PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14560023-7 2003 This phosphorylation inhibited phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) binding to PKB, thereby preventing activation of the kinase by insulin. pip(3) 73-79 protein tyrosine kinase 2 beta Homo sapiens 92-95 14560023-8 2003 In contrast, a PKB-PH domain with a T34A mutation retained the ability to bind PIP(3) even in the presence of a ceramide-activated PKCzeta and, as such, expression of PKB T34A mutant in L6 cells was resistant to inhibition by ceramide treatment. pip(3) 79-85 protein tyrosine kinase 2 beta Homo sapiens 15-18 14560023-8 2003 In contrast, a PKB-PH domain with a T34A mutation retained the ability to bind PIP(3) even in the presence of a ceramide-activated PKCzeta and, as such, expression of PKB T34A mutant in L6 cells was resistant to inhibition by ceramide treatment. pip(3) 79-85 protein tyrosine kinase 2 beta Homo sapiens 167-170