9444302-2	1997	The nitric oxide donor 3-morpholino-sydnonimine (SIN-1) (0.1 mmol/L) suppressed the beta-agonist isoproterenol- (1 mumol/L) stimulated increase in ICa-L and decreased the frequency and amplitude of spontaneous action potentials.	linsidomine	23-47	MAPK associated protein 1	Homo sapiens	49-54	
9489619-9	1998	Similarly, 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells was inhibited by NS 2028 (IC50 30 nM).	linsidomine	11-35	MAPK associated protein 1	Homo sapiens	37-42	
9463631-2	1997	METHODS: 3-Morpholinosydnonimine (SIN-1, 0.1 mM), an ONOO- donor, was administered alone or combined with superoxide dismutase (SOD, 300 U/ml) or glutathione (GSH, 1 mM) at the time of reperfusion.	linsidomine	9-32	MAPK associated protein 1	Homo sapiens	34-39	
9390110-4	1997	METHODS: We tested the vascular effects of nitroglycerin and linsidomine (SIN-1) in forearm resistance arteries (venous occlusion plethysmography) and hand veins (venous compliance technique) using a randomized, double-blind placebo-controlled regimen in 33 healthy subjects (age range, 22 to 38 years; mean age, 26 years) before and after 7 days of assignment to either 1 week of nitroglycerin administration (0.83 mg/hr) for induction of tolerance or placebo administration.	linsidomine	61-72	MAPK associated protein 1	Homo sapiens	74-79	
9291107-6	1997	In contrast, 3-[morpholinosydnonimine hydrochloride] (SIN-1), a peroxynitrite-forming compound, did not significantly inhibit either DNA synthesis or the EGFR tyrosine kinase activity.	linsidomine	13-52	MAPK associated protein 1	Homo sapiens	54-59	
9327781-2	1997	In this study, we investigated the effects of the nitric oxide donor 3-morpholino-sydnonimine (SIN-1) on platelet and neutrophil adhesion, and the vasomotor response, in a porcine model of angioplasty.	linsidomine	69-93	MAPK associated protein 1	Homo sapiens	95-100	
9283566-4	1997	Cultures of human osteoblasts were exposed to 0.1, 1.0, and 10 microM of the nitric oxide releasing agent 3-morpholino sydnonimine (SIN-1) for 7 days.	linsidomine	106-130	MAPK associated protein 1	Homo sapiens	132-137	
9288123-6	1997	METHODS: PMNs isolated from human volunteers were preincubated with the NO donor 3-morpholinosydnonimine hydrochloride (SIN-1; 10(-6) to 10(-2) mol/L), cGMP (10(-3) mol/L), or the cell-permeable cGMP analog dibutyryl-cGMP (10(-3) mol/L) for 10 minutes.	linsidomine	81-118	MAPK associated protein 1	Homo sapiens	120-125	
9280288-5	1997	On the other hand, nitric oxide and superoxide generated concomitantly from 3-morpholinosydnonimine (SIN-1) did not induce appreciable hemolysis, while it converted hemoglobin to methemoglobin extensively.	linsidomine	76-99	MAPK associated protein 1	Homo sapiens	101-106	
9441903-2	1997	A 6-h preincubation with linsidomine (SIN-1, 0.5 mM) protected endothelial cells from hydrogen peroxide-dependent cytotoxicity and increased the surviving endothelial cell fraction by 85%.	linsidomine	25-36	MAPK associated protein 1	Homo sapiens	38-43	
9262367-4	1997	The NO-donor drugs molsidomine, 3-morpholinosydnone-imine (SIN-1), sodium nitroprusside (SNP) and glyceryl-trinitrate reduced the pulmonary hypertension in a dose-dependent fashion, whether admixed to the perfusate or inhaled as alveolar-accessible aerosol particles (aerosolization time 3-6 min), with an efficiency ranking of SNP > SIN-1 >> molsidomine and glyceryl-trinitrate.	linsidomine	32-57	MAPK associated protein 1	Homo sapiens	59-64	
9262367-4	1997	The NO-donor drugs molsidomine, 3-morpholinosydnone-imine (SIN-1), sodium nitroprusside (SNP) and glyceryl-trinitrate reduced the pulmonary hypertension in a dose-dependent fashion, whether admixed to the perfusate or inhaled as alveolar-accessible aerosol particles (aerosolization time 3-6 min), with an efficiency ranking of SNP > SIN-1 >> molsidomine and glyceryl-trinitrate.	linsidomine	32-57	MAPK associated protein 1	Homo sapiens	337-342	
9202724-1	1997	We have previously used the comet assay to demonstrate that the nitric oxide donor 3-morpholinosydnonimine (SIN-1) produces DNA damage in rat islets of Langerhans and in the SV40-transformed insulin-secreting hamster cell line, HIT-T15.	linsidomine	83-106	MAPK associated protein 1	Homo sapiens	108-113	
