PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11093788-8	2000	NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by IL-1beta and these effects were inhibited by tyrphostin 23, but not by PD 98059 or SB 203580.	Tyrphostins	121-131	interleukin 1 beta	Homo sapiens	76-84	
12193665-8	2002	Acute treatment with the protein tyrosine kinase inhibitor, tyrphostin 25, inhibited basal and IL-1 beta-induced COX activities, suggesting the importance of posttranslational modifications in endothelial COX-2 activation in human brain.	Tyrphostins	60-70	interleukin 1 beta	Homo sapiens	95-104	
11076808-5	2000	Neutralizing antibodies to epidermal growth factor (EGF) and transforming growth factor-alpha or inhibition of the EGF receptor by tyrphostin AG-1478 or genistein inhibited IL-1beta-induced alveolar epithelial repair, indicating that IL-1beta enhances in vitro alveolar epithelial repair by an EGF- or transforming growth factor-alpha-dependent mechanism.	Tyrphostins	131-141	interleukin 1 beta	Homo sapiens	173-181	
11093788-2	2000	Tyrosine kinase inhibitors (genistein or tyrphostin 23) or phosphatidylcholine-specific phospholipase C inhibitor (D609) attenuated IL-1beta-induced ICAM-1 expression.	Tyrphostins	41-51	interleukin 1 beta	Homo sapiens	132-140	
8602840-8	1996	The increased COX-2 protein and activity in response to IL-1beta (10 ng/ml) was inhibited by the tyrosine kinase inhibitors tyrphostin (AG126; 0.015 to 15 microM) or erbstatin (0.004 to 4 microM).	Tyrphostins	124-134	interleukin 1 beta	Homo sapiens	56-64	
10617676-3	2000	The tyrosine kinase inhibitors (genistein and tyrphostin AG126) and phosphatidylcholine-phospholipase C inhibitor (D-609) prevented IL-1beta-induced prostaglandin E(2) (PGE(2)) release and COX-2 expression, whereas U-73122 (a phosphatidylinositol-phospholipase C inhibitor) and propranolol (a phosphatidate phosphohydrolase inhibitor) had no effect.	Tyrphostins	46-56	interleukin 1 beta	Homo sapiens	132-140	
10734059-6	2000	Tyrphostin, an inhibitor of the EGF receptor intrinsic tryosine kinase, prevented or markedly attenuated the decrease in apoB secretion by TNF-alpha or IL-1beta.	Tyrphostins	0-10	interleukin 1 beta	Homo sapiens	152-160	
7861699-10	1994	The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity.	Tyrphostins	96-106	interleukin 1 beta	Homo sapiens	165-169