PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11389878-8 2001 Agents shown to reduce efflux of calcein from resistant cells, i.e. indomethacin, MK-571, and probenecid, also inhibited [(3)H]DNP-SG uptakes, consistent with MRP1 being responsible for export of calcein. fluorexon 33-40 ATP binding cassette subfamily C member 1 Homo sapiens 159-163 22445357-9 2012 We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571. fluorexon 90-97 ATP binding cassette subfamily C member 1 Homo sapiens 36-40 22445357-9 2012 We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571. fluorexon 110-117 ATP binding cassette subfamily C member 1 Homo sapiens 36-40 16960658-15 2007 Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells. fluorexon 59-66 ATP binding cassette subfamily C member 1 Homo sapiens 15-19 16960658-15 2007 Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells. fluorexon 59-66 ATP binding cassette subfamily C member 1 Homo sapiens 156-160 11504821-5 2001 Total calcein efflux was significantly decreased with the MRP1 inhibitors probenecid and indomethacin, while total efflux was unchanged following treatment with CsA. fluorexon 6-13 ATP binding cassette subfamily C member 1 Homo sapiens 58-62 16004972-5 2005 They also inhibited transport in membrane vesicles prepared from tumour cells expressing MRP1 or MRP4 and blocked calcein efflux from MRP1-overexpressing cells and BCECF efflux from MRP4-overexpressing cells. fluorexon 114-121 ATP binding cassette subfamily C member 1 Homo sapiens 89-93 16004972-5 2005 They also inhibited transport in membrane vesicles prepared from tumour cells expressing MRP1 or MRP4 and blocked calcein efflux from MRP1-overexpressing cells and BCECF efflux from MRP4-overexpressing cells. fluorexon 114-121 ATP binding cassette subfamily C member 1 Homo sapiens 134-138 15198509-3 2004 As preclinical drug disposition and pharmacokinetics studies are often conducted in rats, we have recently cloned the rat MRP1 (rMRP1) and demonstrated that rMRP1 expressed in transfected cells effluxes calcein, a commonly used fluorescence substrate for human MRP1. fluorexon 203-210 ATP binding cassette subfamily C member 1 Homo sapiens 129-133 12879156-1 2003 We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL). fluorexon 276-283 ATP binding cassette subfamily C member 1 Homo sapiens 77-81 12879156-1 2003 We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL). fluorexon 276-283 ATP binding cassette subfamily C member 1 Homo sapiens 83-124 11737211-5 2001 In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells. fluorexon 235-242 ATP binding cassette subfamily C member 1 Homo sapiens 25-29 11737211-5 2001 In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells. fluorexon 235-242 ATP binding cassette subfamily C member 1 Homo sapiens 55-59 11737211-5 2001 In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells. fluorexon 235-242 ATP binding cassette subfamily C member 1 Homo sapiens 55-59 11737211-5 2001 In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells. fluorexon 235-242 ATP binding cassette subfamily C member 1 Homo sapiens 55-59 10729360-11 2000 PAK-104P also non-competitively inhibits the MRP(1)-mediated efflux of daunorubicin, pirarubicin, hydroxyrubicin, calcein acetoxymethyl ester and calcein. fluorexon 114-121 ATP binding cassette subfamily C member 1 Homo sapiens 45-50 10764626-3 2000 Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP. fluorexon 37-44 ATP binding cassette subfamily C member 1 Homo sapiens 71-99 10764626-3 2000 Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP. fluorexon 37-44 ATP binding cassette subfamily C member 1 Homo sapiens 101-104 10729360-13 2000 These data strongly suggested the existence of two different mechanisms for the inhibition by PAK-104P of the MRP(1)-mediated efflux of molecules: a first mechanism, involving a low-affinity site for PAK-104P, and which would concern molecules such as calcein, cysteinyl leukotriene LCT(4) etc. fluorexon 252-259 ATP binding cassette subfamily C member 1 Homo sapiens 110-115 9804615-9 1998 Using a fluorescence