9215025-6	1997	The combined nitric oxide-superoxide donor, 3-morpholinosydnonimine (SIN-1), dose-dependently decreased lipopolysaccharide-mediated IL-8 accumulation (P < 0.01).	linsidomine	44-67	MAPK associated protein 1	Homo sapiens	69-74	
9250372-9	1997	The NO donor 3-morpholinosydnonimine hydrochloride (SIN-1) at 200 microM caused hyperpolarizations (10-15 mV) similar to the IJP mediator, attenuated the IJPs, and abolished mechanical activities.	linsidomine	13-50	MAPK associated protein 1	Homo sapiens	52-57	
9145927-1	1997	This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) on human neutrophil degranulation.	linsidomine	103-127	MAPK associated protein 1	Homo sapiens	129-134	
9175727-1	1997	The nitric oxide (NO) donor SIN-1 (3-morpholinosydnonimine) induced a concentration-dependent inhibition of the secretory response to glucose.	linsidomine	35-58	MAPK associated protein 1	Homo sapiens	28-33	
9144574-1	1997	The cytotoxic effects of 3-morpholinosydnonimine (Sin-1) and S-nitroso-N-acetylpenicillamine-amine (SNAP) on replicatively active human hepatocyte cells in culture was determined as a function of oxidant type.	linsidomine	25-48	MAPK associated protein 1	Homo sapiens	50-55	
9114976-3	1997	Tocored and NGT also were formed when gamma-TH was exposed to 3-morpholinosydnonimine (SIN-1), a compound that decomposes to form peroxynitrite.	linsidomine	62-85	MAPK associated protein 1	Homo sapiens	87-92	
9109387-1	1997	This study investigates whether nitric oxide (NO) release from linsidomine (SIN-1), the active metabolite of the antianginal drug molsidomine, is light sensitive.	linsidomine	63-74	MAPK associated protein 1	Homo sapiens	76-81	
9034630-2	1996	The aim of this study is to establish the ability of the known NO donor 3-morpholinosydnonimine (SIN-1) to prevent the cyclosporin A-induced contraction by using rat isolated glomeruli and cultured glomerular mesangial cells.	linsidomine	72-95	MAPK associated protein 1	Homo sapiens	97-102	
8982501-2	1996	The NO donor 3-morpholino-sydnonimine (SIN-1; 0.01-10 microM) evoked concentration-dependent relaxation of rat isolated mesenteric arteries pre-constricted with phenylephrine (1-3 microM).	linsidomine	13-37	MAPK associated protein 1	Homo sapiens	39-44	
9190765-4	1997	This resulted in clinical studies with the intracavernous injected nitric oxide-donor linsidomine (SIN 1) and the orally given phosphodiesterase-inhibitor sildenafil.	linsidomine	86-97	MAPK associated protein 1	Homo sapiens	99-104	
8951422-5	1996	In contrast, 3-morpholinosydnonimine (SIN-1), a compound that rapidly generates peroxynitrite (ONOO-) from the released NO and O2-, slightly stimulated the PMA-induced respiratory burst.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
8902271-1	1996	Exposure of isolated calf thymus DNA and human skin epidermal keratinocytes to peroxynitrite or the peroxynitrite generator, 3-morpholinosydnonimine (SIN-1), led to extensive DNA base modification.	linsidomine	125-148	MAPK associated protein 1	Homo sapiens	150-155	
8912669-4	1996	As .NO sources we used .NO gas and two .NO-donors, S-nitroso-N-acetyl-D,L-penicillamine and 3-morpholinosydno-nimine hydrochloride (SIN-1).	linsidomine	92-130	MAPK associated protein 1	Homo sapiens	132-137	
9047077-5	1996	This IL-1 beta-mediated induction of ICAM-1 and VCAM-1 expression was significantly inhibited in the presence of a NO donor 3-morpholino-sydnonimine (SIN-1) in a dose-dependent manner.	linsidomine	124-148	MAPK associated protein 1	Homo sapiens	150-155	
8806782-6	1996	SP-A was also nitrated to a large extent following exposure to 3-morpholinosydnonimine (SIN-1) or tetranitromethane at pH 8.	linsidomine	63-86	MAPK associated protein 1	Homo sapiens	88-93	
8764220-5	1996	By contrast, 3-morpholinosydnonimine (SIN-1), which generates ONOO- by releasing O2- and .NO essentially in a simultaneous manner, significantly inhibited signaling.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
8862144-6	1996	On the other hand, the NO donor SIN-1 (3-morpholino-sydnonimine, 10 microM) accelerated the decline in [Ca2+]i and contraction.	linsidomine	39-63	MAPK associated protein 1	Homo sapiens	32-37	
7535933-10	1995	However, bone resorption depends on precursor replication and on the activity of the mature cells, and we found that the NO donor 3-morpholinosydnonimine (SIN-1) (50 microM) profoundly depressed replication in the human preosteoclast line.	linsidomine	130-153	MAPK associated protein 1	Homo sapiens	155-160	
