PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11141077-9 2001 Our findings suggest that insulin, via PIP(3), provokes increases in PKC-zeta enzyme activity through (a) PDK-1-dependent T410 loop phosphorylation, (b) T560 autophosphorylation, and (c) phosphorylation-independent/conformational-dependent relief of pseudosubstrate autoinhibition. pip(3) 39-45 3-phosphoinositide dependent protein kinase 1 Homo sapiens 106-111