PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25854934-2 2015 Chronic LTG treatment rescues the suppressed long-term potentiation, loss of spines and cognitive deficits in AbetaPP/PS1 mice, known to overexpress a chimeric mouse/human mutant amyloid-beta protein precursor (AbetaPP) and a mutant human presenilin 1 (PS1). Lamotrigine 8-11 amyloid beta precursor protein Homo sapiens 179-191 25854934-2 2015 Chronic LTG treatment rescues the suppressed long-term potentiation, loss of spines and cognitive deficits in AbetaPP/PS1 mice, known to overexpress a chimeric mouse/human mutant amyloid-beta protein precursor (AbetaPP) and a mutant human presenilin 1 (PS1). Lamotrigine 8-11 amyloid beta precursor protein Homo sapiens 211-218 25854934-4 2015 These results suggest LTG treatment reduces Abeta production, possibly through modulation of cleavage of AbetaPP by beta-secretase. Lamotrigine 22-25 amyloid beta precursor protein Homo sapiens 44-49 25854934-4 2015 These results suggest LTG treatment reduces Abeta production, possibly through modulation of cleavage of AbetaPP by beta-secretase. Lamotrigine 22-25 amyloid beta precursor protein Homo sapiens 105-112