8887971-3	1996	Similarly, unilateral micro-injections (50 nl) of another NO-donor, 3-morpholinosydnonimine (SIN-1, 20-40-100 mM), also induced apnea (5.1 +/- 2.4 sec; 8.7 +/- 4.3 sec; 26.3 +/- 6.4 sec, respectively; n = 6) and a decrease in arterial blood pressure (6.2 +/- 2.3 mmHg; 11.1 +/- 3.3 mmHg; 18.3 +/- 6.1 mmHg, respectively; n = 6).	linsidomine	68-91	MAPK associated protein 1	Homo sapiens	93-98	
8546706-1	1996	We evaluated the effects of two NO donors, sodium nitroprusside (SNP) and 3-morpholino-sydnonimine (SIN-1), characterized by alternative redox states, i.e. nitrosonium ion (NO+) and nitric oxide (NO.)	linsidomine	74-98	MAPK associated protein 1	Homo sapiens	100-105	
9008325-4	1996	Increasing doses of the NO donor linsidomine (SIN-1) were added with and without prior blockade of the NO/cGMP pathway by methylene blue and protein kinase (PK) inhibitors Rp-8-pCPT-cGMPS and RP-8-CPT-cAMPS.	linsidomine	33-44	MAPK associated protein 1	Homo sapiens	46-51	
8719784-15	1995	The NO donor, 3-morpholinosydnonimine (SIN-1) relaxed rat tail arteries precontracted with phenylephrine (1 microM).	linsidomine	14-37	MAPK associated protein 1	Homo sapiens	39-44	
7673115-2	1995	3-Morpholinosydnonimine (SIN-1) is widely used to generate nitric oxide (NO(x).)	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
7639707-3	1995	In the present study, we show that 3-morpholino-sydnonimine (SIN-1) is much more efficient than sodium nitroprusside (SNP) in stimulating the covalent labelling of GAPDH from cultured striatal neurones in the presence of [adenylate-32P]NAD+ (877 +/- 110 and 266 +/- 33% increase in NAD(+)-labelling induced by maximally effective concentrations of SIN-1 and SNP respectively).	linsidomine	35-59	MAPK associated protein 1	Homo sapiens	61-66	
7639707-3	1995	In the present study, we show that 3-morpholino-sydnonimine (SIN-1) is much more efficient than sodium nitroprusside (SNP) in stimulating the covalent labelling of GAPDH from cultured striatal neurones in the presence of [adenylate-32P]NAD+ (877 +/- 110 and 266 +/- 33% increase in NAD(+)-labelling induced by maximally effective concentrations of SIN-1 and SNP respectively).	linsidomine	35-59	MAPK associated protein 1	Homo sapiens	348-353	
7543172-3	1995	The endothelium-dependent relaxation to acetylcholine (ACh 1 nM-10 microM) and substance P (30 nM) was considerably reduced, whereas the relaxing effect to the endothelium-independent nitric oxide donor linsidomine (SIN-1) (100 microM) was unchanged.	linsidomine	203-214	MAPK associated protein 1	Homo sapiens	216-221	
9200208-2	1996	The NO-donor, 3-morpholinosydnonimine (SIN-1), decreased the amplitude of evoked inhibitory postsynaptic currents (buccal ganglion) and potentiated that of evoked excitatory postsynaptic currents (abdominal ganglion).	linsidomine	14-37	MAPK associated protein 1	Homo sapiens	39-44	
8586470-2	1995	Thirty minutes incubation of HWP with 3-morpholino-sydonimine (SIN-1, 10 microM) at 37 degrees C resulted in a 4.6-fold increase of cyclic GMP in platelets, whereas in the extracellular medium the increase was 17.6-fold.	linsidomine	38-61	MAPK associated protein 1	Homo sapiens	63-68	
7582498-6	1995	The relaxation induced by the nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1) was not affected by omega-conotoxin MVIIC.	linsidomine	55-79	MAPK associated protein 1	Homo sapiens	81-86	
7494138-7	1995	In the presence of ISO the CCh-induced inhibition of ICa(L) could be mimicked by the NO donor 3-morpholino-sydnonimine (SIN-1; 0.1 mM).	linsidomine	94-118	MAPK associated protein 1	Homo sapiens	120-125	
7860763-2	1995	Recently, we found that the NO-donor SIN-1 (3-morpholino-sydnonimine) exerts a dual regulation of ICa in frog ventricular myocytes via an accumulation of cGMP.	linsidomine	44-68	MAPK associated protein 1	Homo sapiens	37-42	
7519410-6	1994	After L-NAME, intracarotid infusion of the NO donor 3-morpholinosydnonimine (SIN-1; n = 6) increased resting CBF and reestablished the CBF increase elicited by hypercapnia (P > 0.05 from before L-NAME).	linsidomine	52-75	MAPK associated protein 1	Homo sapiens	77-82	
