PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11897055-3 2002 Mutations in the Btk PH domain result in changes in its affinity for PIP(3), with higher binding leading to cell transformation in vitro and lower binding leading to antibody deficiencies in both humans and mice. pip(3) 69-75 Bruton tyrosine kinase Homo sapiens 17-20