PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30229539-0	2018	Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells.	Tyrphostins	46-56	insulin like growth factor 1	Homo sapiens	85-113	
7847103-4	1994	Specific tyrosine kinase inhibitors (tyrphostins) blocked the effects of both FSH and IGF-I on aromatase activity without altering FSH-induced cAMP accumulation.	Tyrphostins	37-48	insulin like growth factor 1	Homo sapiens	86-91	
15271882-4	2004	We found that an oral carcinoma cell line overexpressing EGFR, Ca9-22, exhibited IGF-I-induced activation of both Akt and ERK, but that only the latter was significantly decreased by a specific inhibitor of EGFR-TK, tyrphostin AG1478.	Tyrphostins	216-226	insulin like growth factor 1	Homo sapiens	81-86	
15998644-4	2005	We showed that the JAK/STAT pathway is involved in this rescue as tyrphostin AG490, a specific inhibitor of JAK/STAT, completely inhibits cell survival in response to IGF-1.	Tyrphostins	66-76	insulin like growth factor 1	Homo sapiens	167-172	
15976035-7	2005	Inhibition of IGF1R autophosphorylation by the tyrphostin AG1024 (3-bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile) resulted in the inhibition of IGF1-induced BRET signal between the IGF1R and PTP1B.	Tyrphostins	47-57	insulin like growth factor 1	Homo sapiens	14-18	
15291751-5	2004	Signal relay from IGF-I to ERK requires heterotrimeric G proteins and EGFR; inhibition of Gi/o protein activation by pertussis toxin, or EGFR by tyrphostin AG1478 obliterated the ability of IGF-I to promote ERK activation.	Tyrphostins	145-155	insulin like growth factor 1	Homo sapiens	18-23	
12872985-7	2003	The tyrosine kinase inhibitor, tyrphostin, abolished both IL-4- and IL-4 plus IGF-1-mediated induction of STAT6 and the subsequent CD23 expression.	Tyrphostins	31-41	insulin like growth factor 1	Homo sapiens	78-83