8682618-3	1995	S-nitroso-N-acetylpenicillamine (SNAP), which generates NO when placed in an aqueous solution, and 3-morpholinosydnonimine (SIN-1), which liberates NO and O2-, resulting in the formation of peroxynitrite, were used as NO donors.	linsidomine	99-122	MAPK associated protein 1	Homo sapiens	124-129	
7925440-7	1994	NO-generating, cGMP-elevating agents [e.g. 3-morpholinosydnonimine hydrochloride (SIN1) and sodium nitroprusside] stimulated VASP Ser157 phosphorylation and inhibited glycoprotein IIb-IIIa activation up to a maximal extent of 30-50%.	linsidomine	43-80	MAPK associated protein 1	Homo sapiens	82-86	
7943250-3	1994	The simultaneous generation of .NO and superoxide by 3-morpholinosydnonimine (SIN-1, 0.1-2 mM) resulted in oxidation of dihydrorhodamine, a marker of peroxynitrite production, and a dose-dependent decrease in the ability of SP-A to enhance lipid aggregation.	linsidomine	53-76	MAPK associated protein 1	Homo sapiens	78-83	
7921622-6	1994	The relaxation to acetylcholine was similar in WKY rats and atenolol-treated SHR and more pronounced than in untreated SHR, whereas the relaxation to the nitric oxide donor 3-morpholinosydnonimine (SIN-1) was comparable in all study groups.	linsidomine	173-196	MAPK associated protein 1	Homo sapiens	198-203	
7717176-1	1995	The study shows that endothelial cells from human umbilical veins have a soluble guanylate cyclase which can be activated by sodium nitroprusside (SNP), SIN-1 (3-morpholinosydnonimine) and S35b (4-methyl-3-phenylsulfonylfuroxan).	linsidomine	160-183	MAPK associated protein 1	Homo sapiens	153-158	
7952568-5	1994	The adenylyl cyclase stimulant forskolin, the nitric oxide donor compound 3-morpholinosydnonimine (SIN-1), and the guanylyl cyclase stimulant sodium nitroprusside caused concentration-dependent relaxation of histamine-contracted airway smooth muscle.	linsidomine	74-97	MAPK associated protein 1	Homo sapiens	99-104	
7531005-1	1994	The effects of intracerebral perfusion of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) and the nitric oxide synthase inhibitor N-nitroarginine (NARG) on the extracellular concentrations of glutamate (GLU) and gamma-aminobutyric acid (GABA) in striatum and CA1 area of the hippocampus were studied.	linsidomine	70-94	MAPK associated protein 1	Homo sapiens	96-101	
8014203-1	1994	We studied whether delayed posttreatment with the nitric oxide donor 3-morpholinosydnonimine (SIN-1) is effective in reducing the size of the infarct produced by occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats (SHRs).	linsidomine	69-92	MAPK associated protein 1	Homo sapiens	94-99	
8208056-1	1994	We observed that N-nitro-L-arginine (NOLA), a nitric oxide biosynthesis inhibitor, exacerbated necrosis in the rabbit heart during ischemia-reperfusion while 3-morpholino-sydnonimine-hydrochloride (SIN-1) (a nitric oxide donor) reduced myocardial damage in the same model.	linsidomine	158-196	MAPK associated protein 1	Homo sapiens	198-203	
7994624-0	1994	[Value of linsidomine (SIN 1) in the evaluation of myocardial viability by 201-Tl scintigraphy after exertion].	linsidomine	10-21	MAPK associated protein 1	Homo sapiens	23-28	
7994624-3	1994	Intravenous injection of linsidomine (SIN 1) a patent coronary vasodilatator, gives more reliable results than conventional imaging at the 4th h, and compares favourably with the results obtained at the 24th h after reinjection of 201 Tl.	linsidomine	25-36	MAPK associated protein 1	Homo sapiens	38-43	
8182511-4	1994	Unlike the nitrovasodilators, nitroglycerin and nicorandil, the nitric oxide donor agents, 3-morpholinosydnonimine (SIN-1) and sodium nitroprusside, both produced enhanced stimulation of LDCL following zymosan at low concentrations of the agonist and inhibition at high concentrations of the agonist.	linsidomine	91-114	MAPK associated protein 1	Homo sapiens	116-121	
7832624-10	1994	Administration of Linsidomine (SIN-1) induced vasodilatation by direct relaxation of the smooth muscle in both groups.	linsidomine	18-29	MAPK associated protein 1	Homo sapiens	31-36	
8294165-0	1993	Pharmacokinetics of linsidomine (SIN 1) after single and multiple intravenous short infusions in patients with renal insufficiency.	linsidomine	20-31	MAPK associated protein 1	Homo sapiens	33-38	
