PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19555719-7 2009 It is based on evidence that chronic administration of lithium, carbamazepine, sodium valproate, or lamotrigine to rats downregulated AA turnover in brain phospholipids, formation of prostaglandin E(2), and/or expression of AA cascade enzymes, including cytosolic phospholipase A(2), cyclooxygenase-2 and/or acyl-CoA synthetase. Lamotrigine 100-111 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 284-300 20021459-4 2009 In the rat brain, some of the mood stabilizers effective in treating mania (lithium, carbamazepine, valproate) or depression (lamotrigine) in BD are reported to decrease transcription of cytosolic phospholipase A(2) and cyclooxygenase-2 and to reduce levels of AP-2 and NF-kappaB, transcription factors of the two enzymes. Lamotrigine 126-137 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 220-236