PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11585905-7	2001	Moreover, we showed that all these TGF-beta1-mediated signaling events, including tubular network formation, were suppressed by incubating TGF-beta1-stimulated endothelial cells with a soluble form of an EGF receptor (ErbB-1) or tyrphostin AG1478, a specific blocker of EGF receptor tyrosine kinase.	Tyrphostins	229-239	epidermal growth factor receptor	Mus musculus	204-216	
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Tyrphostins	5-15	epidermal growth factor receptor	Mus musculus	27-31	
12714603-5	2003	Furthermore, topical application of tyrphostin AG1478 or AG825, specific inhibitors of EGFR and ErbB2, respectively, completely inhibited new hair growth in wild type mice but not in transgenic mice.	Tyrphostins	36-46	epidermal growth factor receptor	Mus musculus	87-91	
15273738-4	2004	Targeting these cells with the specific EGFR inhibitor tyrphostin AG1478 revealed that phosphorylation of ERK was only abrogated in the presence of an intact INK4a/Arf gene locus.	Tyrphostins	55-65	epidermal growth factor receptor	Mus musculus	40-44	
10101228-5	1999	The ARIA-induced increase in AChR subunit expression in C2C12 cells was inhibited by the erbB kinase inhibitor tyrphostin AG1478 and the MEK inhibitor PD98059, but not by the PI3 kinase inhibitor wortmannin, suggesting an important role of the erbB protein tyrosine kinases and MAP kinase in the regulation of the expression of the five different AChR subunits.	Tyrphostins	111-121	epidermal growth factor receptor	Mus musculus	89-93	
8562483-6	1995	When two tyrosine kinase inhibitors (tyrphostins RG50864 and RG13022) were incorporated into the treatment regimens, the TPA-induced epidermal hyperplasia and cell proliferation were effectively blocked, and the TPA-stimulated EGFr tyrosine phosphorylation was significantly reduced.	Tyrphostins	37-48	epidermal growth factor receptor	Mus musculus	227-231	
7585601-6	1995	Disruption of EGF-R mediated signal transduction in NODC-2 cells both by treatment with tyrphostin-25 or by transfection with a vector expressing a dominant negative EGF-R mutant resulted in reacquisition of contact-inhibited growth and suppression of anchorage-independent, clonogenic growth in soft agar.	Tyrphostins	88-98	epidermal growth factor receptor	Mus musculus	14-19	
7752576-4	1995	EGF-R tyrosine kinase inhibition was achieved by incubation with a synthetic tyrphostin (TP B42) (0.1 microM) or genestein (5.5 micrograms/ml).	Tyrphostins	77-87	epidermal growth factor receptor	Mus musculus	0-5	
8076525-7	1993	Tyrphostin RG 50864, which inhibits EGF receptor kinase activity, inhibits EGF stimulation of tyrosine phosphorylation in a concentration-dependent manner and severely retards mandibular development yet increases tooth size.	Tyrphostins	0-10	epidermal growth factor receptor	Mus musculus	36-48	
8527310-8	1995	The relationship between GPI hydrolysis and the activity of the EGFR was studied using the tyrosine kinase inhibitors tyrphostin (RG50864) and genistein.	Tyrphostins	118-128	epidermal growth factor receptor	Mus musculus	64-68	
8266997-7	1993	Tyrphostin RG 50864, which inhibits EGF receptor kinase activity, inhibits EGF or TGF-alpha stimulation of tyrosine phosphorylation in a concentration-dependent manner and severely retards mandibular development [Shum et al., 1993: Development 118:903-917].	Tyrphostins	0-10	epidermal growth factor receptor	Mus musculus	36-48	
32538139-6	2020	In WT mice, treatment with NS-398 (a COX2 inhibitor), clodronate (a macrophage-depleting agent), or tyrphostin (an EGFR inhibitor) resulted in 30% reductions in crypt fission and Lgr5+ stem cell proliferation compared with control mice.	Tyrphostins	100-110	epidermal growth factor receptor	Mus musculus	115-119