PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17295209-3	2007	EGFR-ERK signaling was manipulated through ligand activation or signal interruption using the tyrphostin AG1478, or MEK inhibitor PD 184352.	Tyrphostins	94-104	mitogen-activated protein kinase 1	Homo sapiens	5-8	
15328380-8	2005	Also, H(2)O(2)-induced ERK activation was attenuated by a receptor tyrosine kinase inhibitor, tyrphostin 51, but not by down-regulation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate or by a PKC inhibitor, GF109203X [3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride].	Tyrphostins	94-104	mitogen-activated protein kinase 1	Homo sapiens	23-26	
12743297-11	2003	Analysis of the JNK, ERK, and p38K mitogen-activated protein kinase pathways revealed that tyrphostin treatment stimulated the activity of JNK and p38K.	Tyrphostins	91-101	mitogen-activated protein kinase 1	Homo sapiens	21-24	
14660604-10	2004	VIP and Bt2cAMP/AM both stimulated ERK MAPK phosphorylation and recruitment of the p85 subunit of phosphatidylinositol 3-kinase (PI3K) to the EGFr in a tyrphostin AG1478-sensitive manner.	Tyrphostins	152-162	mitogen-activated protein kinase 1	Homo sapiens	39-43	
9648731-4	1998	Specific inhibition of EGF-R function by either a dominant-negative EGF-R mutant or selective tyrphostin AG1478 completely abolished Ang II-induced ERK activation.	Tyrphostins	94-104	mitogen-activated protein kinase 1	Homo sapiens	148-151	
12435806-5	2002	HU-210-induced ERK activation was inhibited by tyrphostin AG1478 and PP2, widely employed inhibitors of the epidermal growth factor receptor (EGF(R)) and the Src family of cytosolic tyrosine kinases, respectively.	Tyrphostins	47-57	mitogen-activated protein kinase 1	Homo sapiens	15-18	
11355882-5	2001	In addition, PTX induced phosphorylation of Akt and of ERK2, which could be completely blocked by LY294002 and PD098059, respectively, and by genistein or tyrphostin 47 as well.	Tyrphostins	155-165	mitogen-activated protein kinase 1	Homo sapiens	55-59	
9765228-10	1998	An inhibitor of EGFr phosphorylation, tyrphostin AG1478 (1 microM), reversed CCh-stimulated phosphorylation of both EGFr and ERK.	Tyrphostins	38-48	mitogen-activated protein kinase 1	Homo sapiens	125-128	
11352836-7	2001	Pretreatment with the tyrphostin-derived EGF-R antagonist AG-1478 inhibited mesangial cell proliferation as well as the activation of extracellular signal-regulated kinase 1/2 (ERK1/2 or p42/p44(MAPK)), and p70S6 kinase, a downstream effector of PI3K, providing evidence that MAPK and PI3K activation, respectively, occurred downstream of EGF-R activation.	Tyrphostins	22-32	mitogen-activated protein kinase 1	Homo sapiens	134-175	
27806094-4	2016	Blocking EGFR using Tyrphostin resulted in inhibiting EGFR induced activation of ERK, AKT, and p38.	Tyrphostins	20-30	mitogen-activated protein kinase 1	Homo sapiens	81-84