PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29179737-0	2017	Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification.	Daptomycin	25-35	coagulation factor II, thrombin	Homo sapiens	70-81	
34643345-2	2021	We report on a premature infant who developed hepatotoxicity as an adverse drug reaction after the administration of daptomycin 6 mg per kg per dose every 12 h. The patient had an unexpectedly sharp rise of alanine aminotransaminase, prothrombin time and international normalised ratio on the second day following daptomycin administration.	Daptomycin	117-127	coagulation factor II, thrombin	Homo sapiens	234-245	
34643345-2	2021	We report on a premature infant who developed hepatotoxicity as an adverse drug reaction after the administration of daptomycin 6 mg per kg per dose every 12 h. The patient had an unexpectedly sharp rise of alanine aminotransaminase, prothrombin time and international normalised ratio on the second day following daptomycin administration.	Daptomycin	314-324	coagulation factor II, thrombin	Homo sapiens	234-245	
18180613-0	2008	Interaction of daptomycin with two recombinant thromboplastin reagents leads to falsely prolonged patient prothrombin time/International Normalized Ratio results.	Daptomycin	15-25	coagulation factor II, thrombin	Homo sapiens	106-117	
18180613-3	2008	The present study evaluated the effect of daptomycin on measured prothrombin time using commercially available thromboplastin reagent kits commonly used in the United States.	Daptomycin	42-52	coagulation factor II, thrombin	Homo sapiens	65-76	
18180613-7	2008	Triplicate assays of the prothrombin time were performed on the daptomycin-spiked plasma samples using each of the 30 kits.	Daptomycin	64-74	coagulation factor II, thrombin	Homo sapiens	25-36	
18180613-10	2008	Addition of daptomycin to human plasma samples dose-dependently prolonged measured prothrombin times when two recombinant thromboplastin reagents were utilized.	Daptomycin	12-22	coagulation factor II, thrombin	Homo sapiens	83-94	
18180613-14	2008	Prolonged International Normalized Ratio patient values were an artifact caused by the interaction of daptomycin with the in-vitro prothrombin time test reagent; an in-vivo anticoagulant effect was not observed.	Daptomycin	102-112	coagulation factor II, thrombin	Homo sapiens	131-142	
18180613-15	2008	Healthcare providers should consider a possible drug-laboratory test interaction if prolonged prothrombin time or elevated International Normalized Ratio values are observed in patients receiving daptomycin.	Daptomycin	196-206	coagulation factor II, thrombin	Homo sapiens	94-105	
29179737-1	2017	BACKGROUND: Several studies have reported that daptomycin induced artificial prolongation of prothrombin time (PT) in some test reagents, particularly in warfarin users.	Daptomycin	47-57	coagulation factor II, thrombin	Homo sapiens	93-104	
27060578-0	2016	False Prolongation of Prothrombin Time in the Presence of a High Blood Concentration of Daptomycin.	Daptomycin	88-98	coagulation factor II, thrombin	Homo sapiens	22-33	
28399872-0	2017	Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study.	Daptomycin	82-92	coagulation factor II, thrombin	Homo sapiens	42-53	
28399872-1	2017	BACKGROUND: Daptomycin has been reported to cause artificial prolongation of prothrombin time (PT) by interacting with some test reagents of PT.	Daptomycin	12-22	coagulation factor II, thrombin	Homo sapiens	77-88	
27060578-1	2016	Prothrombin time (PT) can reportedly be falsely prolonged by the antimicrobial drug daptomycin (DAP), and concomitant use of phosphatidylglycerol (PG).	Daptomycin	84-94	coagulation factor II, thrombin	Homo sapiens	0-11	
27060578-1	2016	Prothrombin time (PT) can reportedly be falsely prolonged by the antimicrobial drug daptomycin (DAP), and concomitant use of phosphatidylglycerol (PG).	Daptomycin	96-99	coagulation factor II, thrombin	Homo sapiens	0-11