7509893-0	1993	Hemodynamics, tolerability, and pharmacokinetics of linsidomine (SIN-1) infusion during the acute phase of uncomplicated myocardial infarction.	linsidomine	52-63	MAPK associated protein 1	Homo sapiens	65-70	
7509893-5	1993	After baseline hemodynamic values (period A) were determined, linsidomine (SIN-1) was infused at a rate of 0.8 mg/h and subsequently adjusted to obtain a 10% decrease in MBP from its baseline value (period B).	linsidomine	62-73	MAPK associated protein 1	Homo sapiens	75-80	
8294165-1	1993	Pharmacokinetic measurements were performed in two groups of patients with coronary heart disease (CHD) after single and multiple dosing of 2 mg linsidomine (SIN 1).	linsidomine	145-156	MAPK associated protein 1	Homo sapiens	158-163	
8416805-3	1993	Whereas auto-ADP-ribosylation of ADH was stimulated to a minor extent by the NO-liberating agent 3-morpholinosydnonimine (SIN-1), LDH was unaffected.	linsidomine	97-120	MAPK associated protein 1	Homo sapiens	122-127	
7509050-4	1993	The NOl donor SIN-1 (3-morpholinosydnonimine N-ethylcarbamide), at concentrations which produced a much higher guanylate cyclase activation (i.e. NO.	linsidomine	21-61	MAPK associated protein 1	Homo sapiens	14-19	
8274060-1	1993	Linsidomine or SIN-1, a vasodilator of epicardial arteries, is the active metabolite of Molsidomine which is regularly used for intracoronary injection.	linsidomine	0-11	MAPK associated protein 1	Homo sapiens	15-20	
8216333-4	1993	3-Morpholino-sydnonimine (SIN-1) enhanced IL-1 alpha-induced TNF synthesis to a maximum of 272% (mean of n = 5 donors), with 100% set as TNF production by stimulation with IL-1 alpha alone.	linsidomine	0-24	MAPK associated protein 1	Homo sapiens	26-31	
7504139-1	1993	If the vasodilation of the epicardial coronary arteries caused by linsidomine (SIN-1), the active metabolite of molsidomine, is well established, few data are available concerning the effects of SIN-1 on the acetylcholine (ACh)-induced vasoconstriction of epicardial coronary arteries.	linsidomine	66-77	MAPK associated protein 1	Homo sapiens	79-84	
7504146-1	1993	This study compared the action of nitroglycerin (GTN) and linsidomine (SIN-1) on vessel tone and prostacyclin (PGI2) production of human umbilical arteries in vitro.	linsidomine	58-69	MAPK associated protein 1	Homo sapiens	71-76	
1327163-3	1992	or 3-morpholino-sydnonimine-hydrochloride (SIN-1, a compound that spontaneously forms NO .	linsidomine	3-41	MAPK associated protein 1	Homo sapiens	43-48	
1456572-6	1992	The nitric oxide donor compound, 3-morpholinosydnonimine (SIN-1), was equipotent at relaxing the central and peripheral airways.	linsidomine	33-56	MAPK associated protein 1	Homo sapiens	58-63	
1334757-7	1992	The NO donor, 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1; 0.1-30 microM), and the cyclic GMP phosphodiesterase inhibitor, zaprinast (0.1-30 microM) both induced a concentration-dependent inhibition of the electrical field stimulation-induced vasoconstriction, while atrial natriuretic peptide (ANP; 100 nM) produced only a slight decrease of the vasoconstrictor response.	linsidomine	14-54	MAPK associated protein 1	Homo sapiens	56-61	
1512218-1	1992	Nitric oxide and nitric oxide-generating agents like 3-morpholinosydnonimine (SIN-1) stimulate the mono-ADP-ribosylation of a cytosolic, 39-kDa protein in various tissues.	linsidomine	53-76	MAPK associated protein 1	Homo sapiens	78-83	
1324680-1	1992	3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase.	linsidomine	0-24	MAPK associated protein 1	Homo sapiens	26-31	
1777378-3	1991	The elimination half-life of the active metabolite, linsidomine (SIN-1) was also prolonged in cirrhotic patients (7.5 +/- 5.4 h vs 1.0 +/- 0.19 h, P less than 0.05).	linsidomine	52-63	MAPK associated protein 1	Homo sapiens	65-70	
1414692-0	1992	Effect of prostaglandin E2 and 3-morpholinosydnonimine (SIN-1) on arachidonic acid metabolism in fMLP-stimulated rat neutrophils and on thrombin-induced human platelet aggregation.	linsidomine	31-54	MAPK associated protein 1	Homo sapiens	56-61	
1314618-2	1992	3-Morpholino-sydnonimine (SIN-1) blocked both NMDA-induced currents and the associated increase in intracellular Ca2+.	linsidomine	0-24	MAPK associated protein 1	Homo sapiens	26-31	