activated cell sorter assay to measure competition of calcein efflux from MRP-overexpressing cells, 10 compounds were found to increase calcein retention by >/=2-fold. fluorexon 75-82 ATP binding cassette subfamily C member 1 Homo sapiens 95-98 10404077-9 1999 Probenecid, an inhibitor of the MRP pump, significantly increased the accumulation of calcein in PBMC from 3 chronic ATL patients. fluorexon 86-93 ATP binding cassette subfamily C member 1 Homo sapiens 32-35 10025956-4 1999 Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays. fluorexon 236-243 ATP binding cassette subfamily C member 1 Homo sapiens 121-125 9804615-9 1998 Using a fluorescence activated cell sorter assay to measure competition of calcein efflux from MRP-overexpressing cells, 10 compounds were found to increase calcein retention by >/=2-fold. fluorexon 157-164 ATP binding cassette subfamily C member 1 Homo sapiens 95-98 9713496-4 1998 In the present work single-cell fluorescence digital imaging has been applied to characterize the kinetics and inhibitor-sensitivity of calcein accumulation in a mixture of HL60 MRP1 and NIH 3T3 MDR1 cells. fluorexon 136-143 ATP binding cassette subfamily C member 1 Homo sapiens 178-182 33910062-7 2021 DIM has increased the intracellular accumulation of Hoechst and Calcein, the substrates of P-gp and MRP1, respectively, in breast cancer cells. fluorexon 64-71 ATP binding cassette subfamily C member 1 Homo sapiens 100-104 9485370-3 1998 To obtain more insight in the handling of drugs by both proteins, we performed a detailed kinetic analysis of the efflux of calcein-acetoxymethyl ester (CAL-AM), a common neutral substrate for both proteins and compared it with the kinetics of efflux of calcein (CAL) which is only effluxed by MRP. fluorexon 124-131 ATP binding cassette subfamily C member 1 Homo sapiens 294-297 7628644-0 1995 ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. fluorexon 24-31 ATP binding cassette subfamily C member 1 Homo sapiens 39-67 7628644-0 1995 ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion. fluorexon 24-31 ATP binding cassette subfamily C member 1 Homo sapiens 69-72 7628644-2 1995 The transport of calcein by MRP is ATP-dependent and is inhibited by probenecid and vincristine. fluorexon 17-24 ATP binding cassette subfamily C member 1 Homo sapiens 28-31 7628644-4 1995 In conclusion, ATP-dependent transport of calcein and possibly other organic anions by MRP is not inhibited by a large decrease of the intracellular GSH concentration, that inhibits daunorubicin efflux by MRP. fluorexon 42-49 ATP binding cassette subfamily C member 1 Homo sapiens 87-90 30232176-4 2018 Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. fluorexon 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 83-87 31401398-4 2019 Using calcein as a fluorescent reporter in a high content uptake assay, we recently reported the identification of 12 MRP1 inhibitors after screening an anti-cancer library of 386 compounds. fluorexon 6-13 ATP binding cassette subfamily C member 1 Homo sapiens 118-122 33349973-8 2021 The ABCB1 inhibitor zosuquidar, the ABCG2 inhibitor Ko143, and the ABCC1 inhibitor MK571 increased calcein retention. fluorexon 99-106 ATP binding cassette subfamily C member 1 Homo sapiens 67-72 30232176-4 2018 Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. fluorexon 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 131-135 30232176-4 2018 Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells. fluorexon 113-120 ATP binding cassette subfamily C member 1 Homo sapiens 131-135 28258008-9 2017 Inhibition of MRP1 activity was further validated using flow cytometry and confocal microscopy for the respective detection of calcein and doxorubicin in MRP1-overexpressing cells. fluorexon 127-134 ATP binding cassette subfamily C member 1 Homo sapiens 14-18 28258008-9 2017 Inhibition of MRP1 activity was further validated using flow cytometry and confocal microscopy for the respective detection of calcein and doxorubicin in MRP1-overexpressing cells. fluorexon 127-134 ATP binding cassette subfamily C member 1 Homo sapiens 154-158