PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8554977-9 1996 We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. Tyrphostins 207-217 DNA damage inducible transcript 3 Homo sapiens 45-52 9586958-7 1998 Elevated expression of gadd45 by medium depletion (starvation) was partially reduced by the addition of either genistein or tyrphostin, two protein tyrosine kinase inhibitors, while gadd153 was affected by tyrphostin only. Tyrphostins 206-216 DNA damage inducible transcript 3 Homo sapiens 182-189