1322663-2	1992	Sodium nitroprusside (SNP) and SIN-1 (3-morpholinosydnonimine), which spontaneously release the free radical nitric oxide (NO), cause direct relaxation of blood vessels and inhibition of platelet aggregation by activating soluble guanylate cyclase.	linsidomine	38-61	MAPK associated protein 1	Homo sapiens	31-36	
1310595-3	1992	We have used 3-morpholinosydnonimine N-ethylcarbamide (SIN-1), a sydnonimine capable of generating both NO and superoxide simultaneously, to test this hypothesis.	linsidomine	13-53	MAPK associated protein 1	Homo sapiens	55-60	
2175809-10	1990	The peptide antagonists affected only minimally or not at all the production of cyclic GMP evoked by a donor of nitric oxide, SIN-1 (3-Morpholino-Sydnonimine).	linsidomine	133-157	MAPK associated protein 1	Homo sapiens	126-131	
2207507-16	1990	In contrast, the relaxations to the nitric oxide donor, 3-morpholinosydnonimine (SIN-1; the active metabolite of molsidomine), did not differ in the three age groups.	linsidomine	56-79	MAPK associated protein 1	Homo sapiens	81-86	
2156106-1	1990	To find out whether 3-morpholino-sydnonimine (SIN 1), the active metabolite of molsidomine, exerts its antiaggregatory effects not only in vitro but also in vivo, we tested ex vivo aggregation before and after intravenous application of molsidomine in healthy volunteers.	linsidomine	20-44	MAPK associated protein 1	Homo sapiens	46-51	
1697805-2	1990	Molsidomine and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) at 0.01-1 mM, inhibited lysosomal enzyme release from PMN stimulated by 30 nM formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP).	linsidomine	33-56	MAPK associated protein 1	Homo sapiens	58-63	
2565981-5	1989	NG pre-incubation of GC (in contrast to coronary strips) almost completely abolished the direct and thiol-independent stimulatory effect of 3-morpholinosydnonimine (SIN-1) down to 4.5 +/- 0.2%, whereas pre-incubation with other nitrovasodilators reduced the stimulatory response to SIN-1 to only 59 to 98%.	linsidomine	140-163	MAPK associated protein 1	Homo sapiens	165-170	
33806920-1	2021	The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner.	linsidomine	43-66	MAPK associated protein 1	Homo sapiens	68-73	
2542278-7	1989	3-Morpholinosydnonimine (commonly known as SIN-1) (20-1000 micrograms/ml), another compound that acts through the spontaneous formation of nitric oxide as does sodium nitroprusside, also stimulates ADP-ribosylation of the 39-kDa protein.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	43-48	
2484686-1	1989	A previous study revealed that elevation of platelet cyclic GMP induced by a pharmacological activator of soluble guanylate cyclase, 3-morpholinosydnonimine (SIN-1), induced a major inhibition of Ca2+ influx caused by thrombin, as detected by monitoring the fluorescence of the Ca2+ indicator quin-2.	linsidomine	133-156	MAPK associated protein 1	Homo sapiens	158-163	
30425239-1	2018	We show that 3-morpholinosydnonimine (SIN-1)-induced nitric oxide (NO) triggers the formation of SGs.	linsidomine	13-36	MAPK associated protein 1	Homo sapiens	38-43	
29956685-4	2018	For this, spermatozoa were incubated with and without (untreated control) 3-morpholinosydnonimine (SIN-1), in order to generate peroxynitrite.	linsidomine	74-97	MAPK associated protein 1	Homo sapiens	99-104	
30023514-4	2017	3-Morpholinosydnonimine hydrochloride (SIN-1) is an FDA-approved drug for inhibiting platelet aggregation in CVD.	linsidomine	0-37	MAPK associated protein 1	Homo sapiens	39-44	
30116317-3	2018	Therefore, the aim of the present study was to detect altered expression of osteogenesis-related genes in hypertrophic chondrocytes, following treatment with 3-morpholinosydnonimine (SIN-1).	linsidomine	158-181	MAPK associated protein 1	Homo sapiens	183-188	
29746990-8	2018	Lateral ventricular delivery of the NO donor 3-morpholinosydnonimine (SIN-1) reversed inhibitory GnRH and LH responses to FD in high-E rats, and normalized rPO Vglut2, anteroventral periventricular KiSS1, and dorsomedial hypothalamic RFRP-3 mRNA and/or protein profiles.	linsidomine	45-68	MAPK associated protein 1	Homo sapiens	70-75	
30119244-0	2018	3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
