PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24506253-4	2014	Novel small-molecule inhibitors of PKCdelta were designed as chimeric hybrids of two naturally occurring PKCdelta inhibitors, staurosporine and rottlerin.	Staurosporine	126-139	protein kinase C delta	Homo sapiens	35-43	
15334656-6	2004	An unspecific protein kinase C (PKC) inhibitor, staurosporine, disrupted the inhibitory action of leptin.	Staurosporine	48-61	protein kinase C delta	Homo sapiens	32-35	
20299424-5	2010	BK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC).	Staurosporine	100-113	protein kinase C delta	Homo sapiens	157-160	
18313772-3	2008	Accordingly, PKC inhibitors (staurosporine, Go-6976, Go-6983, Ro-318220, BIS-1, chelerythrine, rottlerin, quercetin) enhanced NT receptor binding and NT-induced inositol phosphate (IP) formation.	Staurosporine	29-42	protein kinase C delta	Homo sapiens	13-16	
18048804-6	2008	Acrolein-mediated HO-1 induction was significantly attenuated by pan-protein kinase C (PKC) inhibitors RO318220, staurosporine, and PKC-delta selective inhibitor rottlerin and PKC-delta small interfering RNA.	Staurosporine	113-126	protein kinase C delta	Homo sapiens	87-90	
16455194-6	2006	Treatment of cells with SB202190 (a specific inhibitor of p38), staurosporine (a wide-spectrum inhibitor of PKC) or rottlerin (a specific inhibitor of PKCdelta) all augmented ARE activation by tBHQ.	Staurosporine	64-77	protein kinase C delta	Homo sapiens	108-111	
16715208-1	2006	Staurosporin, a specific inhibitor of PKC, is widely used in studies of signal transduction pathways.	Staurosporine	0-12	protein kinase C delta	Homo sapiens	38-41	
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	Staurosporine	137-150	protein kinase C delta	Homo sapiens	105-108	
11779197-3	2002	Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it.	Staurosporine	157-170	protein kinase C delta	Homo sapiens	38-41	
7539427-5	1995	The increase in tyrosine phosphorylation of PKC delta was blocked by tyrosine kinase inhibitors genistein and staurosporine.	Staurosporine	110-123	protein kinase C delta	Homo sapiens	44-53	
27783407-8	2016	The use of PKCdelta inhibitor candidates, including Go6983, bisindolylmaleimide II, staurosporine, and rottlerin in the assay resulted in IC50 values of 50 nM, 15 nM, 795 nM, and 4 muM, respectively.	Staurosporine	84-97	protein kinase C delta	Homo sapiens	11-19	
8365480-1	1993	The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes delta and epsilon.	Staurosporine	53-66	protein kinase C delta	Homo sapiens	151-154	
8365480-1	1993	The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes delta and epsilon.	Staurosporine	72-85	protein kinase C delta	Homo sapiens	151-154	
8365480-2	1993	H7 and staurosporine, usually used as selective inhibitors of PKC, showed similar inhibitory effects on cPKC (a mixture of cPKC alpha, beta, and gamma) and nPKC delta and epsilon.	Staurosporine	7-20	protein kinase C delta	Homo sapiens	62-65	
8365480-2	1993	H7 and staurosporine, usually used as selective inhibitors of PKC, showed similar inhibitory effects on cPKC (a mixture of cPKC alpha, beta, and gamma) and nPKC delta and epsilon.	Staurosporine	7-20	protein kinase C delta	Homo sapiens	123-166