PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11483407-4 2001 Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor (D 609) attenuated TNF-alpha-induced ICAM-1 expression. Tyrphostins 41-51 tumor necrosis factor Homo sapiens 142-151 8937718-4 1996 In this study we have investigated the effects of the tyrosine kinase inhibitors, ST638, tyrphostin AG 1288 and genistein, on TNF alpha-induced ICAM-1 expression in human alveolar epithelial (A549) and vascular endothelial (EAhy926) cell lines and also normal human lung microvascular endothelial cells (HLMVEC). Tyrphostins 89-99 tumor necrosis factor Homo sapiens 126-135 11483407-11 2001 NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by TNF-alpha and these effects were inhibited by D 609, calphostin C, or tyrphostin 23, but not by PD 98059 or SB 203580. Tyrphostins 146-156 tumor necrosis factor Homo sapiens 76-85 10734059-6 2000 Tyrphostin, an inhibitor of the EGF receptor intrinsic tryosine kinase, prevented or markedly attenuated the decrease in apoB secretion by TNF-alpha or IL-1beta. Tyrphostins 0-10 tumor necrosis factor Homo sapiens 139-148 9416416-0 1997 Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-alpha antibodies and tyrphostin. Tyrphostins 148-158 tumor necrosis factor Homo sapiens 14-46 7927986-3 1994 In addition, NLD and zymosan induced TNF alpha secretion which was impaired by a PTK inhibitor, tyrphostin. Tyrphostins 96-106 tumor necrosis factor Homo sapiens 37-46 8660850-6 1996 In addition, strong inhibition (81%) of BCG-induced TNF-alpha secretion was observed with tyrphostin (30 microM), another specific protein tyrosine kinase with a different mechanism of action. Tyrphostins 90-100 tumor necrosis factor Homo sapiens 52-61 8537661-3 1996 Of 10 substances tested, only the protein tyrosine kinase inhibitor tyrphostin AG 126 discriminated significantly between PG and LPS: TNF-alpha release induced by PG, but not by LPS, was dose-dependently suppressed. Tyrphostins 68-78 tumor necrosis factor Homo sapiens 134-143 8061118-5 1994 Incubation of tumor cells with genistein or tyrphostin, known TK inhibitors, protected against TNF cytotoxicity in a dose-dependent manner. Tyrphostins 44-54 tumor necrosis factor Homo sapiens 95-98