30119244-5	2018	Here, we demonstrate that oxidative stress, as induced through treatment with 3-morpholinosydnonimine (SIN-1), a spontaneous ROS/RNS generator, decreased the cell viability in hypertrophic chondrocytes in a dose- and time- dependent manner.	linsidomine	78-101	MAPK associated protein 1	Homo sapiens	103-108	
28086193-6	2017	Levels of carbonylated species increased as early as 15min upon treatment with the peroxynitrite donor, 3-morpholinosydnonimine (SIN-1), and decreased to values close to control after 16h.	linsidomine	104-127	MAPK associated protein 1	Homo sapiens	129-134	
25425609-6	2015	To do this, human spermatozoa from healthy donors were exposed in vitro to 3-morpholinosydnonimine (SIN-1), a molecule that generates peroxynitrite.	linsidomine	75-98	MAPK associated protein 1	Homo sapiens	100-105	
26629950-3	2016	Using 3-morpholino sydnonimine (Sin-1), we created low fluxes of peroxynitrite in our reaction set-up to demonstrate that salicylaldehyde displays unique features in the detection of physiological fluxes of peroxynitrite, yielding detectable nitration but only minor dimerization products.	linsidomine	6-30	MAPK associated protein 1	Homo sapiens	32-37	
26894599-6	2016	The outstanding selectivity of the present CL probe leads us to detect the exogenous release of ONOO(-) from 3-morpholinosydnonimine (SIN-1) in living cells.	linsidomine	109-132	MAPK associated protein 1	Homo sapiens	134-139	
25552582-7	2015	3-Morpholinosydnonimine (SIN-1) (a donor of peroxynitrite) induced nitration of Kir6.1 subunit but not SUR2B.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
27487446-7	2016	For this purpose, spermatozoa from healthy donors were exposed in vitro to 3-morpholinosydnonimine (SIN-1), a compound which generates peroxynitrite.	linsidomine	75-98	MAPK associated protein 1	Homo sapiens	100-105	
26764324-7	2016	Platelet aggregation was induced by ADP in the presence of AGE up to a concentration of 6.25% (vol:vol) alone or in combination with 3-morpholinosydnonimine (Sin-1), a nitric oxide donor.	linsidomine	133-156	MAPK associated protein 1	Homo sapiens	158-163	
24639107-6	2014	Muscle cells were treated with hydrogen peroxide (H2O2) (500 muM) for 30 min or the peroxynitrite donor 3-morpholinosydnonimine (SIN-1) (1 mM) for 90 min to induce oxidative stress.	linsidomine	104-127	MAPK associated protein 1	Homo sapiens	129-134	
25175370-6	2014	Of note, pre-treatment with 3-morpholinosydnonimine hydrochloride (SIN-1), an inducer of HO-1 expression, markedly attenuated cilostazol-induced chondrocyte senescence, and thus, we examined whether HO-1 directly modulates chondrocyte senescence induced by cilostazol.	linsidomine	28-65	MAPK associated protein 1	Homo sapiens	67-72	
25476852-5	2015	We found that incubation of purified recombinant Sirt6 protein with 3-morpholinosydnonimine (SIN-1; a peroxynitrite donor that generates nitric oxide and superoxide simultaneously) increased Sirt6 tyrosine nitration and decreased its intrinsic catalytic activity.	linsidomine	68-91	MAPK associated protein 1	Homo sapiens	93-98	
24375019-2	2014	SIN-1(3-morpholino-sydnonimine), which can lead the simultaneous generation of superoxide anion and nitric oxide, and then form the highly reactive species ONOO(-), induced dose-dependent inhibition in amplitudes of both mEPSCs and sEPSCs.	linsidomine	6-30	MAPK associated protein 1	Homo sapiens	0-5	
23929591-5	2014	The mutant also exhibited an increased susceptibility to the nitric oxide-generating compound S-nitroso-N-acetylpenicillamine (SNAP) and 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor.	linsidomine	137-174	MAPK associated protein 1	Homo sapiens	176-181	
23567270-6	2013	Purified, recombinant PGIS showed a half-maximal nitration by 10 muM 3-morpholino sydnonimine (Sin-1) which increased in the presence of bicarbonate, and was only marginally induced by freely diffusing NO2-radicals generated by a peroxidase/nitrite/hydrogen peroxide system.	linsidomine	69-93	MAPK associated protein 1	Homo sapiens	95-100	
24351819-8	2013	As a conclusion, we believe that using 3-morpholinosydnonimine hydrochloride (Sin-1) as a ROS inducer in the DCF assay is feasible only qualitatively.	linsidomine	39-76	MAPK associated protein 1	Homo sapiens	78-83	
23529546-5	2013	Incubation of phiX-174 plasmid DNA with the peroxynitrite generator 3-morpholinosydnonimine (SIN-1) led to the formation of both single- and double-stranded DNA breaks in a concentration-dependent manner.	linsidomine	68-91	MAPK associated protein 1	Homo sapiens	93-98	
