PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12193593-4 2002 Tyrphostin AG490, a specific inhibitor of Jak-2, significantly reduced tyrosine phosphorylation and DNA binding activity of STAT-3 and DNA synthesis induced by 5(S)-HETE. Tyrphostins 0-10 signal transducer and activator of transcription 3 Homo sapiens 124-130 28713982-8 2017 Treatment with the JAK2/STAT3 inhibitor tyrphostin AG490, or SOCS3 overexpression, appeared to prevent the HG-induced alterations in protein expression. Tyrphostins 40-50 signal transducer and activator of transcription 3 Homo sapiens 24-29 11368440-0 2001 Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Tyrphostins 50-60 signal transducer and activator of transcription 3 Homo sapiens 13-18 11368440-0 2001 Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Tyrphostins 50-60 signal transducer and activator of transcription 3 Homo sapiens 76-81 10728680-5 2000 Furthermore, the Janus kinase inhibitor, tyrphostin AG490, inhibited the constitutive activation of Stat3 and suppressed the growth of human prostate cancer cells. Tyrphostins 41-51 signal transducer and activator of transcription 3 Homo sapiens 100-105 9192639-0 1997 Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Tyrphostins 85-95 signal transducer and activator of transcription 3 Homo sapiens 57-62 9192639-0 1997 Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Tyrphostins 85-95 signal transducer and activator of transcription 3 Homo sapiens 111-116 9192639-7 1997 The Jak kinase inhibitor, tyrphostin AG490, blocked the constitutive activation of Stat3(sm) and inhibited spontaneous as well as interleukin 2-induced growth of MF tumor cells. Tyrphostins 26-36 signal transducer and activator of transcription 3 Homo sapiens 83-88 31846485-10 2019 Pharmacological blockade of JAK2/STAT3 by Tyrphostin AG490 reduced inflammation, tubular apoptosis, and interstitial fibrosis. Tyrphostins 42-52 signal transducer and activator of transcription 3 Homo sapiens 33-38 10508495-6 1999 Inhibition of ErbB-2 kinase activity by tyrphostin AG825 prevented the constitutive activation of STAT 3 in the TGF-alpha-producing, ErbB-1 expressing cell line. Tyrphostins 40-50 signal transducer and activator of transcription 3 Homo sapiens 98-104 19564891-3 2009 In parallel, the treatment with TRAIL and Tyrphostin (AG-490), a selective Janus kinase 2 inhibitor, produces an evident enhancement of cytotoxicity, characterized by a significant inhibition of Stat3 phosphorylation compared to controls or to TRAIL alone-treated samples, and associated with a dramatic decrease of both cIAP-1 and cIAP-2 mRNA levels. Tyrphostins 42-52 signal transducer and activator of transcription 3 Homo sapiens 195-200 19967068-5 2008 Thus, it seems that tyrphostins, which are known as specific inhibitors of the ErbB2 kinase, may have non-specific suppressive effects on the IL-6/STAT3 pathway. Tyrphostins 20-31 signal transducer and activator of transcription 3 Homo sapiens 147-152 19010822-7 2008 Inhibition of Stat3 activation in MIA-MSLN cells by the Janus-activated kinase-selective inhibitor tyrphostin AG490 was followed by a marked decrease in proliferation of the cells. Tyrphostins 99-109 signal transducer and activator of transcription 3 Homo sapiens 14-19 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. Tyrphostins 45-55 signal transducer and activator of transcription 3 Homo sapiens 181-186 18855573-5 2008 The JAK-2 specific inhibitor, Tyrphostin AG490 is used to inhibit phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Tyrphostins 30-40 signal transducer and activator of transcription 3 Homo sapiens 94-144 18855573-5 2008 The JAK-2 specific inhibitor, Tyrphostin AG490 is used to inhibit phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Tyrphostins 30-40 signal transducer and activator of transcription 3 Homo sapiens 146-152 15912144-8 2005 Coincubation of tyrphostins with staurosporine was accompanied by rapid complete inhibition of STAT3 phosphorylation. Tyrphostins 16-27 signal transducer and activator of transcription 3 Homo sapiens 95-100 16517747-6 2006 Finally, a JAK-specific inhibitor, tyrphostin AG490, markedly prevented PAP I-induced NF-kappaB inhibition, pointing to a cross-talk between JAK/STAT3 and NF-kappaB signaling pathways. Tyrphostins 35-45 signal transducer and activator of transcription 3 Homo sapiens 145-150 15912144-10 2005 In conclusion, these findings support the concept that STAT3 signaling is important in the pathogenesis of cHL and tyrphostins are agents for developing new therapeutic strategies. Tyrphostins 115-126 signal transducer and activator of transcription 3 Homo sapiens 55-60 16706231-5 2005 In contrast, tyrphostin AG1478 abrogates tyrosine phosphorylation of PLCgamma1 and STAT3. Tyrphostins 13-23 signal transducer and activator of transcription 3 Homo sapiens 83-88 14580692-4 2003 A JAK-specific inhibitor, tyrphostin AG490, markedly inhibited Stat3 activation and expression of cyclin D1, bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR, as followed by growth arrest (6.3-21.3% vs controls; P<0.001) of pancreatic cancer cells. Tyrphostins 26-36 signal transducer and activator of transcription 3 Homo sapiens 63-68 12949733-11 2003 Blocking of the STAT3 upstream activator Janus kinase 2 by tyrphostin also resulted in growth arrest because of delayed G(1)/S-phase progression and increased expression of p21(WAF1). Tyrphostins 59-69 signal transducer and activator of transcription 3 Homo sapiens 16-21