PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21097842-5 2011 We find that oxidative inactivation of the lipid phosphatase PTEN by As(2)O(3) enhances cardiac calcium currents in the therapeutic concentration range via a PI3Kalpha-dependent increase in phosphatidylinositol 3,4,5-triphosphate (PIP(3)) production. pip(3) 231-237 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus 61-65 21097842-6 2011 In guinea pig ventricular myocytes, even a modest reduction in PTEN activity is sufficient to increase cellular PIP(3) levels. pip(3) 112-118 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus 63-67 21097842-7 2011 Under control conditions, PIP(3) levels are kept low by PTEN and do not affect calcium current amplitudes. pip(3) 26-32 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Cavia porcellus 56-60