21376033-3	2011	In a cell-free system, MHY336 exhibited a potent activity on scavenging of reactive oxygen species against 3-morpholinosydnonimine hydrochloride (SIN-1)-induced oxidative stress.	linsidomine	107-144	MAPK associated protein 1	Homo sapiens	146-151	
22607494-2	2013	In this study, the effects of DETA-NONOate, a pure NO slow generator, and of SIN-1 (3-morpholinosydnonimine), a peroxynitrite producer, on the activities of respiratory pathways, enzymatic and non-enzymatic antioxidants have been investigated in isolated mitochondria from pea leaves.	linsidomine	84-107	MAPK associated protein 1	Homo sapiens	77-82	
22514319-1	2012	Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO-) donor]; ONOO- can be produced from nitric oxide and reactive oxygen species during neurodegeneration.	linsidomine	75-98	MAPK associated protein 1	Homo sapiens	100-105	
22656049-2	2012	Here, we compared two free-radical generators, 3-morpholinosydnonimine (SIN-1) and 2,2"-azo-bis(2-amidinopropane) hydrochloride (AAPH), by measuring the thiol oxidation kinetics of various thiols.	linsidomine	47-70	MAPK associated protein 1	Homo sapiens	72-77	
22354542-8	2012	A disulfide bond between Cys6 and Cys113 was identified in 3-morpholinosydnonimine hydrochloride (SIN-1)-treated SR monomer and dimer.	linsidomine	59-96	MAPK associated protein 1	Homo sapiens	98-103	
21945407-3	2012	The aim of our work was to study the response of human endothelial cells to 3-morpholinosydnonimine (SIN-1), a peroxynitrite donor, and to highlight the possible protective roles of Nrf2 or the UPR pathway in this response.	linsidomine	76-99	MAPK associated protein 1	Homo sapiens	101-106	
22848780-1	2012	3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies.	linsidomine	0-23	MAPK associated protein 1	Homo sapiens	25-30	
21676000-6	2011	Among the induced proteins, ferredoxin-NADP reductase (FNR) was selected to evaluate the effect of nitration on its activity after heat stress and in vitro conditions using 3-morpholinosydnonimine (SIN-1) (peroxynitrite donor) as the nitrating agent, the FNR activity being inhibited.	linsidomine	173-196	MAPK associated protein 1	Homo sapiens	198-203	
21598373-1	2011	Oxidation of dihydrorhodamine 123 (DHR) to rhodamine 123 (RH) by oxoperoxonitrite (ONOO(-)), formed through recombination of NO and O(2)( -) radicals resulting from thermal decomposition of 3-morpholinosydnonimine (SIN-1) in buffered aerated aqueous solution at pH 7.6, represents a kinetic model system of the reactivity of NO and O(2)( -) in biochemical systems.	linsidomine	190-213	MAPK associated protein 1	Homo sapiens	215-220	
21663688-1	2011	BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA).	linsidomine	66-90	MAPK associated protein 1	Homo sapiens	92-97	
21030671-3	2011	In this study ONOO(-) or 3-morpholinosydnonimine (Sin-1, a ONOO(-) donor) was applied to rat skinned muscle fibers to characterize the effects on contractile properties.	linsidomine	25-48	MAPK associated protein 1	Homo sapiens	50-55	
21297123-8	2011	Molsidomine tended to increase MAP duration by 20.7 +- 13.4 ms. Incubation of isolated atrial myocytes with NO donor 3-morpholino-sydnonimine (SIN-1) increased significantly l-type Ca(2+) current and [Ca(2+)](i) transients.	linsidomine	117-141	MAPK associated protein 1	Homo sapiens	143-148	
21239635-7	2011	In cultured human umbilical vein endothelial cells (HUVECs) exposed to elevated glucose (450 mg/dl) or ONOO derived from 3-morpholinosydnonimine (SIN-1), expression of COX-2 was increased and was prevented when endothelial cells were treated with FeTMPyP.	linsidomine	121-144	MAPK associated protein 1	Homo sapiens	146-151	
20463302-4	2010	Incubation of varphiX-174 plasmid DNA, with 3-morpholinosydnonimine (SIN-1), a peroxynitrite generator, led to the formation of DNA strand breaks in a concentration- and time-dependent manner.	linsidomine	44-67	MAPK associated protein 1	Homo sapiens	69-74	
20187709-3	2010	SIN-1 (3-morpholinosydnonimine) was used to elicit various degrees of nitroxidative stress in a reaction buffer and DAN (2,3-diaminonaphthalene) was used as a probe for N-nitrosation reaction.	linsidomine	7-30	MAPK associated protein 1	Homo sapiens	0-5